REV1

Summary

Gene Symbol: REV1
Description: deoxycytidyl transferase
Alias: deoxycytidyl transferase
Species: Saccharomyces cerevisiae S288c
Products:     REV1

Top Publications

  1. Kuang L, Kou H, Xie Z, Zhou Y, Feng X, Wang L, et al. A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5. DNA Repair (Amst). 2013;12:27-37 pubmed publisher
    ..The Rev1 pathway constitutes the major mechanism of translesion synthesis and base damage-induced mutagenesis in model cell ..
  2. Acharya N, Johnson R, Pages V, Prakash L, Prakash S. Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase delta. Proc Natl Acad Sci U S A. 2009;106:9631-6 pubmed publisher
    ..interacts with Pol zeta or its associated proteins and provide evidence for the physical interaction of Pol32 with Rev1. Rev1 plays an indispensable structural role in Pol zeta-mediated TLS and it binds the Rev3 catalytic subunit of ..
  3. Wiltrout M, Walker G. Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1. DNA Repair (Amst). 2011;10:169-75 pubmed publisher
    ..Three TLS polymerases (Pols) function to bypass DNA damage in Saccharomyces cerevisiae: Rev1, Pol ?, a heterodimer of the Rev3 and Rev7 proteins, and Pol ? (Rad30). Our lab has shown that S...
  4. Daigaku Y, Davies A, Ulrich H. Ubiquitin-dependent DNA damage bypass is separable from genome replication. Nature. 2010;465:951-5 pubmed publisher
    ..Our approach has revealed the distribution of PRR tracts in a synchronized cell population. It will allow an in-depth mechanistic analysis of how cells manage the processing of lesions to their genomes during and after replication. ..
  5. Wood A, Garg P, Burgers P. A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage. J Biol Chem. 2007;282:20256-63 pubmed
    ..DNA damage bypass by the translesion synthesis polymerase Rev1 is enhanced by the presence of ubiquitinated PCNA...
  6. Otsuka C, Kunitomi N, Iwai S, Loakes D, Negishi K. Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo. Mutat Res. 2005;578:79-87 pubmed
    ..The effect of Poleta was also analyzed. From all the results DNA polymerases other than these two translesion polymerases, too, seem to initiate the translesion synthesis. ..
  7. D Souza S, Walker G. Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions. Mol Cell Biol. 2006;26:8173-82 pubmed
    The Saccharomyces cerevisiae REV3/7-encoded polymerase zeta and Rev1 are central to the replicative bypass of DNA lesions, a process called translesion synthesis (TLS)...
  8. Waters L, Walker G. The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase. Proc Natl Acad Sci U S A. 2006;103:8971-6 pubmed
    The Rev1 protein lies at the root of mutagenesis in eukaryotes...
  9. Nelson J, Lawrence C, Hinkle D. Deoxycytidyl transferase activity of yeast REV1 protein. Nature. 1996;382:729-31 pubmed
    ..We show here that Rev1 protein has a deoxycytidyl transferase activity which transfers a dCMP residue from dCTP to the 3' end of a DNA primer in a template-dependent ..

More Information

Publications72

  1. Gibbs P, McDonald J, Woodgate R, Lawrence C. The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer. Genetics. 2005;169:575-82 pubmed
    We have investigated the relative roles in vivo of Saccharomyces cerevisiae DNA polymerase eta, DNA polymerase zeta, Rev1 protein, and the DNA polymerase delta subunit, Pol32, in the bypass of an abasic site, T-T (6-4) photoadduct and T-T ..
  2. Acharya N, Johnson R, Prakash S, Prakash L. Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions. Mol Cell Biol. 2006;26:9555-63 pubmed
    b>Rev1, a Y family DNA polymerase (Pol) functions together with Polzeta, a B family Pol comprised of the Rev3 catalytic subunit and Rev7 accessory subunit, in promoting translesion DNA synthesis (TLS)...
