RET2

Summary

Gene Symbol: RET2
Description: coatomer subunit delta
Alias: coatomer subunit delta
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, et al. Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex. J Cell Biol. 1996;135:53-61 pubmed
    ..We propose that these interactions reflect in vivo associations of those subunits and thus play a functional role in the assembly of coatomer and/or serve to maintain the molecular architecture of the complex. ..
  2. Eugster A, Frigerio G, Dale M, Duden R. COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. EMBO J. 2000;19:3905-17 pubmed
    ..Glo3p also interacts with intact coatomer in vitro. ..
  3. Reilly B, Kraynack B, VanRheenen S, Waters M. Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit. Mol Biol Cell. 2001;12:3783-96 pubmed
    ..Last, we show that Dsl1p interacts with the delta-subunit of the retrograde COPI coat, Ret2p, and discuss possible roles for this interaction. ..
  4. Yu X, Breitman M, Goldberg J. A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes. Cell. 2012;148:530-42 pubmed publisher
    ..A bivalent GTP-dependent binding mode has implications for the dynamics of coatomer interaction with the Golgi and for the selection of cargo molecules. ..
  5. Jarmoszewicz K, Łukasiak K, Riezman H, Kaminska J. Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants. PLoS ONE. 2012;7:e39582 pubmed publisher
    ..Additionally, Rsp5 and Sla1 proteins were found by co-immunoprecipitation in a complex containing COPI subunits. Together, our results show that Rsp5 ligase plays a role in regulating retrograde Golgi-to-ER trafficking. ..
  6. Cosson P, Démollière C, Hennecke S, Duden R, Letourneur F. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. EMBO J. 1996;15:1792-8 pubmed
    ..While both ret2-1 and ret3-1 were defective for ER retrieval, only ret2-1 exhibited a defect in forward ER-to-Golgi transport at ..
  7. Frigerio G. The Saccharomyces cerevisiae early secretion mutant tip20 is synthetic lethal with mutants in yeast coatomer and the SNARE proteins Sec22p and Ufe1p. Yeast. 1998;14:633-46 pubmed
    ..temperature-sensitive tip20 mutants are shown to be lethal in combination with ufe1-1, a target SNARE of the ER and ret2-1, yeast delta-COP...
  8. Rein U, Andag U, Duden R, Schmitt H, Spang A. ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat. J Cell Biol. 2002;157:395-404 pubmed
    ..The mechanisms by which v-SNAREs interact with COPI and COPII coat proteins seem to be different and may play a key role in determining specificity in vesicle budding...
  9. Michelsen K, Schmid V, Metz J, Heusser K, Liebel U, Schwede T, et al. Novel cargo-binding site in the beta and delta subunits of coatomer. J Cell Biol. 2007;179:209-17 pubmed
    ..A homology model of the COPI trunk domain illustrates the recognition of R-based signals by COPI. ..

More Information

Publications16

  1. Tu L, Tai W, Chen L, Banfield D. Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science. 2008;321:404-7 pubmed publisher
    ..We propose that Vps74p maintains the steady-state localization of Golgi glycosyltransferases dynamically, by promoting their incorporation into COPI-coated vesicles. ..
  2. Yip C, Walz T. Molecular structure and flexibility of the yeast coatomer as revealed by electron microscopy. J Mol Biol. 2011;408:825-31 pubmed publisher
    ..Our analyses provide the first three-dimensional picture of the complete coatomer and reveal substantial conformational flexibility likely to be critical for its scaffolding function. ..
  3. Hirata R, Nihei C, Nakano A. Isoform-selective oligomer formation of Saccharomyces cerevisiae p24 family proteins. J Biol Chem. 2013;288:37057-70 pubmed publisher
    ..This complex was mainly localized to the Golgi, whereas the p24 complex containing Erv25, instead of Rrt6 but otherwise with the same isoform composition, was found mostly in the ER...
  4. Kim D, Massey T, Sacher M, Pypaert M, Ferro Novick S. Sgf1p, a new component of the Sec34p/Sec35p complex. Traffic. 2001;2:820-30 pubmed
    ..Although an earlier study suggested that Sec34p (Grd20p) is not required for protein secretion, we show here that the sec34-2 and sec35-1 mutations lead to a pleiotropic block in the secretion of all proteins into the growth medium. ..
  5. Andag U, Schmitt H. Dsl1p, an essential component of the Golgi-endoplasmic reticulum retrieval system in yeast, uses the same sequence motif to interact with different subunits of the COPI vesicle coat. J Biol Chem. 2003;278:51722-34 pubmed
    ..They interact with different layers of the vesicle coat by using tandemly arranged sequence motifs, some of which have dual specificity. ..
  6. Arai S, Noda Y, Kainuma S, Wada I, Yoda K. Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the coatomer subunit Ret2. Curr Biol. 2008;18:987-91 pubmed publisher
    ..Here, we report that Ypt11, a Rab GTPase that reportedly interacts with Myo2, binds to Ret2, a subunit of the coatomer complex...
  7. Suckling R, Poon P, Travis S, Majoul I, Hughson F, Evans P, et al. Structural basis for the binding of tryptophan-based motifs by δ-COP. Proc Natl Acad Sci U S A. 2015;112:14242-7 pubmed publisher