PTC5

Summary

Gene Symbol: PTC5
Description: type 2C protein phosphatase PTC5
Alias: PPP1, type 2C protein phosphatase PTC5
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Krause Buchholz U, Gey U, Wünschmann J, Becker S, Rödel G. YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex. FEBS Lett. 2006;580:2553-60 pubmed
    ..We demonstrate by means of blue native gel electrophoresis and tandem affinity purification that both enzymes are associated with the PDH complex. ..
  2. Gey U, Czupalla C, Hoflack B, Rödel G, Krause Buchholz U. Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem. 2008;283:9759-67 pubmed publisher
    ..Both proteins are associated with the complex. We propose a model for the role of the regulatory enzymes and the phosphorylation state of Pda1p in the assembly process of the pyruvate dehydrogenase complex. ..
  3. Vögtle F, Burkhart J, Rao S, Gerbeth C, Hinrichs J, Martinou J, et al. Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics. 2012;11:1840-52 pubmed publisher
    ..as substrates of the MIA import pathway that have unusual cysteine motifs and found the protein phosphatase Ptc5 to be a novel substrate of the inner membrane protease (IMP)...
  4. Sharmin D, Sasano Y, Sugiyama M, Harashima S. Effects of deletion of different PP2C protein phosphatase genes on stress responses in Saccharomyces cerevisiae. Yeast. 2014;31:393-409 pubmed publisher
    ..However, several combinations exhibited novel phenotypes, e.g. the ?ptc5?ptc7 double disruptant and the ?ptc2?ptc3?ptc5?ptc7 quadruple disruptant exhibited low (13°C) and high (37°C) ..
  5. Cheng A, Ross K, Kaldis P, Solomon M. Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev. 1999;13:2946-57 pubmed
    ..Furthermore, PP2C-like enzymes are the predominant phosphatases toward human Cdk2 in HeLa cell extracts, indicating that the substrate specificity of PP2Cs toward CDKs is evolutionarily conserved. ..