Gene Symbol: ROY1
Species: Saccharomyces cerevisiae S288c
Yen J, Flick K, Papagiannis C, Mathur R, Tyrrell A, Ouni I, et al
. Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97. Mol Cell. 2012;48:288-97 pubmed publisher
..Our results not only provide an additional layer of ubiquitin ligase regulation but also suggest that targeted, signal-dependent dissociation of multisubunit enzyme complexes is an important mechanism in control of enzyme function. ..
Parrish W, Stefan C, Emr S. PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway. J Cell Sci. 2005;118:5589-601 pubmed
..Taken together, the results of this study indicated that aberrant Rho1p/Pkc1p signaling contributes to the lethal effects of PtdIns(3)P accumulation in cells deficient in PI 3-phosphatase activity. ..
Hwang G, Wada N, Kuge S, Naganuma A. Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae. J Toxicol Sci. 2009;34:413-6 pubmed
..The overexpression of Ymr258c might promote the ubiquitination of proteins that are involved in the enhancement of methylmercury toxicity, and thereby promote their degradation by proteasomes to reduce methylmercury toxicity. ..
Aghajan M, Jonai N, Flick K, Fu F, Luo M, Cai X, et al
. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010;28:738-42 pubmed publisher
..Our results show that there is no fundamental barrier to obtaining specific inhibitors to modulate function of individual SCF complexes. ..
Liu Y, Nakatsukasa K, Kotera M, Kanada A, Nishimura T, Kishi T, et al
. Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function. Mol Biol Cell. 2011;22:1575-84 pubmed publisher
..Here we analyze the role of a previously uncharacterized non-SCF-type F-box protein, Roy1/Ymr258c, in cell growth and intracellular transport in Saccharomyces cerevisiae...