Gene Symbol: ROD1
Description: Rod1p
Alias: ART4, Rod1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Andoh T, Hirata Y, Kikuchi A. PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. FEBS Lett. 2002;525:131-4 pubmed
    In Saccharomyces cerevisiae, the overexpression of ROD1 confers resistance to o-dinitrobenzene (o-DNB), a representative of target drugs of glutathione S-transferase. The roles of Rod1 in drug resistance have remained to be determined...
  2. Lin C, MacGurn J, Chu T, Stefan C, Emr S. Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell. 2008;135:714-25 pubmed publisher
    ..We propose that ARTs provide a cargo-specific quality-control pathway that mediates endocytic downregulation by coupling Rsp5/Nedd4 to diverse plasma membrane proteins. ..
  3. Shinoda J, Kikuchi Y. Rod1, an arrestin-related protein, is phosphorylated by Snf1-kinase in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2007;364:258-63 pubmed
    ..In Saccharomyces cerevisiae, there are several arrestin-related proteins. One of those proteins, Rod1, has been identified to have the ability to confer resistance to o-dinitrobenzene...
  4. Bilsland E, Molin C, Swaminathan S, Ramne A, Sunnerhagen P. Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Mol Microbiol. 2004;53:1743-56 pubmed
    ..Zrc1 co-immunoprecipitates with Rck2, and ZRC1 is genetically downstream of RCK2. These data connect activation of the Hog1 MAPK cascade with effectors having a role in oxidative stress resistance. ..
  5. Becuwe M, Vieira N, Lara D, Gomes Rezende J, Soares Cunha C, Casal M, et al. A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol. 2012;196:247-59 pubmed publisher
    ..We show that this required the conserved arrestin-related protein Rod1/Art4, which was activated in response to glucose addition...
  6. Alvaro C, O Donnell A, Prosser D, Augustine A, Goldman A, Brodsky J, et al. Specific ?-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2. Mol Cell Biol. 2014;34:2660-81 pubmed
    ..Here, we demonstrate that three different members of the ?-arrestin family (Ldb19/Art1, Rod1/Art4, and Rog3/Art7) contribute to Ste2 desensitization and internalization, and they do so by discrete mechanisms...
  7. O Donnell A, McCartney R, Chandrashekarappa D, Zhang B, Thorner J, Schmidt M. 2-Deoxyglucose impairs Saccharomyces cerevisiae growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3. Mol Cell Biol. 2015;35:939-55 pubmed publisher
    ..2DG-stimulated trafficking of Hxt1 and Hxt3 requires Rod1/Art4 and Rog3/Art7, two members of the α-arrestin trafficking adaptor family...
  8. Llopis Torregrosa V, Ferri Blázquez A, Adam Artigues A, Deffontaines E, Van Heusden G, Yenush L. Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 ?-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein. J Biol Chem. 2016;291:14973-85 pubmed publisher
    ..Specifically, Rod1 (Art4) has been reported to regulate the endocytosis of both the Hxt1, Hxt3, and Hxt6 glucose transporters and the ..
  9. Wu A, Hallstrom T, Moye Rowley W. ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae. J Biol Chem. 1996;271:2914-20 pubmed
    ..An epitope-tagged version of Rod1p was produced in S. cerevisiae and shown to function properly...

More Information


  1. Prosser D, Pannunzio A, Brodsky J, Thorner J, Wendland B, O Donnell A. α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. J Cell Sci. 2015;128:4220-34 pubmed publisher
    ..Notably, neither expression of Rsp5 nor its binding to α-arrestins is required for CIE. Thus, α-arrestins are important for cargo selection in both the CME and CIE pathways, but function by distinct mechanisms in each pathway. ..
  2. Alvaro C, Aindow A, Thorner J. Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae. Genetics. 2016;203:299-317 pubmed publisher
    ..agonist-stimulated internalization of Ste2 requires its association with an adaptor protein, the α-arrestin Rod1/Art4, which recruits the HECT-domain ubiquitin ligase Rsp5, allowing for ubiquitinylation of the C-terminal tail of the ..
  3. Talaia G, Gournas C, Saliba E, Barata Antunes C, Casal M, Andre B, et al. The ?-Arrestin Bul1p Mediates Lactate Transporter Endocytosis in Response to Alkalinization and Distinct Physiological Signals. J Mol Biol. 2017;429:3678-3695 pubmed publisher
    ..Our results support a model where conformational changes of Jen1p, associated with substrate/H+ symport, are critical for the efficiency of Bul1p-dependent Jen1p turnover...