Gene Symbol: PUF2
Species: Saccharomyces cerevisiae S288c
Gerber A, Herschlag D, Brown P. Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol. 2004;2:E79 pubmed
..Puf proteins: Puf3p binds nearly exclusively to cytoplasmic mRNAs that encode mitochondrial proteins; Puf1p and Puf2p interact preferentially with mRNAs encoding membrane-associated proteins; Puf4p preferentially binds mRNAs ..
Ulbricht R, Olivas W. Puf1p acts in combination with other yeast Puf proteins to control mRNA stability. RNA. 2008;14:246-62 pubmed
Olivas W, Parker R. The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast. EMBO J. 2000;19:6602-11 pubmed
..we analyzed the role of five members of the Puf family present in the yeast genome (referred to as JSN1/PUF1, PUF2, PUF3, PUF4 and MPT5/PUF5)...
Cridge A, Castelli L, Smirnova J, Selley J, Rowe W, Hubbard S, et al
. Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res. 2010;38:8039-50 pubmed publisher
..to uncover specific RNA-stabilized complexes formed between Caf20p and Puf4p/Puf5p and between Eap1p and Puf1p/Puf2p. Thus the combined action of each 4E-BP with specific 3'-UTR-binding proteins mediates mRNA-specific translational ..
Yosefzon Y, Koh Y, Chritton J, Lande A, Leibovich L, Barziv L, et al
. Divergent RNA binding specificity of yeast Puf2p. RNA. 2011;17:1479-88 pubmed publisher
..We focus here on the specificity of Puf2p and Puf1p of Saccharomyces cerevisiae, which copurify with overlapping groups of mRNAs...
Kraut Cohen J, Afanasieva E, Haim Vilmovsky L, Slobodin B, Yosef I, Bibi E, et al
. Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae. Mol Biol Cell. 2013;24:3069-84 pubmed publisher
..Overall we show that mSMP targeting to the ER is both translation- and SRP-independent, and regulated by cis elements contained within the message and trans-acting RNA-binding proteins (e.g., She2, Puf2).
Porter D, Koh Y, VanVeller B, Raines R, Wickens M. Target selection by natural and redesigned PUF proteins. Proc Natl Acad Sci U S A. 2015;112:15868-73 pubmed publisher
..the in vivo RNA binding sites of wild-type (WT) and reengineered forms of the PUF protein Saccharomyces cerevisiae Puf2p across the transcriptome...