Gene Symbol: RPL16B
Description: ribosomal 60S subunit protein L16B
Alias: RP23, ribosomal 60S subunit protein L16B
Species: Saccharomyces cerevisiae S288c
Rotenberg M, Moritz M, Woolford J. Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Genes Dev. 1988;2:160-72 pubmed
We constructed yeast strains containing deletion-insertion null alleles of the RPL16A or RPL16B genes encoding the 60S ribosomal subunit protein L16 to determine the role of L16 in the synthesis and function of ribosomes...
Rout M, Blobel G, Aitchison J. A distinct nuclear import pathway used by ribosomal proteins. Cell. 1997;89:715-25 pubmed
..We show that the related protein Pse1p is also a karyopherin and can functionally substitute for Kap123p; both are capable of specifically directing a ribosomal nuclear localization signal reporter to the nucleus in vivo. ..
Drummond S, Hildyard J, Firczuk H, Reamtong O, Li N, Kannambath S, et al
. Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes. Nucleic Acids Res. 2011;39:7764-74 pubmed publisher
..This reveals a new dimension to the relationship between translation activity and interactions between mRNA, the translation machinery and decapping activator proteins. ..
Lee J, Henry B, Yeh Y. Binding of proteins from the large ribosomal subunits to 5.8 S rRNA of Saccharomyces cerevisiae. J Biol Chem. 1983;258:854-8 pubmed
..The apparent association constants (K'a), measured at 4 degrees C and in 30 mM Tris-HCl, pH 7.4, 20 mM MgCl2, 330 mM KCl, and 6 mM beta-mercaptoethanol, ranged from 1.05 to 3.70 X 10(6) M-1. ..
Rosenblum J, Pemberton L, Blobel G. A nuclear import pathway for a protein involved in tRNA maturation. J Cell Biol. 1997;139:1655-61 pubmed
..In addition, through its association with ribosomal proteins, Sxm1p may have a role in coordinating ribosome biogenesis with tRNA processing. ..
Halbeisen R, Scherrer T, Gerber A. Affinity purification of ribosomes to access the translatome. Methods. 2009;48:306-10 pubmed publisher
..Finally, application of this method in other organisms provides a valuable tool to decipher cell-type specific gene expression patterns. ..
Armakola M, Higgins M, Figley M, Barmada S, Scarborough E, Diaz Z, et al
. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012;44:1302-9 pubmed publisher
..Our findings provide insight into TDP-43-mediated cytotoxicity and suggest that decreasing Dbr1 activity could be a potential therapeutic approach for ALS. ..
Loibl M, Klein I, Prattes M, Schmidt C, Kappel L, Zisser G, et al
. The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. J Biol Chem. 2014;289:3913-22 pubmed publisher
..Our results identify the first target of an inhibitor of ribosome biogenesis and provide the mechanism of inhibition of a key step in large ribosomal subunit formation. ..