RED1

Summary

Gene Symbol: RED1
Description: Red1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins
    J M Bailis
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Mol Cell Biol 20:4838-48. 2000
  2. ncbi Expression and DNA sequence of RED1, a gene required for meiosis I chromosome segregation in yeast
    E A Thompson
    Department of Biology, Yale University, New Haven, CT 06511 8112
    Mol Gen Genet 218:293-301. 1989
  3. pmc Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1
    Hengyao Niu
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 16:5804-18. 2005
  4. pmc Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes
    A Storlazzi
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:9043-8. 1996
  5. ncbi Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation
    Yuval Blat
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 111:791-802. 2002
  6. pmc A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae
    T de los Santos
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 159:1511-25. 2001
  7. pmc Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast
    Lihong Wan
    Institute for Cell and Developmental Biology, Department of Biochemistry and Cell Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    Mol Biol Cell 15:11-23. 2004
  8. ncbi Mnd1 is required for meiotic interhomolog repair
    Christian Zierhut
    Max F Perutz Laboratories, Cell Biology and Genetics, Institute of Botany, University of Vienna, Rennweg 14, A 1030, Vienna, Austria
    Curr Biol 14:752-62. 2004
  9. pmc Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p
    D Woltering
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 20:6646-58. 2000
  10. pmc SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae
    Chung Hsu Cheng
    Institute of Biochemical Science, National Taiwan University, Taipei
    Genes Dev 20:2067-81. 2006

Scientific Experts

  • Katrina F Cooper
  • Feng Ming Lin
  • Yi Ju Lai
  • Lihong Wan
  • Ting Fang Wang
  • J M Bailis
  • N M Hollingsworth
  • T de los Santos
  • Nancy M Hollingsworth
  • Hui Ju Shen
  • Christian S Eichinger
  • G S Roeder
  • G Valentin Börner
  • Hiromichi Kosaka
  • Hsiao Chi Lo
  • Chung Hsu Cheng
  • Akira Shinohara
  • Hideo Tsubouchi
  • Nancy Kleckner
  • Hengyao Niu
  • Christian Zierhut
  • Yuval Blat
  • A V Smith
  • Mei Jen Chuang
  • J Loidl
  • B Larkin
  • Stefan Jentsch
  • G M Venturi
  • A Miyajima
  • Yun Hsin Cheng
  • D Woltering
  • L Xu
  • L J García-Rodriguez
  • Aekam Barot
  • Bruce Futcher
  • Adam Rosebrock
  • Miki Shinohara
  • G Shirleen Roeder
  • Yu Hui Lo
  • Han Yi Huang
  • Shu Shan Liang
  • Shih Chieh Ti
  • Chia Hui Yeh
  • Josef Loidl
  • Bridget Baumgartner
  • Dana Schaefer
  • Franz Klein
  • Teresa de Los Santos
  • Kevan Shokat
  • Marc Berlinger
  • Christian Rupp
  • Chao Zhang
  • N Kleckner
  • J Tu
  • A Storlazzi
  • Reine U Protacio
  • Neil Hunter
  • K Ohta
  • T Williams-Hart
  • N Odagiri
  • A Duran
  • Y Kikuchi
  • M Seki
  • A Bloecher
  • T Enomoto
  • Y Ohno
  • M Shiratori
  • B Baumgartner
  • S Bagchi
  • K Tatchell
  • C Roncero
  • F Onoda
  • D B Friedman
  • B M Weiner
  • L Ponte
  • W Song
  • A Schwacha
  • M Carlson
  • B Byers
  • A D Johnson
  • B Rockmill
  • E A Thompson

