Gene Symbol: RPD3
Description: histone deacetylase RPD3
Alias: MOF6, REC3, SDI2, SDS6, histone deacetylase RPD3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Knott S, Viggiani C, Tavare S, Aparicio O. Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev. 2009;23:1077-90 pubmed publisher
    ..In Saccharomyces cerevisiae, the histone deacetylase Rpd3 regulates gene expression and also modulates replication timing; however, these mechanisms have been ..
  2. Tsang C, Bertram P, Ai W, Drenan R, Zheng X. Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR. EMBO J. 2003;22:6045-56 pubmed
    ..We also present evidence that TOR regulates association of Rpd3-Sin3 histone deacetylase (HDAC) with rDNA chromatin, leading to site-specific deacetylation of histone H4...
  3. Zhang Z, Reese J. Redundant mechanisms are used by Ssn6-Tup1 in repressing chromosomal gene transcription in Saccharomyces cerevisiae. J Biol Chem. 2004;279:39240-50 pubmed
    ..Thus, Tup1 utilizes multiple redundant mechanisms to repress transcription of native genes, which may be important for it to act as a global corepressor at a wide variety of promoters. ..
  4. Kurdistani S, Robyr D, Tavazoie S, Grunstein M. Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet. 2002;31:248-54 pubmed
    We describe the genome-wide distribution of the histone deacetylase and repressor Rpd3 and its associated proteins Ume1 and Ume6 in Saccharomyces cerevisiae...
  5. Sharma V, Tomar R, Dempsey A, Reese J. Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. Mol Cell Biol. 2007;27:3199-210 pubmed
    ..We show that two HDACs, RPD3 and HOS2, are required for the activation of DNA damage-inducible genes RNR3 and HUG1...
  6. Takahata S, Yu Y, Stillman D. The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters. EMBO J. 2009;28:3378-89 pubmed publisher
    ..Our chromatin immunoprecipitation (ChIP) experiments show that SBF, Whi5 and Stb1 recruit both Cdc28 and the Rpd3(L) histone deacetylase to CLN promoters, extending the analogy with mammalian G1 cyclin promoters in which Rb ..
  7. Florens L, Carozza M, Swanson S, Fournier M, Coleman M, Workman J, et al. Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors. Methods. 2006;40:303-11 pubmed
    ..In this method review, we describe a reanalysis of the Rpd3/Sin3 small and large histone deacetylase complexes previously described in a tabular form to demonstrate the ..
  8. Xin X, Lan C, Lee H, Zhang L. Regulation of the HAP1 gene involves positive actions of histone deacetylases. Biochem Biophys Res Commun. 2007;362:120-5 pubmed
    ..Intriguingly, we found that histone deacetylases, including Rpd3, Hda1, Sin3 and Hos1, are not required for the repression of the HAP1 gene by Hap1...
  9. Lechner T, Carrozza M, Yu Y, Grant P, Eberharter A, Vannier D, et al. Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. J Biol Chem. 2000;275:40961-6 pubmed
    ..In addition, sds3 mutants have phenotypes very similar to those seen in sin3 and rpd3 mutants, suggesting that it functions in the same genetic pathway...

More Information


  1. Rundlett S, Carmen A, Kobayashi R, Bavykin S, Turner B, Grunstein M. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A. 1996;93:14503-8 pubmed
    ..The HDA1 protein (a subunit of the HDA activity) shares sequence similarity to RPD3, a factor required for optimal transcription of certain yeast genes. RPD3 is associated with the HDB activity...
  2. Kadosh D, Struhl K. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell. 1997;89:365-71 pubmed
    Sin3 and Rpd3 negatively regulate a diverse set of yeast genes. A mouse Sin3-related protein is a transcriptional corepressor, and a human Rpd3 homolog is a histone deacetylase...
  3. Burgess S, Ajimura M, Kleckner N. GCN5-dependent histone H3 acetylation and RPD3-dependent histone H4 deacetylation have distinct, opposing effects on IME2 transcription, during meiosis and during vegetative growth, in budding yeast. Proc Natl Acad Sci U S A. 1999;96:6835-40 pubmed
    ..In contrast, the RPD3 gene, which encodes a histone H4 deacetylase and is known to be required for repression of basal IME2 transcription ..
