Gene Symbol: RPS14A
Description: ribosomal 40S subunit protein S14A
Alias: CRY1, RPL59, ribosomal 40S subunit protein S14A
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Moritz M, Paulovich A, Tsay Y, Woolford J. Depletion of yeast ribosomal proteins L16 or rp59 disrupts ribosome assembly. J Cell Biol. 1990;111:2261-74 pubmed
    ..The implications of these findings for control of ribosome assembly and the order of assembly of ribosomal proteins into the ribosome are discussed. ..
  2. Jakovljevic J, de Mayolo P, Miles T, Nguyen T, Leger Silvestre I, Gas N, et al. The carboxy-terminal extension of yeast ribosomal protein S14 is necessary for maturation of 43S preribosomes. Mol Cell. 2004;14:331-42 pubmed
  3. Granneman S, Nandineni M, Baserga S. The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14. Mol Cell Biol. 2005;25:10352-64 pubmed
    ..We propose that Fap7 mediates cleavage of the 20S pre-rRNA at site D by directly interacting with Rps14 and speculate that it is an enzyme that functions as an NTP-dependent molecular switch in 18S rRNA maturation. ..
  4. Sasaki T, Toh e A, Kikuchi Y. Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus. Mol Cell Biol. 2000;20:7971-9 pubmed
    ..One suppressor is RPS14A, encoding a 40S ribosomal protein...
  5. Polevoda B, Brown S, Cardillo T, Rigby S, Sherman F. Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes. J Cell Biochem. 2008;103:492-508 pubmed
    ..Moreover, Ard1p copurifies with Rpl35p-TAP. We suggest that these two ribosomal proteins, which are in close proximity to the ribosomal exit tunnel, may play a role in NatA attachment to the ribosome. ..
  6. Peña C, Schütz S, Fischer U, Chang Y, Panse V. Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation. elife. 2016;5: pubmed publisher
    ..Thus, prefabrication of a native-like r-protein subcomplex drives efficient and accurate construction of the eukaryotic ribosome. ..
  7. Fewell S, Woolford J. Ribosomal protein S14 of Saccharomyces cerevisiae regulates its expression by binding to RPS14B pre-mRNA and to 18S rRNA. Mol Cell Biol. 1999;19:826-34 pubmed
  8. Planta R, Mager W. The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast. 1998;14:471-7 pubmed
    ..The yeast genome appears to carry 78 different genes, of which 59 are duplicated, encoding 32 different small-subunit and 46 large-subunit proteins. A new nomenclature for these ribosomal proteins is proposed. ..
  9. Carr Schmid A, Pfund C, Craig E, Kinzy T. Novel G-protein complex whose requirement is linked to the translational status of the cell. Mol Cell Biol. 2002;22:2564-74 pubmed
    ..Thus, Hbs1p and Dom34p may function together to help directly or indirectly facilitate the expression either of specific mRNAs or under certain cellular conditions. ..

More Information


  1. Campbell M, Karbstein K. Protein-protein interactions within late pre-40S ribosomes. PLoS ONE. 2011;6:e16194 pubmed publisher
    ..These data suggest that Rio2 could play a central role in regulating cytoplasmic maturation steps. ..
  2. Loc h J, Blaud M, Réty S, Lebaron S, Deschamps P, Bareille J, et al. RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis. PLoS Biol. 2014;12:e1001860 pubmed publisher
    ..Incorporation of Rps14 by Fap7 leads to a structural rearrangement of the platform domain necessary for the pre-rRNA to acquire a cleavage competent conformation. ..
  3. Paulovich A, Thompson J, Larkin J, Li Z, Woolford J. Molecular genetics of cryptopleurine resistance in Saccharomyces cerevisiae: expression of a ribosomal protein gene family. Genetics. 1993;135:719-30 pubmed
    The Saccharomyces cerevisiae CRY1 gene encodes the 40S ribosomal subunit protein rp59 and confers sensitivity to the protein synthesis inhibitor cryptopleurine...
  4. Lauffer S, Mäbert K, Czupalla C, Pursche T, Hoflack B, Rödel G, et al. Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p. J Biol Chem. 2012;287:17447-58 pubmed publisher
    ..We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites. ..