Detail Information

Publications31

  1. pmc Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins
    J M Bailis
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Mol Cell Biol 20:4838-48. 2000
    ..Overproduction of either the meiotic chromosomal protein Red1 or the meiotic kinase Mek1 bypasses this checkpoint, allowing zip1 cells to sporulate...
  2. ncbi Expression and DNA sequence of RED1, a gene required for meiosis I chromosome segregation in yeast
    E A Thompson
    Department of Biology, Yale University, New Haven, CT 06511 8112
    Mol Gen Genet 218:293-301. 1989
    Genetic studies have previously demonstrated that the RED1 gene of Saccharomyces cerevisiae is required for chromosome segregation at the first meiotic division...
  3. pmc Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1
    Hengyao Niu
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 16:5804-18. 2005
    ..created by the meiosis-specific kinase, Mek1, in a complex with two other meiosis-specific proteins, Hop1 and Red1. HOP1 contains two functional domains, called the N and C domains...
  4. pmc Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes
    A Storlazzi
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:9043-8. 1996
    ..Also, Holliday junctions are present at unusually late times, presumably as precursors to late-appearing products. Red1 is an axial structure component required for formation of cytologically discernible axial elements and SC and ..
  5. ncbi Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation
    Yuval Blat
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 111:791-802. 2002
    ..Meiotic chromosomal protein, Red1, localizes to chromosome axes; however, Red1 loading is modulated by R/G-bands isochores and thus by bulk chromatin ..
  6. pmc A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae
    T de los Santos
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 159:1511-25. 2001
    ..In spo13 diploids, red1, but not mek1, is epistatic to mms4 for sporulation and spore viability, suggesting that MMS4 may be required only ..
  7. pmc Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast
    Lihong Wan
    Institute for Cell and Developmental Biology, Department of Biochemistry and Cell Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    Mol Biol Cell 15:11-23. 2004
    Three meiosis-specific chromosomal components in budding yeast, Mek1, Red1, and Hop1, are required for recombination, proper segregation of homologs, and the meiotic recombination checkpoint. Mek1 is a protein kinase...
  8. ncbi Mnd1 is required for meiotic interhomolog repair
    Christian Zierhut
    Max F Perutz Laboratories, Cell Biology and Genetics, Institute of Botany, University of Vienna, Rennweg 14, A 1030, Vienna, Austria
    Curr Biol 14:752-62. 2004
    ..Thus, during meiosis, it is the homologous chromosome rather than the sister chromatid that is used as a repair template...
  9. pmc Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p
    D Woltering
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 20:6646-58. 2000
    In yeast, HOP1 and RED1 are required during meiosis for proper chromosome segregation and the consequent formation of viable spores...
  10. pmc SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae
    Chung Hsu Cheng
    Institute of Biochemical Science, National Taiwan University, Taipei
    Genes Dev 20:2067-81. 2006
    ..At and after mid-prophase, the Zip1 protein begins to associate with Zip3-dependent Smt3 conjugates (e.g., Red1) along meiotic chromosomes in the wild-type cell to form SCs and with Smt3 polymeric chains in the zip3 mutant to ..
  11. ncbi Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast
    T de los Santos
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, SUNY Stony Brook, Stony Brook, New York 11794 5215, USA
    J Biol Chem 274:1783-90. 1999
    ..cerevisiae, HOP1 and RED1, is critical for proper assembly and function of the SC...
  12. pmc Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein
    J M Bailis
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103 USA
    Genes Dev 12:3551-63. 1998
    ..The Mek1 protein associates with meiotic chromosomes and colocalizes with the Red1 protein, which is a component of meiotic chromosome cores...
  13. pmc The yeast Red1 protein localizes to the cores of meiotic chromosomes
    A V Smith
    Department of Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    J Cell Biol 136:957-67. 1997
    Mutants in the meiosis-specific RED1 gene of S. cerevisiae fail to make any synaptonemal complex (SC) or any obvious precursors to the SC...
  14. pmc Genetic interactions between HOP1, RED1 and MEK1 suggest that MEK1 regulates assembly of axial element components during meiosis in the yeast Saccharomyces cerevisiae
    N M Hollingsworth
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215, USA
    Genetics 147:33-42. 1997
    ..Genetic and cytological data suggest that three meiosis-specific genes, HOP1, RED1 and MEK1, are involved in axial element formation in the yeast Saccharomyces cerevisiae...
  15. ncbi Pachytene exit controlled by reversal of Mek1-dependent phosphorylation
    J M Bailis
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell 101:211-21. 2000
    ..This pachytene checkpoint requires two meiotic chromosomal proteins, Red1 and Mek1; Mek1 is a kinase that phosphorylates Red1...
  16. pmc RED1: a yeast gene required for the segregation of chromosomes during the reductional division of meiosis
    B Rockmill
