Gene Symbol: PTC6
Description: type 2C protein phosphatase PTC6
Alias: AUP1, PPP2, type 2C protein phosphatase PTC6
Species: Saccharomyces cerevisiae S288c
Ruan H, Yan Z, Sun H, Jiang L. The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res. 2007;7:209-15 pubmed
..Therefore, YCR079w encodes the sixth PP2C, PTC6, in budding yeast.
Tal R, Winter G, Ecker N, Klionsky D, Abeliovich H. Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem. 2007;282:5617-24 pubmed
..Our data suggest that Aup1p may be part of a signal transduction mechanism that marks mitochondria for sequestration into autophagosomes. ..
Gey U, Czupalla C, Hoflack B, Rödel G, Krause Buchholz U. Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem. 2008;283:9759-67 pubmed publisher
..Both proteins are associated with the complex. We propose a model for the role of the regulatory enzymes and the phosphorylation state of Pda1p in the assembly process of the pyruvate dehydrogenase complex. ..
Journo D, Mor A, Abeliovich H. Aup1-mediated regulation of Rtg3 during mitophagy. J Biol Chem. 2009;284:35885-95 pubmed publisher
..We recently identified a conserved mitochondrial protein phosphatase homolog, Aup1, which is required for efficient stationary phase mitophagy in yeast...
Luhtala N, Parker R. LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels. Nucleic Acids Res. 2009;37:5529-36 pubmed publisher
..These results suggest that inhibition of splicing and/or deadenylation may be effective therapies for Lsm1-over-expressing tumors. ..
González A, Casado C, Arino J, Casamayor A. Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae. PLoS ONE. 2013;8:e64470 pubmed publisher
b>Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood...
Sharmin D, Sasano Y, Sugiyama M, Harashima S. Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae. Yeast. 2014;31:393-409 pubmed publisher
..Interestingly, the septuple disruptant ?ptc1?ptc2?ptc3?ptc4?ptc5?ptc6?ptc7 showed an essentially normal growth phenotype at 37°C...
Sharmin D, Sasano Y, Sugiyama M, Harashima S. Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae. J Biosci Bioeng. 2015;119:392-8 pubmed publisher
..Here, we sought to determine the cellular role of PTC6 in S.Â cerevisiae with disruption of PTC genes...
Guo X, Niemi N, Coon J, Pagliarini D. Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase. J Biol Chem. 2017;292:11751-11759 pubmed publisher
..Our findings highlight the power of integrative omics and biochemical analyses for annotating the functions of poorly characterized signaling proteins. ..