  3. Acharya N, Haracska L, Johnson R, Unk I, Prakash S, Prakash L. Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain. Mol Cell Biol. 2005;25:9734-40 pubmed
    The Rev1 protein of Saccharomyces cerevisiae functions in translesion synthesis (TLS) together with DNA polymerase (Pol) zeta, which is comprised of the Rev3 catalytic and the Rev7 accessory subunits...
  4. McDonald J, Levine A, Woodgate R. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics. 1997;147:1557-68 pubmed
    ..cerevisiae REV1 genes, in UV resistance and UV-induced mutagenesis...
  5. Gallego Sánchez A, Andrés S, Conde F, San Segundo P, Bueno A. Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae. PLoS Genet. 2012;8:e1002826 pubmed publisher
    ..that deletion of UBP10 alters in different ways the interaction of PCNA with DNA polymerase ?-associated protein Rev1 and with accessory subunit Rev7...
  6. Pages V, Santa Maria S, Prakash L, Prakash S. Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast. Genes Dev. 2009;23:1438-49 pubmed publisher
    ..checkpoint proteins in nucleotide excision repair (NER)-proficient cells; however, in the absence of NER, checkpoint protein-mediated Rev1 phosphorylation contributes to increasing the proficiency of DNA polymerase zeta-dependent TLS.
  7. Wiltrout M, Walker G. The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant. Genetics. 2011;187:21-35 pubmed publisher
    ..The primary proteins mediating S. cerevisiae TLS are three DNA polymerases (Pols): Rev1, Pol ? (Rev3/7), and Pol ? (Rad30), all with human homologs...
  8. Ortiz Bazán M, Gallo Fernández M, Saugar I, Jiménez Martín A, Vázquez M, Tercero J. Rad5 plays a major role in the cellular response to DNA damage during chromosome replication. Cell Rep. 2014;9:460-8 pubmed publisher
    ..Thus, Rad5 ensures the completion of chromosome replication under DNA-damaging conditions while minimizing the risk of mutagenesis, thereby contributing significantly to genome integrity maintenance. ..
  9. Pages V, Bresson A, Acharya N, Prakash S, Fuchs R, Prakash L. Requirement of Rad5 for DNA polymerase zeta-dependent translesion synthesis in Saccharomyces cerevisiae. Genetics. 2008;180:73-82 pubmed publisher
    ..Rad5 action in this role is likely to be structural, since neither the inactivation of its ubiquitin ligase activity nor the inactivation of its helicase activity impairs its role in TLS. ..
  10. Ball L, Xu X, Blackwell S, Hanna M, Lambrecht A, Xiao W. The Rad5 helicase activity is dispensable for error-free DNA post-replication repair. DNA Repair (Amst). 2014;16:74-83 pubmed publisher
    ..Since the helicase domain overlaps with the SWI/SNF chromatin-remodelling domain, our findings suggest a structural role of this domain and that the Rad5 helicase activity is dispensable for error-free lesion bypass. ..
  11. Conde F, San Segundo P. Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1. Genetics. 2008;179:1197-210 pubmed publisher
    ..However, the rev1 dot1 and rev3 dot1 mutants show enhanced MMS sensitivity and dot1 does not attenuate the MMS sensitivity of rad52 ..
  12. Hirano Y, Sugimoto K. ATR homolog Mec1 controls association of DNA polymerase zeta-Rev1 complex with regions near a double-strand break. Curr Biol. 2006;16:586-90 pubmed
    ..Rev1 acts as a deoxycytidyl transferase, inserting dCMP opposite lesions...
  13. Lawrence C. Cellular functions of DNA polymerase zeta and Rev1 protein. Adv Protein Chem. 2004;69:167-203 pubmed
  14. Acharya N, Haracska L, Prakash S, Prakash L. Complex formation of yeast Rev1 with DNA polymerase eta. Mol Cell Biol. 2007;27:8401-8 pubmed
    In Saccharomyces cerevisiae, Rev1 functions in translesion DNA synthesis (TLS) together with polymerase zeta (Pol zeta), comprised of the Rev3 catalytic and Rev7 accessory subunits...
