Gene Symbol: RPP1
Description: RNA-binding RNA processing protein RPP1
Alias: RNA-binding RNA processing protein RPP1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Dlakic M. 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p. RNA. 2005;11:123-7 pubmed
    ..This RNA-binding fold is also present in human RNase P subunit Rpp38, raising the possibility that Pop3p and Rpp38 are functional homologs. ..
  2. Lu Q, Wierzbicki S, Krasilnikov A, Schmitt M. Comparison of mitochondrial and nucleolar RNase MRP reveals identical RNA components with distinct enzymatic activities and protein components. RNA. 2010;16:529-37 pubmed publisher
  3. Salinas K, Wierzbicki S, Zhou L, Schmitt M. Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component. J Biol Chem. 2005;280:11352-60 pubmed
    ..Based on this evidence, we propose that YLR145w encodes a novel protein component of RNase MRP, but not RNase P. We recommend that this gene be designated RMP1, for RNase MRP protein 1. ..
  4. Chamberlain J, Lee Y, Lane W, Engelke D. Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev. 1998;12:1678-90 pubmed
    ..The degree of structural similarity between nuclear RNase P and RNase MRP suggests that some aspects of their functions in pre-tRNA and pre-rRNA processing pathways might overlap or be coordinated. ..
  5. Gill T, Cai T, Aulds J, Wierzbicki S, Schmitt M. RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol. 2004;24:945-53 pubmed
    ..In addition, these results denote a new mechanism of mRNA degradation not seen before in the yeast Saccharomyces cerevisiae. ..
  6. Perederina A, Khanova E, Quan C, Berezin I, Esakova O, Krasilnikov A. Interactions of a Pop5/Rpp1 heterodimer with the catalytic domain of RNase MRP. RNA. 2011;17:1922-31 pubmed publisher
    ..Here, we show that Pop5 and Rpp1, protein components found in both RNase P and RNase MRP, form a heterodimer that binds directly to the conserved ..
  7. Khanova E, Esakova O, Perederina A, Berezin I, Krasilnikov A. Structural organizations of yeast RNase P and RNase MRP holoenzymes as revealed by UV-crosslinking studies of RNA-protein interactions. RNA. 2012;18:720-8 pubmed publisher
    ..The results indicate locations of specific protein-binding sites in the RNA components of RNase P and RNase MRP and shed light on the structural organizations of these large ribonucleoprotein complexes. ..
  8. Houser Scott F, Xiao S, Millikin C, Zengel J, Lindahl L, Engelke D. Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. Proc Natl Acad Sci U S A. 2002;99:2684-9 pubmed
    ..This study provides a low-resolution map of the multisubunit architecture of the ribonucleoprotein enzyme, nuclear RNase P from S. cerevisiae. ..
  9. Coughlin D, Pleiss J, Walker S, Whitworth G, Engelke D. Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs. Proc Natl Acad Sci U S A. 2008;105:12218-23 pubmed publisher
    ..RNase P appears to participate in the splicing-independent path for the box C/D intron-encoded snoRNAs. ..

More Information


  1. Stolc V, Katz A, Altman S. Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1998;95:6716-21 pubmed
    ..cleave both yeast precursor tRNAs and precursor rRNAs accurately at the expected sites and contain the Rpp1 protein orthologue of the human scleroderma autoimmune antigen, Rpp30...
  2. Aspinall T, Gordon J, Bennett H, Karahalios P, Bukowski J, Walker S, et al. Interactions between subunits of Saccharomyces cerevisiae RNase MRP support a conserved eukaryotic RNase P/MRP architecture. Nucleic Acids Res. 2007;35:6439-50 pubmed
    ..The results provide further evidence of a conserved eukaryotic RNase P/MRP architecture and provide a strong basis for studies of enzyme assembly and subunit function. ..
  3. Hsieh J, Walker S, Fierke C, Engelke D. Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. RNA. 2009;15:224-34 pubmed publisher
    ..These data suggest that, despite marked differences in subunit composition, the minimal kinetic mechanism for cleavage of pre-tRNA catalyzed by yeast nuclear RNase P holoenzyme is similar to that of the bacterial RNase P holoenzyme. ..
  4. Lemieux B, Laterreur N, Perederina A, Noël J, Dubois M, Krasilnikov A, et al. Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP. Cell. 2016;165:1171-1181 pubmed publisher
    ..Thus, the same chaperoning module has allowed the evolution of functionally and, remarkably, structurally distinct RNPs, telomerase, and RNases P/MRP from unrelated progenitor RNAs. ..
  5. Esakova O, Perederina A, Berezin I, Krasilnikov A. Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate. Nucleic Acids Res. 2013;41:7084-91 pubmed publisher
    ..Implications for the structural organization of RNase MRP and the roles of its components are discussed. ..
  6. Stolc V, Altman S. Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Genes Dev. 1997;11:2926-37 pubmed
    ..The gene for this protein, RPP1, was identified by virtue of its homology with a human scleroderma autoimmune antigen, Rpp30, which copurifies with ..