Gene Symbol: RGC1
Description: Rgc1p
Alias: Rgc1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Paumi C, Menendez J, Arnoldo A, Engels K, Iyer K, Thaminy S, et al. Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis. Mol Cell. 2007;26:15-25 pubmed
    ..Our study provides proof of principle that iMYTH is an ideal methodology to identify physiological interactors and regulators of ABC transporters and other yeast transmembrane proteins...
  2. Lee J, Reiter W, Dohnal I, Gregori C, Beese Sims S, Kuchler K, et al. MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators. Genes Dev. 2013;27:2590-601 pubmed publisher
    ..Control of Fps1 channel activity in response to hyperosmotic shock involves a redundant pair of regulators, Rgc1 (regulator of the glycerol channel 1) and Rgc2, and the MAPK Hog1 (high-osmolarity glycerol response 1)...
  3. Wei W, Smith N, Wu X, Kim H, Seravalli J, Khalimonchuk O, et al. YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes. Antioxid Redox Signal. 2014;21:1475-89 pubmed publisher
  4. Lee J, Levin D. Rgc2 Regulator of Glycerol Channel Fps1 Functions as a Homo- and Heterodimer with Rgc1. Eukaryot Cell. 2015;14:719-25 pubmed publisher
    ..of its channel activity in response to hyperosmotic shock involves a redundant pair of fungus-specific regulators, Rgc1 and Rgc2 (regulators of the glycerol channel), and the mitogen-activatd protein kinase (MAPK) Hog1 (high-osmolarity ..
  5. Beese S, Negishi T, Levin D. Identification of positive regulators of the yeast fps1 glycerol channel. PLoS Genet. 2009;5:e1000738 pubmed publisher
    ..We describe the identification of a pair of positive regulators of the Fps1 glycerol channel, Rgc1 (Ypr115w) and Rgc2 (Ask10)...
  6. Beese Sims S, Lee J, Levin D. Yeast Fps1 glycerol facilitator functions as a homotetramer. Yeast. 2011;28:815-9 pubmed publisher
    ..Here we provide both genetic and biochemical evidence that Fps1 functions as a homotetramer to regulate glycerol transport in yeast. ..
  7. Ahmadpour D, Maciaszczyk Dziubinska E, Babazadeh R, Dahal S, Migocka M, Andersson M, et al. The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1. FEBS Lett. 2016;590:3649-3659 pubmed publisher
    ..We hypothesize that Hog1 and Slt2 may affect each other's binding to Fps1, thereby controlling the opening and closing of the channel. ..