Gene Symbol: RLI1
Description: Fe-S cluster-binding ribosome biosynthesis protein
Alias: Fe-S cluster-binding ribosome biosynthesis protein
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Yarunin A, Panse V, Petfalski E, Dez C, Tollervey D, Hurt E. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. EMBO J. 2005;24:580-8 pubmed
    ..In particular, Nar1 was implicated to generate the Fe-S clusters within Rli1, a potential substrate protein of unknown function...
  2. Kispal G, Sipos K, Lange H, Fekete Z, Bedekovics T, Janaky T, et al. Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J. 2005;24:589-98 pubmed
    ..Thus, ribosome biogenesis and function are intimately linked to the crucial role of mitochondria in the maturation of the essential Fe/S protein Rli1p...
  3. Khoshnevis S, Gross T, Rotte C, Baierlein C, Ficner R, Krebber H. The iron-sulphur protein RNase L inhibitor functions in translation termination. EMBO Rep. 2010;11:214-9 pubmed publisher
    The iron-sulphur (Fe-S)-containing RNase L inhibitor (Rli1) is involved in ribosomal subunit maturation, transport of both ribosomal subunits to the cytoplasm, and translation initiation through interaction with the eukaryotic initiation ..
  4. Dong J, Lai R, Nielsen K, Fekete C, Qiu H, Hinnebusch A. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem. 2004;279:42157-68 pubmed
    b>RLI1 is an essential yeast protein closely related in sequence to two soluble members of the ATP-binding cassette family of proteins that interact with ribosomes and function in translation elongation (YEF3) or translational control (..
  5. Shoemaker C, Green R. Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. Proc Natl Acad Sci U S A. 2011;108:E1392-8 pubmed publisher
    ..in vitro reconstituted yeast translation system, we identify a key role for the multifunctional ABC-family protein Rli1 in stimulating both eRF1-mediated termination and ribosome recycling in yeast...
  6. van den Elzen A, Schuller A, Green R, Seraphin B. Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress. EMBO J. 2014;33:265-76 pubmed publisher
    ..The Dom34-Hbs1 complex, together with the Rli1 NTPase (also known as ABCE1), have been shown to split ribosomes stuck on mRNAs in the context of RNA quality ..
  7. Young D, Guydosh N, Zhang F, Hinnebusch A, Green R. Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo. Cell. 2015;162:872-84 pubmed publisher
    To study the function of Rli1/ABCE1 in vivo, we used ribosome profiling and biochemistry to characterize its contribution to ribosome recycling...
  8. Alhebshi A, Sideri T, Holland S, Avery S. The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species. Mol Biol Cell. 2012;23:3582-90 pubmed publisher
    ..Furthermore, prooxidant resistance was decreased by RLI1 repression and increased by RLI1 overexpression...
  9. Beznosková P, Cuchalová L, Wagner S, Shoemaker C, Gunisova S, von der Haar T, et al. Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells. PLoS Genet. 2013;9:e1003962 pubmed publisher
    ..eIF3 and HCR1 also occur in ribosome- and RNA-free complexes with both eRFs and the recycling factor ABCE1/RLI1. Several eIF3 mutations reduce rates of stop codon read-through and genetically interact with mutant eRFs...

More Information


  1. Paul V, Mühlenhoff U, Stümpfig M, Seebacher J, Kugler K, Renicke C, et al. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. elife. 2015;4:e08231 pubmed publisher
    ..Depletion of Yae1 or Lto1 results in defective Fe-S maturation of the ribosome-associated ABC protein Rli1, but surprisingly no other tested targets...
  2. Zhai C, Li Y, Mascarenhas C, Lin Q, Li K, Vyrides I, et al. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Oncogene. 2014;33:484-94 pubmed publisher
    ..Lto1 is found in a complex with Rli1/ABCE1, an ATP-binding cassette (ABC)-ATPase bearing N-terminal [4Fe-4S] clusters...
  3. Burugula B, Jeronimo C, Pathak R, Jones J, Robert F, Govind C. Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly. Mol Cell Biol. 2014;34:4115-29 pubmed publisher
    ..Collectively, our results show that a complex network of interactions, involving the Spt6 tSH2 domain, CTD phosphorylation, and histone deacetylases, coordinate the recruitment of Spt6 to transcribed genes in vivo. ..