  15. Zhang H, Chatterjee A, Singh K. Saccharomyces cerevisiae polymerase zeta functions in mitochondria. Genetics. 2006;172:2683-8 pubmed
    ..measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase zeta and Rev1 proteins participate in the mitochondrial DNA mutagenesis...
  16. Sharma N, Kochenova O, Shcherbakova P. The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Pol?/Rev1-dependent translesion DNA synthesis. J Biol Chem. 2011;286:33557-66 pubmed publisher
    b>Rev1 and DNA polymerase ? (Pol?) are involved in the tolerance of DNA damage by translesion synthesis (TLS)...
  17. Lemontt J. Mutants of yeast defective in mutation induced by ultraviolet light. Genetics. 1971;68:21-33 pubmed
  18. Choi K, Batke S, Szakal B, Lowther J, Hao F, Sarangi P, et al. Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance. Nucleic Acids Res. 2015;43:2666-77 pubmed publisher
    ..These findings delineate how two Rad5 enzymatic domains concertedly influence PCNA modification, and unveil their discrete contributions to stress tolerance. ..
  19. Baynton K, Bresson Roy A, Fuchs R. Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae. Mol Microbiol. 1999;34:124-33 pubmed
    ..In the present study, strand segregation analysis is used to attempt to identify the role(s) of the Rev1 and Rev7 proteins during TLS...
  20. Gallego Sánchez A, Ufano S, Andrés S, Bueno A. Analysis of the tolerance to DNA alkylating damage in MEC1 and RAD53 checkpoint mutants of Saccharomyces cerevisiae. PLoS ONE. 2013;8:e81108 pubmed publisher
  21. Zhao B, Xie Z, Shen H, Wang Z. Role of DNA polymerase eta in the bypass of abasic sites in yeast cells. Nucleic Acids Res. 2004;32:3984-94 pubmed
    ..In cells lacking Poleta (rad30), Rev1, Polzeta (rev3), and both Poleta and Polzeta, translesion synthesis was reduced to 30%, 30%, 15% and 3% of the wild-..
  22. Siebler H, Lada A, Baranovskiy A, Tahirov T, Pavlov Y. A novel variant of DNA polymerase ?, Rev3?C, highlights differential regulation of Pol32 as a subunit of polymerase ? versus ? in Saccharomyces cerevisiae. DNA Repair (Amst). 2014;24:138-149 pubmed publisher
    ..The evidence for differential regulation of Pol32 in pol ? and pol ? emphasizes the complexity of polymerase switches. ..
  23. Becker J, Nguyen H, Wang X, Bielinsky A. Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair. Cell Cycle. 2014;13:1737-48 pubmed publisher
    ..Thus, it appears that DRIM is not proficient to fill replication gaps in pol1-1 and mcm10-1 mutants. Moreover, the ability to correctly prime nascent DNA may be a crucial prerequisite to initiate error-free PRR. ..
  24. Daraba A, Gali V, Halmai M, Haracska L, Unk I. Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae. PLoS Biol. 2014;12:e1001771 pubmed publisher
    ..We also show that purified Pol31 and Pol32 can form a complex with the TLS polymerase Rev1. Our results imply that TLS polymerases carry out DNA lesion bypass only after the Def1-assisted removal of Pol3 ..
  25. Pryor J, Gakhar L, Washington M. Structure and functional analysis of the BRCT domain of translesion synthesis DNA polymerase Rev1. Biochemistry. 2013;52:254-63 pubmed publisher
    ..The use of this pathway often results in somatic mutations that can drive carcinogenesis. Rev1 is a TLS polymerase found in all eukaryotes that plays a pivotal role in mediating DNA damage-induced mutagenesis...
  26. Ball L, Zhang K, Cobb J, Boone C, Xiao W. The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol. 2009;73:89-102 pubmed publisher
    ..This mechanism appears to be conserved throughout eukaryotes. ..
  27. Monti P, Ciribilli Y, Russo D, Bisio A, Perfumo C, Andreotti V, et al. Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent. DNA Repair (Amst). 2008;7:431-8 pubmed publisher
    ..contribution of translesion synthesis (TLS) DNA polymerases in the bypass of Me-lex-induced lesions, the REV3 and REV1 genes were independently deleted in the parental yeast strain and in different DNA repair-deficient derivatives: ..
