Gene Symbol: REB1
Description: DNA-binding protein REB1
Alias: GRF2, DNA-binding protein REB1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Fath S, Milkereit P, Podtelejnikov A, Bischler N, Schultz P, Bier M, et al. Association of yeast RNA polymerase I with a nucleolar substructure active in rRNA synthesis and processing. J Cell Biol. 2000;149:575-90 pubmed
    ..Our results support the idea that a functional nucleolar subdomain formed independently of the state of rDNA transcription may serve as a scaffold for coordinated rRNA synthesis and processing. ..
  2. McCullagh E, Seshan A, El Samad H, Madhani H. Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat Cell Biol. 2010;12:954-62 pubmed publisher
    ..Consequently, cells may have evolved mechanisms to suppress noise by controlling these interactions. ..
  3. Lin L, Chamberlain L, Zhu L, Green M. Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4. Proc Natl Acad Sci U S A. 2012;109:1997-2002 pubmed publisher
    ..Finally, we show that although Tra1 is targeted by other activators, these interactions are unaffected by GID mutations, revealing an unanticipated specificity of the Gal4-Tra1 interaction. ..
  4. Wang Q, Donze D. Transcription factor Reb1 is required for proper transcriptional start site usage at the divergently transcribed TFC6-ESC2 locus in Saccharomyces cerevisiae. Gene. 2016;594:108-116 pubmed publisher
    ..cerevisiae, these regions are adjacent to binding sites for general regulatory transcription factors, and the Reb1 protein is commonly bound to promoter DNA near such regions...
  5. Matveenko A, Belousov M, Bondarev S, Moskalenko S, Zhouravleva G. [Identification of new genes that affect [PSI^(+)] prion toxicity in Saccharomyces cerevisiae yeast]. Mol Biol (Mosk). 2016;50:803-813 pubmed
    ..It was found that ABF1, FKH2, and REB1 overexpression decreased the growth of strains in a prion-dependent manner and, thus, might influence [PSI^(+)] ..
  6. Koerber R, Rhee H, Jiang C, Pugh B. Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome. Mol Cell. 2009;35:889-902 pubmed publisher
    ..including those that (1) bind histones (Bdf1/SWR1 and Srm1), (2) bind specific DNA sequences (Rap1 and Reb1), and (3) potentially collide with nucleosomes during transcription (RNA polymerase II)...
  7. Mayan M. RNAP-II transcribes two small RNAs at the promoter and terminator regions of the RNAP-I gene in Saccharomyces cerevisiae. Yeast. 2013;30:25-32 pubmed publisher
    ..This report suggests that cryptic transcription by RNAP-II may be required for normal transcription by RNAP-I in the ribosomal locus of S. cerevisiae. ..
  8. Kamei Y, Tai A, Dakeyama S, Yamamoto K, Inoue Y, Kishimoto Y, et al. Transcription factor genes essential for cell proliferation and replicative lifespan in budding yeast. Biochem Biophys Res Commun. 2015;463:351-6 pubmed publisher
    ..Heterozygous diploid knockout strains for FHL1, RAP1, REB1, and MCM1 genes showed significantly short lifespan...
  9. Jeong S, Lang W, Reeder R. The release element of the yeast polymerase I transcription terminator can function independently of Reb1p. Mol Cell Biol. 1995;15:5929-36 pubmed
    ..We discuss possible mechanisms whereby this polI release element might function. ..

More Information


  1. Wang K, Warner J. Positive and negative autoregulation of REB1 transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:4368-76 pubmed
    ..Studies of the transcriptional control of the REB1 gene have led us to identify three Reb1p binding sites in the 5' region of the its gene, termed A, B, and C, at ..
  2. Colin J, Candelli T, PorrĂșa O, Boulay J, Zhu C, Lacroute F, et al. Roadblock termination by reb1p restricts cryptic and readthrough transcription. Mol Cell. 2014;56:667-80 pubmed publisher
    ..This work demonstrates the importance of roadblock termination for controlling pervasive transcription and preventing transcription through gene regulatory regions. ..
  3. Bosio M, Fermi B, Spagnoli G, Levati E, Rubbi L, Ferrari R, et al. Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast. Nucleic Acids Res. 2017;45:4493-4506 pubmed publisher
    ..promoters also contain binding sites for one or more General Regulatory Factors (GRFs), most frequently Abf1 and Reb1, and that these factors are enriched in vivo at Ribi promoters...