Gene Symbol: PXA1
Description: ATP-binding cassette long-chain fatty acid transporter PXA1
Alias: LPI1, PAL1, PAT2, SSH2, ATP-binding cassette long-chain fatty acid transporter PXA1
Species: Saccharomyces cerevisiae S288c
Shani N, Valle D. A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Natl Acad Sci U S A. 1996;93:11901-6 pubmed
..ALDP and PMP70 share sequence homology and both are implicated in genetic diseases. PXA1 and YKL741 are Saccharomyces cerevisiae genes that encode homologs of ALDP and PMP70...
van Roermund C, Visser W, IJlst L, van Cruchten A, Boek M, Kulik W, et al
. The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters. FASEB J. 2008;22:4201-8 pubmed publisher
..Interestingly, we found that the mutant phenotype of the pxa1/pxa2Delta mutant can be rescued, at least partially, by the sole expression of the human ABCD1 cDNA coding for ALDP,..
Hettema E, van Roermund C, Distel B, Van den Berg M, Vilela C, Rodrigues Pousada C, et al
. The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J. 1996;15:3813-22 pubmed
..Pat1p and Pat2p are the first examples of membrane proteins involved in metabolite transport across the peroxisomal membrane...
Nyathi Y, De Marcos Lousa C, Van Roermund C, Wanders R, Johnson B, Baldwin S, et al
. The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity. J Biol Chem. 2010;285:29892-902 pubmed publisher
..The yeast pxa1 pxa2? mutant lacks the homologous peroxisomal ABC transporter and is unable to grow on oleic acid...
Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al
. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher
Chuang C, Chen L, Fu R, Chen S, Ho M, Huang J, et al
. Involvement of the carboxyl-terminal region of the yeast peroxisomal half ABC transporter Pxa2p in its interaction with Pxa1p and in transporter function. PLoS ONE. 2014;9:e104892 pubmed publisher
..The CT of Pxa2p is involved in its interaction with Pxa1p and in transporter function. This concept may be applied to human ALDP studies, helping to establish the pathological mechanism for CT-related X-ALD disease. ..
van Roermund C, Visser W, IJlst L, Waterham H, Wanders R. Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid ?-oxidation. Biochim Biophys Acta. 2011;1811:148-52 pubmed publisher
..We here report that the phenotype of the pxa1/pxa2? yeast mutant, i.e...
Carroll S, Stimpson H, Weinberg J, Toret C, Sun Y, Drubin D. Analysis of yeast endocytic site formation and maturation through a regulatory transition point. Mol Biol Cell. 2012;23:657-68 pubmed publisher
..Our results are consistent with a role for cargo in regulating the transition of endocytic sites from the early stages of formation to the late stages during which vesicle formation occurs...