Gene Symbol: RCF1
Alias: AIM31, Rcf1p
Species: Saccharomyces cerevisiae S288c
Chen Y, Taylor E, Dephoure N, Heo J, Tonhato A, Papandreou I, et al
. Identification of a protein mediating respiratory supercomplex stability. Cell Metab. 2012;15:348-60 pubmed publisher
..We have identified a conserved mitochondrial protein, named respiratory supercomplex factor 1 (Rcf1-Yml030w), that is required for the normal assembly of respiratory supercomplexes...
McStay G, Su C, Thomas S, Xu J, Tzagoloff A. Characterization of assembly intermediates containing subunit 1 of yeast cytochrome oxidase. J Biol Chem. 2013;288:26546-56 pubmed publisher
Strogolova V, Furness A, Robb McGrath M, Garlich J, Stuart R. Rcf1 and Rcf2, members of the hypoxia-induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol. 2012;32:1363-73 pubmed publisher
We report that Rcf1 (formerly Aim31), a member of the conserved hypoxia-induced gene 1 (Hig1) protein family, represents a novel component of the yeast cytochrome bc(1)-cytochrome c oxidase (COX) supercomplex...
Garlich J, Strecker V, Wittig I, Stuart R. Mutational Analysis of the QRRQ Motif in the Yeast Hig1 Type 2 Protein Rcf1 Reveals a Regulatory Role for the Cytochrome c Oxidase Complex. J Biol Chem. 2017;292:5216-5226 pubmed publisher
The yeast Rcf1 protein is a member of the conserved family of proteins termed the hypoxia-induced gene (domain) 1 (Hig1 or HIGD1) family...
Su C, McStay G, Tzagoloff A. The Cox3p assembly module of yeast cytochrome oxidase. Mol Biol Cell. 2014;25:965-76 pubmed publisher
..In addition to subunits of COX, some Cox3p intermediates contain Rcf1p, a protein associated with the supercomplex that stabilizes the interaction of COX with the bc1 (ubiquinol-..
Hildenbeutel M, Hegg E, Stephan K, Gruschke S, Meunier B, Ott M. Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation. J Cell Biol. 2014;205:511-24 pubmed publisher
..Failure to hemylate cytochrome b sequesters the Cbp3-Cbp6 complex in early assembly intermediates, thereby causing a reduction in cytochrome b synthesis via a feedback loop that senses hemylation of cytochrome b. ..
Rydström Lundin C, von Ballmoos C, Ott M, Adelroth P, Brzezinski P. Regulatory role of the respiratory supercomplex factors in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2016;113:E4476-85 pubmed publisher
..bc1-CytcO quinol oxidation-oxygen-reduction activities in mitochondria in which Rcf1 or Rcf2 were removed genetically (strains rcf1? and rcf2?, respectively)...
Römpler K, Müller T, Juris L, Wissel M, Vukotic M, Hofmann K, et al
. Overlapping Role of Respiratory Supercomplex Factor Rcf2 and Its N-terminal Homolog Rcf3 in Saccharomyces cerevisiae. J Biol Chem. 2016;291:23769-23778 pubmed
..We show that the previously uncharacterized Rcf3 (YBR255c-A) is a homolog of the N-terminal Rcf2 peptide, whereas Rcf1 is homologous to the C-terminal portion...