  4. Biswas D, Takahata S, Stillman D. Different genetic functions for the Rpd3(L) and Rpd3(S) complexes suggest competition between NuA4 and Rpd3(S). Mol Cell Biol. 2008;28:4445-58 pubmed publisher
    b>Rpd3(L) and Rpd3(S) are distinct multisubunit complexes containing the Rpd3 histone deacetylase...
  5. Oakes M, Siddiqi I, French S, Vu L, Sato M, Aris J, et al. Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast. Mol Cell Biol. 2006;26:3889-901 pubmed
    ..We found that deletion of histone deacetylase gene RPD3 inhibits the appearance of PSW variants in rrn9 deletion mutants...
  6. Kremer S, Gross D. SAGA and Rpd3 chromatin modification complexes dynamically regulate heat shock gene structure and expression. J Biol Chem. 2009;284:32914-31 pubmed publisher
    ..Robust and rapid recruitment of repressive, Rpd3-containing histone deacetylase complexes was also seen and at all HSP genes examined...
  7. Scott K, Plon S. Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae. Mol Cell Biol. 2003;23:4522-31 pubmed
    ..cerevisiae Sin3/Rpd3 histone deacetylase complex...
  8. Arevalo Rodriguez M, Cardenas M, Wu X, Hanes S, Heitman J. Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. EMBO J. 2000;19:3739-49 pubmed
    ..Using genetic and biochemical approaches, we found that one of these targets is the Sin3-Rpd3 histone deacetylase complex, and that cyclophilin A increases and Ess1 decreases disruption of gene silencing by ..
  9. Keogh M, Kurdistani S, Morris S, Ahn S, Podolny V, Collins S, et al. Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell. 2005;123:593-605 pubmed
    The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two distinct complexes...
  10. Davie J, Edmondson D, Coco C, Dent S. Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem. 2003;278:50158-62 pubmed
    ..Here, we describe physical interactions of the corepressor complex with the class I HDACs Rpd3, Hos2, and Hos1. In contrast, no in vivo interaction was observed between Tup-Ssn6 and Hda1, a class II HDAC...
  11. Rundlett S, Carmen A, Suka N, Turner B, Grunstein M. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature. 1998;392:831-5 pubmed
    The histone deacetylase RPD3 can be targeted to certain genes through its interaction with DNA-binding regulatory proteins. RPD3 can then repress gene transcription...
  12. Quan T, Hartzog G. Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription. Genetics. 2010;184:321-34 pubmed publisher
  13. Tsang C, Li H, Zheng X. Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J. 2007;26:448-58 pubmed
    ..b>Rpd3-dependent histone deacetylation is necessary and sufficient for condensin's relocalization and loading to rDNA ..
  14. Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein K, Rothstein R, et al. HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature. 2011;471:74-79 pubmed publisher
    ..Two HDACs, Hda1 and Rpd3, and one HAT, Gcn5, have key roles in these processes...
  15. Merker J, Dominska M, Greenwell P, Rinella E, Bouck D, Shibata Y, et al. The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst). 2008;7:1298-308 pubmed publisher
    ..The increase of HIS4 hotspot activity in set2 and rpd3 strains is likely to be related to the recent finding that histone H3 methylation by Set2p directs deacetylation of ..
  16. Kadosh D, Struhl K. Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 1998;12:797-805 pubmed
    Eukaryotic organisms from yeast to human contain a multiprotein complex that includes Rpd3 histone deacetylase and Sin3 corepressor...
  17. Marsellach F, Huertas D, Azorín F. The multi-KH domain protein of Saccharomyces cerevisiae Scp160p contributes to the regulation of telomeric silencing. J Biol Chem. 2006;281:18227-35 pubmed
    ..telomere clustering at the nuclear envelope is perturbed in Deltascp160 cells and disruption of the histone deacetylase RPD3, which is known to improve telomere clustering, rescues telomeric silencing in Deltascp160 cells...