  28. Boehm E, Powers K, Kondratick C, Spies M, Houtman J, Washington M. The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1. J Biol Chem. 2016;291:8735-44 pubmed publisher
    ..with the essential replication accessory protein proliferating cell nuclear antigen (PCNA) and the scaffold protein Rev1. In most Y-family polymerases, these interactions are mediated by one or more conserved PCNA-interacting protein (..
  29. Northam M, Moore E, Mertz T, Binz S, Stith C, Stepchenkova E, et al. DNA polymerases ? and Rev1 mediate error-prone bypass of non-B DNA structures. Nucleic Acids Res. 2014;42:290-306 pubmed publisher
    ..The Rev1 deoxycytidyl transferase can take over the stalled replicative polymerase and incorporate an additional 'C' at the hairpin base...
  30. Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, et al. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol. 2009;186:509-23 pubmed publisher
    ..associated with increased mitochondrial superoxide dismutase (MnSOD) expression, decreased DNA oxidation, reduced REV1 expression and translesion synthesis, and elevated resistance to oxidative stress-induced mutagenesis...
  31. Dittmar J, Pierce S, Rothstein R, Reid R. Physical and genetic-interaction density reveals functional organization and informs significance cutoffs in genome-wide screens. Proc Natl Acad Sci U S A. 2013;110:7389-94 pubmed publisher
    ..Furthermore, because CLIK uses previously annotated interaction data to determine biologically informed cutoffs, it provides additional insights into screen results, which supplement traditional statistical approaches. ..
  32. Saugar I, Parker J, Zhao S, Ulrich H. The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA. Nucleic Acids Res. 2012;40:245-57 pubmed publisher
    ..Our identification of Mgs1 as a UBZ-dependent downstream effector of ubiquitylated PCNA suggests an explanation for the ambivalent role of the protein in damage processing. ..
  33. Gritenaite D, Princz L, Szakal B, Bantele S, Wendeler L, Schilbach S, et al. A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication. Genes Dev. 2014;28:1604-19 pubmed publisher
    ..Thus, Dpb11-Slx4 integrates several cellular inputs and participates in the temporal program for activation of the JM-resolving nuclease Mus81. ..
  34. Kim N, Jinks Robertson S. dUTP incorporation into genomic DNA is linked to transcription in yeast. Nature. 2009;459:1150-3 pubmed publisher
    ..These results show an unexpected relationship between transcription and the fidelity of DNA synthesis, and raise intriguing cell biological issues with regard to nucleotide pool compartmentalization. ..
  35. Kochenova O, Bezalel Buch R, Tran P, Makarova A, Chabes A, Burgers P, et al. Yeast DNA polymerase ? maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations. Nucleic Acids Res. 2017;45:1200-1218 pubmed publisher
    ..dNTP pools increase for Pol? function, we studied the activity and fidelity of four-subunit Pol? (Pol?4) and Pol?4-Rev1 (Pol?5) complexes in vitro at ‘normal S-phase’ and ‘damage-response’ dNTP concentrations...
  36. Karras G, Fumasoni M, Sienski G, Vanoli F, Branzei D, Jentsch S. Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell. 2013;49:536-46 pubmed publisher
    ..Our findings thus reveal unexpected cooperation in the error-free pathway between the two related clamps and indicate that 9-1-1 plays a broader role in the DNA damage response than previously assumed. ..
  37. Ang J, Duffy S, Segovia R, Stirling P, Hieter P. Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase. Genetics. 2016;204:975-986 pubmed publisher
    ..We believe this represents a novel mutator mode-of-action and opens up new prospects to understand how upregulation of DNA repair proteins may contribute to mutagenesis. ..
  38. Bomar M, D Souza S, Bienko M, Dikic I, Walker G, Zhou P. Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. Mol Cell. 2010;37:408-17 pubmed publisher
    ..The accumulation of Y family polymerases (pol) iota and Rev1 at the stalled replication machinery is mediated by the ubiquitin-binding motifs (UBMs) of the polymerases and ..
