Gene Symbol: RIM11
Description: serine/threonine protein kinase RIM11
Alias: GSK3, MDS1, serine/threonine protein kinase RIM11
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Bowdish K, Yuan H, Mitchell A. Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1. Mol Cell Biol. 1994;14:7909-19 pubmed
    ..We report here the molecular characterization of the RIM11 gene, which we find is required for expression of several early meiotic genes...
  2. Yabuki Y, Kodama Y, Katayama M, Sakamoto A, Kanemaru H, Wan K, et al. Glycogen synthase kinase-3 is involved in regulation of ribosome biogenesis in yeast. Biosci Biotechnol Biochem. 2014;78:800-5 pubmed publisher
    ..Here, we found that Rrs1 interacts with two homologs of the glycogen synthase kinase-3 (GSK-3), Rim11, and Mrk1...
  3. Azab A, He Q, Ju S, Li G, Greenberg M. Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol. Mol Microbiol. 2007;63:1248-58 pubmed
    ..These results demonstrate for the first time that GSK-3 is required for optimal myo-inositol-3 phosphate synthase activity and de novo inositol biosynthesis, and that loss of GSK-3 activity causes inositol depletion. ..
  4. Wu C, Arcand M, Jansen G, Zhong M, Iouk T, Thomas D, et al. Phosphorylation of the MAPKKK regulator Ste50p in Saccharomyces cerevisiae: a casein kinase I phosphorylation site is required for proper mating function. Eukaryot Cell. 2003;2:949-61 pubmed
    ..However, this phosphorylation does not seem to have a detectable role in modulating the high-osmolarity glycerol synthesis pathway. ..
  5. Hirata Y, Andoh T, Asahara T, Kikuchi A. Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes. Mol Biol Cell. 2003;14:302-12 pubmed
    The yeast Saccharomyces cerevisiae has four genes, MCK1, MDS1 (RIM11), MRK1, and YOL128c, that encode homologues of mammalian glycogen synthase kinase 3 (GSK-3)...
  6. Andoh T, Hirata Y, Kikuchi A. PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. FEBS Lett. 2002;525:131-4 pubmed
    ..These results suggest that interaction of Rod1 and Rsp5 is important for drug resistance. ..
  7. Andoh T, Hirata Y, Kikuchi A. Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Mol Cell Biol. 2000;20:6712-20 pubmed
    The yeast Saccharomyces cerevisiae has four genes, MCK1, MDS1 (RIM11), MRK1, and YOL128c, that encode glycogen synthase kinase 3 (GSK-3) homologs...
  8. Puziss J, Hardy T, Johnson R, Roach P, Hieter P. MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3. Mol Cell Biol. 1994;14:831-9 pubmed
    ..Several unique classes of clones were identified, and one of these, designated MDS1, has been characterized in some detail...
  9. Zhan X, Hong Y, Zhu T, Mitchell A, Deschenes R, Guan K. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Mol Biol Cell. 2000;11:663-76 pubmed
    ..Mutation of MCK1 decreases sporulation efficiency, whereas mutation of RIM11, another GSK3 member, specifically abolishes sporulation; therefore, we investigated regulation of Rim11 by Tyr ..

More Information


  1. Malathi K, Xiao Y, Mitchell A. Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p. Mol Cell Biol. 1997;17:7230-6 pubmed
    ..Rim11p (also called Mds1p and ScGSK3) is a protein kinase related to glycogen synthase kinase 3 (GSK3); Ume6p is an architectural transcription factor; and Imelp is a Ume6p-binding protein that provides a ..
  2. Vidan S, Mitchell A. Stimulation of yeast meiotic gene expression by the glucose-repressible protein kinase Rim15p. Mol Cell Biol. 1997;17:2688-97 pubmed
    ..Glucose inhibits Ime1p-Ume6p interaction, and we find that Rim15p accumulation is repressed in glucose-grown cells. Thus, glucose repression of Rim15p may be responsible for glucose inhibition of Ime1p-Ume6p interaction. ..
  3. Rubin Bejerano I, Sagee S, Friedman O, Pnueli L, Kassir Y. The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11. Mol Cell Biol. 2004;24:6967-79 pubmed
    ..Similarly, the budding yeast homolog Rim11 is essential for the exit of diploid cells from the cell cycle and for entry into the meiotic developmental ..
  4. Kassir Y, Rubin Bejerano I, Mandel Gutfreund Y. The Saccharomyces cerevisiae GSK-3 beta homologs. Curr Drug Targets. 2006;7:1455-65 pubmed
    Yeast cells carry four homologs of GSK-3beta, RIM11, MCK1, MRK1 and YGK3. The significant homologs are RIM11 and MCK1 that presumably arose from a recent genome duplication followed by a rapid divergence...
  5. Kleineidam A, Vavassori S, Wang K, Schweizer L, Griac P, Schweizer M. Valproic acid- and lithium-sensitivity in prs mutants of Saccharomyces cerevisiae. Biochem Soc Trans. 2009;37:1115-20 pubmed publisher
    ..Yeast two-hybrid screening revealed that Prs3 and the yeast orthologue of GSK3 (glycogen synthase kinase 3), Rim11, a serine/threonine kinase involved in several signalling pathways, interact with each other...
  6. Mitchell A, Bowdish K. Selection for early meiotic mutants in yeast. Genetics. 1992;131:65-72 pubmed
    ..Suppressors of IME1 toxicity include recessive mutations in two genes, RIM11 and RIM16 (Regulator of Inducer of Meiosis), that are required for IME1 to activate IME2 expression...
  7. Drechsler H, Tan A, Liakopoulos D. Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2. J Cell Sci. 2015;128:3910-21 pubmed publisher
    ..We propose that yeast GSK-3 spatially controls astral MT dynamics and the loading of dynein and Kar9 on astral MT plus ends by regulating Kip2 interactions with Bim1 and MTs. ..
  8. Demin A, Lee M, Lee C, Seo Y. GSK-3? Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2. Genetics. 2017;206:829-842 pubmed publisher
    ..In this article, we identified Rim11, a GSK-3?-kinase homolog, as a multicopy suppressor of dna2 helicase-dead mutant (dna2-K1080E)...
  9. Malathi K, Xiao Y, Mitchell A. Catalytic roles of yeast GSK3beta/shaggy homolog Rim11p in meiotic activation. Genetics. 1999;153:1145-52 pubmed
    ..Therefore, Ime1p and Rim11p have two genetically separable functions in the sporulation program. However, catalytic activity of Rim11p is required for sporulation in the presence or absence of Ume6p. ..