RPS22B

Summary

Gene Symbol: RPS22B
Description: ribosomal 40S subunit protein S22B
Alias: ribosomal 40S subunit protein S22B
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Otaka E, Higo K, Osawa S. Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast. Biochemistry. 1982;21:4545-50 pubmed
    ..T., Möller, W., Amons, R., & Yaguchi, M. (1980) in Ribosomes: Structure, Function and Genetics (Chambliss, G., et al., Eds.) pp 297-332, University Park Press, Baltimore, MD; M. Yaguchi, unpublished experiments]. ..
  2. Visweswaraiah J, Lageix S, Castilho B, Izotova L, Kinzy T, Hinnebusch A, et al. Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem. 2011;286:36568-79 pubmed publisher
    ..These findings implicate eEF1A in the intricate regulation of Gcn2 and amino acid homeostasis. ..
  3. Waller T, Lee S, Sattlegger E. Evidence that Yih1 resides in a complex with ribosomes. FEBS J. 2012;279:1761-76 pubmed publisher
    ..Close physical proximity of Yih1 to the Gcn1-Gcn2-ribosome complex would allow cells to quickly inhibit Gcn2 whenever or wherever necessary. ..
  4. Kouba T, Dányi I, Gunišová S, Munzarová V, Vlčková V, Cuchalová L, et al. Small ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunit. PLoS ONE. 2012;7:e40464 pubmed publisher
    ..Together we conclude that the interaction between the flexible RPS0A-CTT and the residues 200-400 of the a/TIF32-NTD significantly stimulates attachment of eIF3 and its associated eIFs to small ribosomal subunits in vivo. ..
  5. Visweswaraiah J, Lee S, Hinnebusch A, Sattlegger E. Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation. J Biol Chem. 2012;287:37757-68 pubmed publisher
    ..Together, this suggests that eEF3 blocks Gcn1 regulatory function on the ribosome. We propose that the Gcn1-Gcn2 complex only functions on ribosomes with A-site-bound uncharged tRNA, because eEF3 does not occupy these stalled complexes. ..