  18. Bumgarner S, Dowell R, Grisafi P, Gifford D, Fink G. Toggle involving cis-interfering noncoding RNAs controls variegated gene expression in yeast. Proc Natl Acad Sci U S A. 2009;106:18321-6 pubmed publisher
  19. Smith J, Caputo E, Boeke J. A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol Cell Biol. 1999;19:3184-97 pubmed
    ..Mutations in the HDB (RPD3) histone deacetylase complex paradoxically increased rDNA silencing by a SIR2-dependent, SIR3-independent mechanism...
  20. Lickwar C, Rao B, Shabalin A, Nobel A, Strahl B, Lieb J. The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency. PLoS ONE. 2009;4:e4886 pubmed publisher
    ..These new results and conclusions have implications for many commonly used genomic analysis approaches, and for the evolution of high-fidelity RNA polymerase II transcriptional initiation in eukaryotes. ..
  21. Inai T, Yukawa M, Tsuchiya E. Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis. Mol Cell Biol. 2007;27:1254-63 pubmed
    ..is repressed during mitosis through the repressive chromatin structure at the promoter, which is maintained by the Rpd3-Sin3 histone deacetylase (HDAC) complex...
  22. Vogelauer M, Rubbi L, Lucas I, Brewer B, Grunstein M. Histone acetylation regulates the time of replication origin firing. Mol Cell. 2002;10:1223-33 pubmed
    ..Deletion of RPD3 histone deacetylase causes earlier origin firing and concurrent binding of the replication factor Cdc45p to origins...
  23. Wang H, Carey L, Cai Y, Wijnen H, Futcher B. Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets. PLoS Biol. 2009;7:e1000189 pubmed publisher
    ..The Rpd3 histone deacetylase complex is also involved...
  24. Tompa R, Madhani H. Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics. 2007;175:585-93 pubmed
    ..Thus, antagonism of silencing is independent of the only known effector of this conserved histone modification. ..
  25. Loewith R, Smith J, Meijer M, Williams T, Bachman N, Boeke J, et al. Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. J Biol Chem. 2001;276:24068-74 pubmed
    The Rpd3 histone deacetylase (HDAC) functions in a large complex containing many proteins including Sin3 and Sap30. Previous evidence indicates that the pho23, rpd3, sin3, and sap30 mutants exhibit similar defects in PHO5 regulation...
  26. Kadosh D, Struhl K. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol. 1998;18:5121-7 pubmed
    Eukaryotic organisms contain a multiprotein complex that includes Rpd3 histone deacetylase and the Sin3 corepressor. The Sin3-Rpd3 complex is recruited to promoters by specific DNA-binding proteins, whereupon it represses transcription...
  27. Wang A, Kurdistani S, Grunstein M. Requirement of Hos2 histone deacetylase for gene activity in yeast. Science. 2002;298:1412-4 pubmed
    Histone deacetylases, typified by class I Rpd3 in the yeast Saccharomyces cerevisiae, have historically been associated with gene repression...
  28. Kasten M, Dorland S, Stillman D. A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol Cell Biol. 1997;17:4852-8 pubmed
    ..Genetic studies have shown that the yeast RPD3 gene has a function similar to that of SIN3 in transcriptional regulation, as SIN3 and RPD3 negatively regulate the ..
  29. Borecka Melkusova S, Kozovska Z, Hikkel I, Dzugasova V, Subik J. RPD3 and ROM2 are required for multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res. 2008;8:414-24 pubmed publisher
    ..In this work, it is shown that the RPD3 gene encoding the histone deacetylase that functions as a transcriptional corepressor at many promoters and the ..
  30. Mallory M, Strich R. Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. J Biol Chem. 2003;278:44727-34 pubmed
    ..In addition, these results suggest that Rpd3-Ume1p-Sin3p comprises an interdependent complex required for mediating transcriptional repression.
  31. Sun Z, Hampsey M. A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Genetics. 1999;152:921-32 pubmed
    The Sin3-Rpd3 histone deacetylase complex, conserved between human and yeast, represses transcription when targeted by promoter-specific transcription factors...
  32. Aparicio J, Viggiani C, Gibson D, Aparicio O. The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. Mol Cell Biol. 2004;24:4769-80 pubmed
    ..Deletion of the histone deacetylase Rpd3 or its interacting partner Sin3 caused early activation of late origins at internal chromosomal loci but ..
