Gene Symbol: PYC2
Description: pyruvate carboxylase 2
Alias: pyruvate carboxylase 2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Haarasilta S, Taskinen L. Location of three key enzymes of gluconeogenesis in baker's yeast. Arch Microbiol. 1977;113:159-61 pubmed
    ..On the evidence obtained from zonal separations these three enzymes of gluconeogenesis are most probably located in the soluble cytosol...
  2. Brewster N, Val D, Walker M, Wallace J. Regulation of pyruvate carboxylase isozyme (PYC1, PYC2) gene expression in Saccharomyces cerevisiae during fermentative and nonfermentative growth. Arch Biochem Biophys. 1994;311:62-71 pubmed
    ..cerevisiae there are two isoenzymes of pyruvate carboxylase (Pyc) encoded by separate genes, designated PYC1 and PYC2. In the wild type yeast, the expression of both genes is influenced by both the growth phase and the type of carbon ..
  3. Blazquez M, Gamo F, Gancedo C. A mutation affecting carbon catabolite repression suppresses growth defects in pyruvate carboxylase mutants from Saccharomyces cerevisiae. FEBS Lett. 1995;377:197-200 pubmed
    Yeasts with disruptions in the genes PYC1 and PYC2 encoding the isoenzymes of pyruvate carboxylase cannot grow in a glucose-ammonium medium (Stucka et al. (1991) Mol. Gen. Genet. 229, 307-315)...
  4. Lee J, Tsoi A, Kornfeld G, Dawes I. Cellular responses to L-serine in Saccharomyces cerevisiae: roles of general amino acid control, compartmentalization, and aspartate synthesis. FEMS Yeast Res. 2013;13:618-34 pubmed publisher
    ..L-aspartate synthesis was exclusively through mitochondrial metabolism of L-serine to pyruvate and ammonia, involving Cha1p, cytoplasmic pyruvate carboxylases Pyc1p and Pyc2p, and the cytoplasmic aspartate aminotransferase Aat2p. ..
  5. Walker M, Val D, Rohde M, Devenish R, Wallace J. Yeast pyruvate carboxylase: identification of two genes encoding isoenzymes. Biochem Biophys Res Commun. 1991;176:1210-7 pubmed
    ..We have mapped the genes encoding both enzymes and shown the previously characterised gene, designated PYC1, to be on chromosome VII whilst PYC2 is on chromosome II.
  6. van Urk H, Schipper D, Breedveld G, Mak P, Scheffers W, van Dijken J. Localization and kinetics of pyruvate-metabolizing enzymes in relation to aerobic alcoholic fermentation in Saccharomyces cerevisiae CBS 8066 and Candida utilis CBS 621. Biochim Biophys Acta. 1989;992:78-86 pubmed
    ..Rather, a high glycolytic flux and a high level of this enzyme are decisive for the occurrence of alcoholic fermentation after transfer of cells from glucose limitation to glucose excess. ..
  7. Ursic D, Chinchilla K, Finkel J, Culbertson M. Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing. Nucleic Acids Res. 2004;32:2441-52 pubmed
    ..The protein-protein and protein-RNA interactions reported here suggest that the DNA/RNA helicase activity of Sen1p is utilized for several different purposes in multiple gene expression pathways. ..
  8. Suga H, Matsuda F, Hasunuma T, Ishii J, Kondo A. Implementation of a transhydrogenase-like shunt to counter redox imbalance during xylose fermentation in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2013;97:1669-78 pubmed publisher
    ..shunt, including malic enzyme (encoded by MAE1), malate dehydrogenase (MDH2), and pyruvate carboxylase (PYC2), were overexpressed to regulate the redox state in xylose-fermenting recombinant Saccharomyces cerevisiae...