    Department of Biology, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 85:6057-61. 1988
    A mutation at the RED1 locus was identified in a search for sporulation-proficient, meiotic-lethal yeast mutants...
  17. pmc Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis
    D B Friedman
    Department of Genetics, University of Washington, Seattle 98195
    Genetics 136:449-64. 1994
    ..On the other hand, suppression by overexpression of RED1 from a 2 mu plasmid was found only for allele hop1-628ts...
  18. pmc A conditional allele of the Saccharomyces cerevisiae HOP1 gene is suppressed by overexpression of two other meiosis-specific genes: RED1 and REC104
    N M Hollingsworth
    Department of Microbiology, University of California, San Francisco 94143 0502
    Genetics 133:785-97. 1993
    ..The DNA sequence of one high copy suppressor gene matched that of RED1, a previously identified meiosis-specific gene...
  19. pmc Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1
    Christian S Eichinger
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 107:11370-5. 2010
    ..Here, we identify the SC protein Red1 as a crucial regulator of early meiosis...
  20. pmc Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis
    Feng Ming Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    EMBO J 29:586-96. 2010
    ..Here, we report that, like the CE component Zip1, Saccharomyces cerevisiae axial-element structural protein, Red1, can bind small ubiquitin-like modifier (SUMO) polymeric chains...
  21. pmc Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis
    G Valentin Börner
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:3327-32. 2008
    We show that, during budding yeast meiosis, axis ensemble Hop1/Red1 and synaptonemal complex (SC) component Zip1 tend to occur in alternating strongly staining domains...
  22. pmc Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis
    Hsiao Chi Lo
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Mol Biol Cell 19:4956-67. 2008
    ..The use of the same kinase to regulate several distinct meiosis-specific processes may be important for the coordination of these processes during meiosis...
  23. pmc Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination
    Hiromichi Kosaka
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka, Japan
    PLoS Genet 4:e1000196. 2008
    ..We propose that chromosome movement and associated telomere dynamics at the nuclear envelope promotes the completion of key biochemical steps during meiotic recombination...
  24. pmc Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae
    Katrina F Cooper
    Department of Biochemistry, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Genetics 181:65-79. 2009
    ..This role is meiosis specific as Mcd1p destruction is not altered in vegetative pds1Delta cultures. These results define a previously undescribed role for Pds1p in cohesin maintenance, recombination, and meiotic progression...
  25. pmc Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired
    Hideo Tsubouchi
    Department of Molecular, Cellular, and Developmental Biology, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 20:1766-75. 2006
    ..We propose that Hed1 provides a mechanism to ensure the coordinated action of Rad51 and Dmc1 during meiosis, by down-regulating Rad51 activity when Dmc1 is unavailable...
  26. pmc Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions
    A Miyajima
    Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Mol Cell Biol 20:6399-409. 2000
    ..Disruption of the RED1 or RAD17 gene partially alleviated the poor-sporulation phenotype of sgs1 disruptants, indicating that portions of ..
  27. pmc Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae
    G M Venturi
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport, Louisiana 71130, USA
    Genetics 155:69-83. 2000
    ..Together our data suggest that Ppz1p and Ppz2p may have overlapping functions with Glc7p and that all three phosphatases may act through common regulatory proteins...
  28. pmc Calcofluor antifungal action depends on chitin and a functional high-osmolarity glycerol response (HOG) pathway: evidence for a physiological role of the Saccharomyces cerevisiae HOG pathway under noninducing conditions
    L J García-Rodriguez
    Instituto de Microbiologia Bioquimica, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, 37007 Salamanca, Spain
    J Bacteriol 182:2428-37. 2000
    ....
  29. ncbi Meiotic cells monitor the status of the interhomolog recombination complex
    L Xu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 11:106-18. 1997
    ..We report here the effects of mutations in two other (meiosis-specific) genes, RED1 and MEK1/MRE4, that encode a chromosome structure component and a protein kinase, respectively...
  30. pmc Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae
    J Tu
    Integrated Program in Cellular Biology, Molecular Biology and Biophysics Studies, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 16:4199-206. 1996
    ..Finally, we recovered two genes, RED1 and SCD5, with roles in meiosis and the vesicular secretory pathway, respectively...
  31. pmc Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1
    Yi Ju Lai
    Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Taipei 115, Taiwan
    Mol Cell Biol 31:912-23. 2011
    ..Lateral elements also are called axial elements prior to synapsis. In Saccharomyces cerevisiae, Red1, Hop1, and Mek1 are structural components of axial/lateral elements...