  39. Nair D, Johnson R, Prakash L, Prakash S, Aggarwal A. DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase. J Mol Biol. 2011;406:18-28 pubmed publisher
    ..b>Rev1, a member of Y-family DNA polymerases, does not obey the A-rule...
  40. Martini E, Keeney S, Osley M. A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. Genetics. 2002;160:1375-87 pubmed
    ..When combined with a ubc13Delta mutation, which is also epistatic with rad5Delta, the htb1-3 mutation enhanced UV-induced cell killing. These results suggest that histone H2B acts in a novel RAD5-dependent branch of PRR. ..
  41. Guo D, Xie Z, Shen H, Zhao B, Wang Z. Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein. Nucleic Acids Res. 2004;32:1122-30 pubmed
    ..zeta (Polzeta) mutagenesis pathway is a major error-prone translesion synthesis mechanism requiring Polzeta and Rev1. In addition to its dCMP transferase, a non-catalytic function of Rev1 is suspected in cellular response to certain ..
  42. Arbel Eden A, Joseph Strauss D, Masika H, Printzental O, Rachi E, Simchen G. Trans-Lesion DNA Polymerases May Be Involved in Yeast Meiosis. G3 (Bethesda). 2013;3:633-644 pubmed publisher
    ..We find that the three TLSPs of budding yeast Saccharomyces cerevisiae Rev1, PolZeta (Rev3 and Rev7), and Rad30 are induced during meiosis at a time when DNA double-strand breaks (DSBs) are ..
  43. Lévesque N, Leung G, Fok A, Schmidt T, Kobor M. Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway. J Biol Chem. 2010;285:35113-22 pubmed publisher
    ..These data revealed a multifaceted functional relationship between Rtt107 and Dot1 in the DNA damage response and maintenance of genome integrity. ..
  44. Pustovalova Y, Maciejewski M, Korzhnev D. NMR mapping of PCNA interaction with translesion synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain. J Mol Biol. 2013;425:3091-105 pubmed publisher
    b>Rev1 is a Y-family translesion synthesis (TLS) DNA polymerase involved in bypass replication across sites of DNA damage and postreplicational gap filling...
  45. Harkins V, Gabrielse C, Haste L, Weinreich M. Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains. Genetics. 2009;183:1269-82 pubmed publisher
    ..Dbf4 proteins that contain known BRCT domains in Saccharomyces cerevisiae, we show that the BRCT domain from Rev1, a translesion DNA polymerase, can uniquely substitute for the Dbf4 BRCT domain...
  46. Sakofsky C, Ayyar S, Deem A, Chung W, Ira G, Malkova A. Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements. Mol Cell. 2015;60:860-72 pubmed publisher
    ..template switches, indicative of MMBIR, are driven by translesion synthesis (TLS) polymerases Polζ and Rev1. Thus, an interruption of BIR involving fully homologous chromosomes in yeast triggers a switch to MMBIR catalyzed ..
  47. Masuda Y, Kamiya K. [Induced mutagenesis and translesion DNA synthesis--structure and function of REV1]. Seikagaku. 2008;80:843-6 pubmed
  48. D Souza S, Waters L, Walker G. Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance. DNA Repair (Amst). 2008;7:1455-70 pubmed publisher
    The genes encoding Rev1 and DNA polymerase zeta (Rev3/Rev7) are together required for the vast majority of DNA damage-induced mutations in eukaryotes from yeast to humans...
  49. Rechkoblit O, Kolbanovskiy A, Landes H, Geacintov N, Aggarwal A. Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase. Nat Commun. 2017;8:965 pubmed publisher
    ..b>Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed mechanism of DNA ..
  50. Mito E, Mokhnatkin J, Steele M, Buettner V, Sommer S, Manthey G, et al. Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae. Genetics. 2008;179:1795-806 pubmed publisher
    ..The translesion polymerases Pol eta, Pol zeta, and Rev1 are part of a suite of factors in yeast that can act at sites of replicative polymerase failure...
