Gene Symbol: REC8
Description: Rec8p
Alias: SPO69, Rec8p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Callender T, Hollingsworth N. Mek1 suppression of meiotic double-strand break repair is specific to sister chromatids, chromosome autonomous and independent of Rec8 cohesin complexes. Genetics. 2010;185:771-82 pubmed publisher
    ..b>Rec8 cohesin complexes are not required, however, either for suppression of intersister DSB repair or for the repair ..
  2. Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, et al. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Cell. 2005;120:773-88 pubmed
    ..In vitro, Mnd2 inhibits ubiquitination of Pds1 by APC/C-Ama1 but not by other APC/C holo-enzymes. We conclude that chromosome segregation in meiosis depends on the selective inhibition of a meiosis-specific form of the APC/C. ..
  3. Yu H, Koshland D. Chromosome morphogenesis: condensin-dependent cohesin removal during meiosis. Cell. 2005;123:397-407 pubmed
  4. Klein F, Mahr P, Galova M, Buonomo S, Michaelis C, Nairz K, et al. A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell. 1999;98:91-103 pubmed
    ..We show here that Smc3p and a meiotic version of Scc1p called Rec8p are required for cohesion between sister chromatids, for formation of axial elements, for reciprocal recombination,..
  5. Lee B, Amon A. Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation. Science. 2003;300:482-6 pubmed
    ..Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5. ..
  6. Penkner A, Prinz S, Ferscha S, Klein F. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Cell. 2005;120:789-801 pubmed
    Meiotic cohesin serves in sister chromatid linkage and DNA repair until its subunit Rec8 is cleaved by separase...
  7. Kiburz B, Reynolds D, Megee P, Marston A, Lee B, Lee T, et al. The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes Dev. 2005;19:3017-30 pubmed
    ..Our results identify the portions of chromosomes where cohesins are protected from removal during meiosis I and show that kinetochore components and cohesins themselves are required to establish this cohesin protective domain. ..
  8. Petronczki M, Matos J, Mori S, Gregan J, Bogdanova A, Schwickart M, et al. Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Cell. 2006;126:1049-64 pubmed
  9. Hong S, Choi E, Kim K. Ycs4 is Required for Efficient Double-Strand Break Formation and Homologous Recombination During Meiosis. J Microbiol Biotechnol. 2015;25:1026-35 pubmed publisher
    ..ycs4S relieved the defects in the progression of recombination interactions induced as a result of the absence of Rec8. These results suggest that condensin is a crucial coordinator of the recombination process and chromosome ..

More Information


  1. Lin W, Wang M, Jin H, Yu H. Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae. Genetics. 2011;187:1041-51 pubmed publisher that the cohesin subunits Scc3 and Smc1 are both required for the production of the meiosis-specific subunit Rec8 in the budding yeast Saccharomyces cerevisiae...
  2. Brar G, Hochwagen A, Ee L, Amon A. The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing. Mol Biol Cell. 2009;20:1030-47 pubmed publisher
    ..Using mutants in the cohesin subunit Rec8, in which phosphorylated residues were mutated to alanines, we show that cohesin phosphorylation is not only ..
  3. Yoon S, Lee M, Xaver M, Zhang L, Hong S, Kong Y, et al. Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure. Nucleic Acids Res. 2016;44:9296-9314 pubmed
    b>Rec8 is a prominent component of the meiotic prophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and chromosome synapsis. Here, we explore the prophase roles of Rec8...
  4. Bizzari F, Marston A. Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol. 2011;193:1213-28 pubmed publisher
    ..Therefore, Cdc55 orders passage through the meiotic divisions by ensuring a balance of phosphatases. ..
  5. Zierhut C, Berlinger M, Rupp C, Shinohara A, Klein F. Mnd1 is required for meiotic interhomolog repair. Curr Biol. 2004;14:752-62 pubmed
    ..The presence of Rec8, Red1, or Hop1 renders Mnd1 indispensable for DNA repair, presumably through the establishment of interhomolog (IH) ..
  6. Cha R, Weiner B, Keeney S, Dekker J, Kleckner N. Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p. Genes Dev. 2000;14:493-503 pubmed
    ..Deletion of the SPO11 gene decreases the length of S phase by approximately 25%. Rec8p is a key coordinator of meiotic interhomolog and intersister interactions...
  7. Chuong H, Dawson D. Meiotic cohesin promotes pairing of nonhomologous centromeres in early meiotic prophase. Mol Biol Cell. 2010;21:1799-809 pubmed publisher
    ..However, the meiotic cohesin Rec8p is required for centromere coupling...
  8. Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, et al. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Mol Biol Cell. 2009;20:3064-76 pubmed publisher
    ..The meiotic cohesin Rec8 has been implicated in regulating DSB formation, but little is known about the features of their interplay...
  9. Sommermeyer V, BĂ©neut C, Chaplais E, Serrentino M, Borde V. Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes. Mol Cell. 2013;49:43-54 pubmed publisher
    ..This paper provides the molecular mechanism linking DSB sequences to chromosome axes and explains why H3K4 methylation is important for meiotic recombination. ..
  10. Gruber S, Haering C, Nasmyth K. Chromosomal cohesin forms a ring. Cell. 2003;112:765-77 pubmed
    ..Cleavage of the Smc3 coiled coil is sufficient to trigger cohesin release from chromosomes and loss of sister cohesion, consistent with a topological association with chromatin. ..
  11. Sun X, Huang L, Markowitz T, Blitzblau H, Chen D, Klein F, et al. Transcription dynamically patterns the meiotic chromosome-axis interface. elife. 2015;4: pubmed publisher
    ..We propose that such robust but flexible tethering allows the axial element to promote recombination while easily adapting to changes in chromosome activity. ..
  12. Katis V, Lipp J, Imre R, Bogdanova A, Okaz E, Habermann B, et al. Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis. Dev Cell. 2010;18:397-409 pubmed publisher
    ..and chiasmata holding bivalent chromosomes together are resolved by cleavage of cohesin's alpha-kleisin subunit (Rec8) along chromosome arms...