Gene Symbol: RPL7A
Description: ribosomal 60S subunit protein L7A
Alias: ribosomal 60S subunit protein L7A
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Mizuta K, Hashimoto T, Otaka E. The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins. Curr Genet. 1995;28:19-25 pubmed
    ..These are present in at least three species of yeast and seem to be functionally distinct from ribosomal proteins. ..
  2. Hsieh C, Huang S, Wu Y, Liu L, Han C, Liu Y, et al. Expression of proteins with dimethylarginines in Escherichia coli for protein-protein interaction studies. Protein Sci. 2007;16:919-28 pubmed
    ..Sbp1p and Sbp1p/hmt1 were covalently attached to solid supports for the isolation of interacting proteins. The results indicate that arginine methylation on Sbp1p exerts both positive and negative effects on protein-protein interaction. ..
  3. Kim T, Ha C, Huh W. Differential subcellular localization of ribosomal protein L7 paralogs in Saccharomyces cerevisiae. Mol Cells. 2009;27:539-46 pubmed publisher
    ..ribosomal protein L7, one of the approximately 46 ribosomal proteins of the 60S subunit, is encoded by paralogous RPL7A and RPL7B genes...
  4. Denison C, Rudner A, Gerber S, Bakalarski C, Moazed D, Gygi S. A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics. 2005;4:246-54 pubmed
    ..These data combine with recent works to further our understanding of the breadth and impact of protein sumoylation in a diverse array of biological processes. ..
  5. Rudra D, Zhao Y, Warner J. Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins. EMBO J. 2005;24:533-42 pubmed
    ..Homeostatic mechanisms within the cell respond by reducing the transcription of rRNA to match the output of RPs, and by reducing the global transcription of mRNA to match the capacity of the translational apparatus. ..
  6. Otaka E, Higo K, Itoh T. Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes. Mol Gen Genet. 1984;195:544-6 pubmed
    ..Comparison of the amino-terminal sequences with all other ribosomal protein sequences so far available indicates that YS9 shows sequence homology to rat liver ribosomal protein S8 (Wittmann-Liebold et al. 1979). ..
  7. Palumbo R, Fuchs G, Lutz S, Curcio M. Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae. G3 (Bethesda). 2017;7:591-606 pubmed publisher
    ..To determine whether paralog-specific phenotypes associated with deleting RPL7A or RPL7B stem from distinct functions or different levels of the encoded isoforms, the coding region ..
  8. Kispal G, Sipos K, Lange H, Fekete Z, Bedekovics T, Janaky T, et al. Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J. 2005;24:589-98 pubmed
    ..Thus, ribosome biogenesis and function are intimately linked to the crucial role of mitochondria in the maturation of the essential Fe/S protein Rli1p...
  9. Reineke L, Cao Y, Baus D, Hossain N, Merrick W. Insights into the role of yeast eIF2A in IRES-mediated translation. PLoS ONE. 2011;6:e24492 pubmed publisher
    ..These data suggest that eIF2A acts as a switch to regulate IRES-mediated translation, and eEF1A may be an important mediator of translational activation during ethanol stress. ..

More Information


  1. Jakovljevic J, Ohmayer U, Gamalinda M, Talkish J, ALEXANDER L, Linnemann J, et al. Ribosomal proteins L7 and L8 function in concert with six A? assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits. RNA. 2012;18:1805-22 pubmed publisher
    ..Thus, L7 and L8 might establish RNP structures within assembling ribosomes necessary for the stable association and function of the A(3) assembly factors and for proper assembly of the neighborhoods containing domains I and II. ..
  2. Wen F, Guo Y, Hu Y, Liu W, Wang Q, Wang Y, et al. Distinct temporal requirements for autophagy and the proteasome in yeast meiosis. Autophagy. 2016;12:671-88 pubmed publisher
    ..Our study defines the roles of autophagy and the proteasome in meiosis: Autophagy mainly affects the initiation of meiosis, whereas the proteasome mainly affects the 2 successive meiotic divisions. ..