  33. de Nadal E, Zapater M, Alepuz P, Sumoy L, Mas G, Posas F. The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature. 2004;427:370-4 pubmed
    ..Cells lacking the Rpd3-Sin3 histone deacetylase complex are sensitive to high osmolarity and show compromised expression of osmostress ..
  34. Fazzio T, Kooperberg C, Goldmark J, Neal C, Basom R, Delrow J, et al. Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol Cell Biol. 2001;21:6450-60 pubmed
    The yeast Isw2 chromatin remodeling complex functions in parallel with the Sin3-Rpd3 histone deacetylase complex to repress early meiotic genes upon recruitment by Ume6p...
  35. Sertil O, Vemula A, Salmon S, Morse R, Lowry C. Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast. Mol Cell Biol. 2007;27:2037-47 pubmed
    ..to enhance repression of the DAN/TIR genes, we found that the histone deacetylase and global repressor complex, Rpd3-Sin3-Sap30, was not required for repression. Strikingly, the complex was instead required for activation...
  36. Ehrentraut S, Weber J, Dybowski J, Hoffmann D, Ehrenhofer Murray A. Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. Proc Natl Acad Sci U S A. 2010;107:5522-7 pubmed publisher
    ..Significantly, the histone deacetylase (HDAC) Rpd3 was necessary for boundary formation in Saccharomyces cerevisiae...
  37. Huang D, Kaluarachchi S, van Dyk D, Friesen H, Sopko R, Ye W, et al. Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. PLoS Biol. 2009;7:e1000188 pubmed publisher
    ..tests suggest Whi5 mediates repression in part through interaction with two histone deacetylases (HDACs), Hos3 and Rpd3. In a manner analogous to cyclin D/CDK4/6, which phosphorylates Rb in mammalian cells disrupting its association ..
  38. Lottersberger F, Panza A, Lucchini G, Longhese M. Functional and physical interactions between yeast 14-3-3 proteins, acetyltransferases, and deacetylases in response to DNA replication perturbations. Mol Cell Biol. 2007;27:3266-81 pubmed
    ..Conversely, the lack of the histone deacetylase subunit Rpd3 or Sin3 partially suppresses the hypersensitivity to HU of bmh mutants and restores their ability to complete DNA ..
  39. Lamb T, Mitchell A. Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3. Genetics. 2001;157:545-56 pubmed
    ..One of these mutations is in RPD3, a gene required to maintain meiotic gene repression in mitotic cells...
  40. Carrozza M, Li B, Florens L, Suganuma T, Swanson S, Lee K, et al. Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell. 2005;123:581-92 pubmed
    Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis...
  41. Watson A, Edmondson D, Bone J, Mukai Y, Yu Y, Du W, et al. Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 2000;14:2737-44 pubmed
    ..that histone hyperacetylation caused by combined mutations in genes encoding the histone deacetylases (HDACs) Rpd3, Hos1, and Hos2 abolishes Ssn6-Tup1 repression...
  42. Govind C, Qiu H, Ginsburg D, Ruan C, Hofmeyer K, Hu C, et al. Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Mol Cell. 2010;39:234-46 pubmed publisher
    ..We further demonstrate that Rpd3, Hos2, and Hda1 have overlapping functions in deacetylating histones and suppressing cotranscriptional histone ..
  43. Veis J, Klug H, Koranda M, Ammerer G. Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals. Mol Cell Biol. 2007;27:8364-73 pubmed
    ..Sin3 and its catalytic subunit Rpd3 associate with the CLB2 promoter during the G1 phase of the cell cycle...
  44. Goldmark J, Fazzio T, Estep P, Church G, Tsukiyama T. The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell. 2000;103:423-33 pubmed
    ..Isw2 complex represses transcription of early meiotic genes during mitotic growth in a parallel pathway to Rpd3-Sin3 histone deacetylase complex...
  45. Li B, Gogol M, Carey M, Lee D, Seidel C, Workman J. Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin. Science. 2007;316:1050-4 pubmed
    ..Thus, the coupled chromo and PHD domains of Rpd3S specify recognition of the methyl H3K36 mark, demonstrating the first combinatorial domain requirement within a protein complex to read a specific histone code. ..