  51. Howell C, Prakash S, Washington M. Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 protein. Biochemistry. 2007;46:13451-9 pubmed
    The yeast Rev1 protein (Rev1p) is a member of the Y family of DNA polymerases that specifically catalyzes the incorporation of C opposite template G and several types of DNA damage...
  52. Bostelman L, Keller A, Albrecht A, Arat A, Thompson J. Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae. DNA Repair (Amst). 2007;6:383-95 pubmed
    ..The overall results indicate the existence of distinct and separable roles of histone H3 lysine-79 methylation in the response to UV damage, potentially serving to coordinate the various repair processes. ..
  53. Nair D, Johnson R, Prakash L, Prakash S, Aggarwal A. Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science. 2005;309:2219-22 pubmed
    The Rev1 DNA polymerase is highly specialized for the incorporation of C opposite template G...
  54. Baruffini E, Serafini F, Ferrero I, Lodi T. Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caused by pathological mutations in DNA polymerase gamma in yeast. PLoS ONE. 2012;7:e34322 pubmed publisher
    In yeast, DNA polymerase zeta (Rev3 and Rev7) and Rev1, involved in the error-prone translesion synthesis during replication of nuclear DNA, localize also in mitochondria...
  55. Qin Z, Lu M, Xu X, Hanna M, Shiomi N, Xiao W. DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Pol?. Nucleic Acids Res. 2013;41:7356-69 pubmed publisher
    ..In contrast, depletion of Rev1, another TLS polymerase serving as a scaffold for the assembly of the TLS complex, completely abolished PCNA•Ub-..
  56. Giannattasio M, Follonier C, Tourrière H, Puddu F, Lazzaro F, Pasero P, et al. Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation. Mol Cell. 2010;40:50-62 pubmed publisher
    ..Our work has significant implications for understanding the coordination between repair of DNA lesions and checkpoint pathways to preserve genome stability. ..
  57. Arakawa H, Moldovan G, Saribasak H, Saribasak N, Jentsch S, Buerstedde J. A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol. 2006;4:e366 pubmed
    ..This is the first evidence, to our knowledge, that vertebrates exploit the PCNA-ubiquitin pathway for immunoglobulin hypermutation, most likely through the recruitment of error-prone DNA polymerases. ..
  58. Yang Y, Sterling J, Storici F, Resnick M, Gordenin D. Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet. 2008;4:e1000264 pubmed publisher
    ..Hypermutability and multiple mutations associated with lesions in transient stretches of long single-strand DNA may be a source of carcinogenesis and provide selective advantage in adaptive evolution. ..
  59. Xu X, Lin A, Zhou C, Blackwell S, Zhang Y, Wang Z, et al. Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res. 2016;44:5231-45 pubmed publisher
    ..Rad5 is a multi-functional protein and may also play a role in TLS, since it interacts with the TLS polymerase Rev1. In this study we mapped the Rev1-interaction domain in Rad5 to the amino acid resolution and demonstrated that ..
  60. Boehm E, Spies M, Washington M. PCNA tool belts and polymerase bridges form during translesion synthesis. Nucleic Acids Res. 2016;44:8250-60 pubmed publisher
    ..the ternary complexes containing proliferating cell nuclear antigen (PCNA) and two non-classical DNA polymerases, Rev1 and DNA polymerase η, have two architectures: PCNA tool belts and Rev1 bridges...
  61. Halmai M, Frittmann O, Szabo Z, Daraba A, Gali V, Balint E, et al. Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain. PLoS ONE. 2016;11:e0161307 pubmed publisher
  62. Lazzaro F, Novarina D, Amara F, Watt D, Stone J, Costanzo V, et al. RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNA. Mol Cell. 2012;45:99-110 pubmed publisher
  63. Schürer K, Rudolph C, Ulrich H, Kramer W. Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. Genetics. 2004;166:1673-86 pubmed
    ..The dependence of the mph1 mutator phenotype on REV3 and REV1 and the synergy with mutations in base and nucleotide excision repair suggest an involvement of MPH1 in error-free ..