Genomes and Genes
Gene Symbol: RPC19
Description: DNA-directed RNA polymerase core subunit RPC19
Alias: DNA-directed RNA polymerase core subunit RPC19
Species: Saccharomyces cerevisiae S288c
- Todaka Y, Wang Y, Tashiro K, Nakashima N, Nishimoto T, Sekiguchi T. Association of the GTP-binding protein Gtr1p with Rpc19p, a shared subunit of RNA polymerase I and III in yeast Saccharomyces cerevisiae. Genetics. 2005;170:1515-24 pubmed..Here, we propose that Gtr1p is involved in RNA polymerase I and III assembly by its association with Rpc19p and could be a mediator that links growth regulatory signals with ribosome biogenesis. ..
- Keener J, Josaitis C, Dodd J, Nomura M. Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem. 1998;273:33795-802 pubmed..The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription. ..
- Kuhn C, Geiger S, Baumli S, Gartmann M, Gerber J, Jennebach S, et al. Functional architecture of RNA polymerase I. Cell. 2007;131:1260-72 pubmed..In contrast to Pol II, Pol I has a strong intrinsic 3'-RNA cleavage activity, which requires the C-terminal domain of subunit A12.2 and, apparently, enables ribosomal RNA proofreading and 3'-end trimming. ..
- Vernekar D, Bhargava P. Yeast Bud27 modulates the biogenesis of Rpc128 and Rpc160 subunits and the assembly of RNA polymerase III. Biochim Biophys Acta. 2015;1849:1340-53 pubmed publisher..Our results show that Bud27 is required in multiple activities responsible for pol III biogenesis and activity. ..