RPL16A

Summary

Gene Symbol: RPL16A
Description: ribosomal 60S subunit protein L16A
Alias: RPL13, ribosomal 60S subunit protein L16A
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Van Dyke M, Nelson L, Weilbaecher R, Mehta D. Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. J Biol Chem. 2004;279:24323-33 pubmed
    ..We discuss the implications of our findings in relation to prior genetic, genomic, and proteomic studies that have identified STM1 and/or Stm1p as well as the possible biological role of Stm1p. ..
  2. Rotenberg M, Moritz M, Woolford J. Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Genes Dev. 1988;2:160-72 pubmed
    We constructed yeast strains containing deletion-insertion null alleles of the RPL16A or RPL16B genes encoding the 60S ribosomal subunit protein L16 to determine the role of L16 in the synthesis and function of ribosomes...
  3. Rout M, Blobel G, Aitchison J. A distinct nuclear import pathway used by ribosomal proteins. Cell. 1997;89:715-25 pubmed
    ..We show that the related protein Pse1p is also a karyopherin and can functionally substitute for Kap123p; both are capable of specifically directing a ribosomal nuclear localization signal reporter to the nucleus in vivo. ..
  4. Kispal G, Sipos K, Lange H, Fekete Z, Bedekovics T, Janaky T, et al. Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J. 2005;24:589-98 pubmed
    ..Thus, ribosome biogenesis and function are intimately linked to the crucial role of mitochondria in the maturation of the essential Fe/S protein Rli1p...
  5. Honma Y, Kitamura A, Shioda R, Maruyama H, Ozaki K, Oda Y, et al. TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. EMBO J. 2006;25:3832-42 pubmed
    ..Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR. This is the first description of a physiological regulation of nucleolus-to-nucleoplasm translocation of pre-ribosome complexes. ..
  6. Halbeisen R, Scherrer T, Gerber A. Affinity purification of ribosomes to access the translatome. Methods. 2009;48:306-10 pubmed publisher
    ..Finally, application of this method in other organisms provides a valuable tool to decipher cell-type specific gene expression patterns. ..
  7. Halbach A, Zhang H, Wengi A, Jablonska Z, Gruber I, Halbeisen R, et al. Cotranslational assembly of the yeast SET1C histone methyltransferase complex. EMBO J. 2009;28:2959-70 pubmed publisher
  8. Drummond S, Hildyard J, Firczuk H, Reamtong O, Li N, Kannambath S, et al. Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes. Nucleic Acids Res. 2011;39:7764-74 pubmed publisher
    ..This reveals a new dimension to the relationship between translation activity and interactions between mRNA, the translation machinery and decapping activator proteins. ..
  9. del Alamo M, Hogan D, Pechmann S, Alban├Ęse V, Brown P, Frydman J. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. PLoS Biol. 2011;9:e1001100 pubmed publisher
    ..The strategy we used should be generally applicable to mapping the specificity, interplay, and dynamics of the cotranslational protein homeostasis network. ..

More Information

Publications12

  1. Loibl M, Klein I, Prattes M, Schmidt C, Kappel L, Zisser G, et al. The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. J Biol Chem. 2014;289:3913-22 pubmed publisher
    ..Our results identify the first target of an inhibitor of ribosome biogenesis and provide the mechanism of inhibition of a key step in large ribosomal subunit formation. ..
  2. Lee J, Henry B, Yeh Y. Binding of proteins from the large ribosomal subunits to 5.8 S rRNA of Saccharomyces cerevisiae. J Biol Chem. 1983;258:854-8 pubmed
    ..The apparent association constants (K'a), measured at 4 degrees C and in 30 mM Tris-HCl, pH 7.4, 20 mM MgCl2, 330 mM KCl, and 6 mM beta-mercaptoethanol, ranged from 1.05 to 3.70 X 10(6) M-1. ..
  3. Armakola M, Higgins M, Figley M, Barmada S, Scarborough E, Diaz Z, et al. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012;44:1302-9 pubmed publisher
    ..Our findings provide insight into TDP-43-mediated cytotoxicity and suggest that decreasing Dbr1 activity could be a potential therapeutic approach for ALS. ..