Gene Symbol: RIM2
Alias: PYT1, Rim2p
Species: Saccharomyces cerevisiae S288c
Van Dyck E, Jank B, Ragnini A, Schweyen R, Duyckaerts C, Sluse F, et al
. Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria. Mol Gen Genet. 1995;246:426-36 pubmed
..This suppressor is a nuclear gene that was called RIM2/MRS12...
Li L, Murdock G, Bagley D, Jia X, Ward D, Kaplan J. Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transport. J Biol Chem. 2010;285:10232-42 pubmed publisher
..These results suggest that mitochondria-induced oxidant damage is responsible for activating Ccc1 and that Fra1 and Tsa1 can reduce oxidant damage. ..
Lin H, Li L, Jia X, Ward D, Kaplan J. Genetic and biochemical analysis of high iron toxicity in yeast: iron toxicity is due to the accumulation of cytosolic iron and occurs under both aerobic and anaerobic conditions. J Biol Chem. 2011;286:3851-62 pubmed publisher
..grown ?ccc1 cells encode organelle iron transporters including mitochondrial iron transporters MRS3, MRS4, and RIM2. Overexpression of MRS3 suppressed high iron toxicity by decreasing cytosolic iron through mitochondrial iron ..
Froschauer E, Rietzschel N, Hassler M, Binder M, Schweyen R, Lill R, et al
. The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron. Biochem J. 2013;455:57-65 pubmed publisher
..In Saccharomyces cerevisiae, overexpression of RIM2 (MRS12) encoding a mitochondrial pyrimidine nucleotide transporter can overcome the iron-related phenotypes of ..
Marobbio C, Di Noia M, Palmieri F. Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization. Biochem J. 2006;393:441-6 pubmed
..However, no protein has ever been found to be associated with this transport activity. In the present study, Rim2p has been identified as a yeast mitochondrial pyrimidine nucleotide transporter...
Yoon H, Zhang Y, Pain J, Lyver E, Lesuisse E, Pain D, et al
. Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria. Biochem J. 2011;440:137-46 pubmed publisher
..All such triple mutants were complemented by increased expression of Rim2, another mitochondrial carrier protein...