  46. Vannier D, Balderes D, Shore D. Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Genetics. 1996;144:1343-53 pubmed
    ..SDS16 and SDS6 are known transcriptional modifiers, SIN3(RPD1/UME4/SDI1/GAM2) and RPD3(SDI2), respectively, while the third is a novel gene, SDS3...
  47. Carrozza M, Florens L, Swanson S, Shia W, Anderson S, Yates J, et al. Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta. 2005;1731:77-87; discussion 75-6 pubmed
    Histone deacetylation by Saccharomyces cerevisiae Rpd3 represses genes regulated by the Ash1 and Ume6 DNA-binding proteins. Rpd3 exists in a small 0.6 MDa (Rpd3S) and large 1.2 MDa (Rpd3L) corepressor complex...
  48. Zhou J, Zhou B, Lenzmeier B, Zhou J. Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res. 2009;37:3699-713 pubmed publisher
    ..In rpd3 Delta cells, the amount of Sir2p that was normally found in the nucleolus decreased and the amount of Sir2p found ..
  49. Poschke H, Dees M, Chang M, Amberkar S, Kaderali L, Rothstein R, et al. Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast. PLoS Genet. 2012;8:e1002960 pubmed publisher
    ..In the absence of Rpd3 function, telomeres have an increased susceptibility to nucleolytic degradation, telomere loss, and the initiation ..
  50. Lin L, Minard L, Johnston G, Singer R, Schultz M. Asf1 can promote trimethylation of H3 K36 by Set2. Mol Cell Biol. 2010;30:1116-29 pubmed publisher
    ..This function of Asf1 promotes the switch from di- to trimethylation of H3 K36 at that gene. These results support the view that Set2 function in chromatin metabolism can intimately involve histone chaperone Asf1. ..
  51. Bastos de Oliveira F, Harris M, Brazauskas P, de Bruin R, Smolka M. Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes. EMBO J. 2012;31:1798-810 pubmed publisher
    ..Our results reveal that replication stress induces expression of G1/S genes via the Rad53-MBF pathway and that an SBF-to-MBF switch characterizes a new class of genes that can be induced by replication stress. ..
  52. Vannier D, Damay P, Shore D. A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae. Mol Genet Genomics. 2001;265:560-8 pubmed
    ..probably reflects an important or essential role for Sds3p in the Rpd3p/Sin3p histone deacetylase complex, since RPD3 and SIN3 mutations are also synthetically lethal in combination with swi6 and these phenotypes are also rescued by ..
  53. Dekker J. GC- and AT-rich chromatin domains differ in conformation and histone modification status and are differentially modulated by Rpd3p. Genome Biol. 2007;8:R116 pubmed
    ..Isochore domains differ in gene expression levels, replication timing, levels of meiotic recombination and chromatin structure. The molecular basis for these differences is poorly understood...
  54. Drouin S, Laramée L, Jacques P, Forest A, Bergeron M, Robert F. DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. PLoS Genet. 2010;6:e1001173 pubmed publisher
    b>Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes...
  55. Vidal M, Gaber R. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11:6317-27 pubmed
    ..Recessive mutations in RPD1 and RPD3 suppress the TRK2, conferring an approximately fourfold increase in transcription...
  56. Demin A, Lee M, Lee C, Seo Y. GSK-3? Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2. Genetics. 2017;206:829-842 pubmed publisher
    ..We found that the interaction of Ume6 with the conserved histone deacetylase complex Sin3-Rpd3 and the catalytic activity of Rpd3 were indispensable for the observed suppression of the dna2 mutant...
  57. Weinberger L, Voichek Y, Tirosh I, Hornung G, Amit I, Barkai N. Expression noise and acetylation profiles distinguish HDAC functions. Mol Cell. 2012;47:193-202 pubmed publisher
    ..Distinct activities of the Rpd3(L) and Set3 histone deacetylase complexes were predicted. Both HDACs repressed expression...
  58. Eustice M, Pillus L. Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics. 2014;196:1029-39 pubmed publisher
    ..Our analysis thus uncovers previously unsuspected functions for both Gas1 and Sas3 in DNA damage response and cell cycle regulation. ..