Gene Symbol: RPN13
Description: proteasome regulatory particle lid subunit RPN13
Alias: proteasome regulatory particle lid subunit RPN13
Species: Saccharomyces cerevisiae S288c
Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, et al
. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature. 2008;453:481-8 pubmed publisher
..Here we report the identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome...
Lander G, Estrin E, Matyskiela M, Bashore C, Nogales E, Martin A. Complete subunit architecture of the proteasome regulatory particle. Nature. 2012;482:186-91 pubmed publisher
..We provide a structural basis for the ability of the proteasome to degrade a diverse set of substrates and thus regulate vital cellular processes. ..
Rosenzweig R, Bronner V, Zhang D, Fushman D, Glickman M. Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. J Biol Chem. 2012;287:14659-71 pubmed publisher
..Two neighboring subunits, Rpn10 and Rpn13, show a marked preference for polyubiquitin over UBLs...
Saeki Y, Isono E, Toh e A. Preparation of ubiquitinated substrates by the PY motif-insertion method for monitoring 26S proteasome activity. Methods Enzymol. 2005;399:215-27 pubmed
..In this communication, we describe that Sic1 was successfully ubiquitinated by the PY motif-insertion method and demonstrate that Sic1 thus ubiquitinated was degraded by the purified yeast 26S proteasome. ..
Brandina I, Smirnov A, Kolesnikova O, Entelis N, Krasheninnikov I, Martin R, et al
. tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system. FEBS Lett. 2007;581:4248-54 pubmed
..This result suggests a functional link between UPS and tRNA mitochondrial import in yeast and indicates on the existence of negative and positive import regulators. ..
Laporte D, Salin B, Daignan Fornier B, Sagot I. Reversible cytoplasmic localization of the proteasome in quiescent yeast cells. J Cell Biol. 2008;181:737-45 pubmed publisher
..Finally, we observe conserved formation and mobilization of these PSGs in the evolutionary distant yeast Schizosaccharomyces pombe. This conservation implies a broad significance for these proteasome reserves. ..
Saeki Y, Toh e A, Kudo T, Kawamura H, Tanaka K. Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell. 2009;137:900-13 pubmed publisher
..Our results indicate that the RP assembly is a highly organized and elaborate process orchestrated by multiple proteasome-dedicated chaperones. ..
Fatimababy A, Lin Y, Usharani R, Radjacommare R, Wang H, Tsai H, et al
. Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis. FEBS J. 2010;277:796-816 pubmed publisher
..proteasome-mediated proteolysis (UPP), which is mediated directly by the proteasome subunit RPN10 and/or RPN13, or indirectly by ubiquitin receptors containing ubiquitin-like and ubiquitin-associated domains...
Sakata E, Bohn S, Mihalache O, Kiss P, Beck F, Nagy I, et al
. Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2012;109:1479-84 pubmed publisher
Two canonical subunits of the 26S proteasome, Rpn10 and Rpn13, function as ubiquitin (Ub) receptors. The mutual arrangement of these subunits--and all other non-ATPase subunits--in the regulatory particle is unknown...