PTC2

Summary

Gene Symbol: PTC2
Description: Ptc2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. ncbi Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase
    A A Welihinda
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Mol Cell Biol 18:1967-77. 1998
  2. ncbi Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination
    Jung Ae Kim
    Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454 9110, USA
    Mol Cell Biol 31:507-16. 2011
  3. ncbi A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic data
    Willy Aucher
    Laboratoire du Métabolisme de l ADN et Réponses aux Génotoxiques, Gif Sur Yvette F 91191, France
    Mol Cell Proteomics 9:2745-59. 2010
  4. ncbi Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication
    Marco Bazzi
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Milan, Italy
    Mol Cell Biol 30:131-45. 2010
  5. ncbi Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae
    Shawn J Szyjka
    Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA
    Genes Dev 22:1906-20. 2008
  6. ncbi Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53
    Anna Travesa
    Department of Biochemistry and Molecular Biology, School of Medicine, and the Center for Biophysical Studies, Universitat Autonoma de Barcelona, Bellaterra, Catalonia, Spain
    J Biol Chem 283:17123-30. 2008
  7. ncbi Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage
    Bryan M O'Neill
    Departments of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:9290-5. 2007
  8. ncbi Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression
    Peter C Stirling
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
    Mol Biol Cell 18:2336-45. 2007
  9. ncbi Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae
    Ghislaine Guillemain
    CEA, Direction des Sciences du Vivant, Institut de Biologie et de la Technologies de Saclay, 91191 Gif sur Yvette Cedex, France
    Mol Cell Biol 27:3378-89. 2007
  10. ncbi Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae
    Atsunori Shitamukai
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8530, Japan
    J Biol Chem 279:3651-61. 2004

Scientific Experts

  • Shawn J Szyjka
  • Marie Claude Marsolier-Kergoat
  • Francoise Ochsenbein
  • Raphael Guerois
  • Jung Ae Kim
  • Tracey J Au
  • Marco Bazzi
  • Willy Aucher
  • Emilie Ma
  • Simona Miron
  • Anna Travesa
  • Oscar M Aparicio
  • Ghislaine Guillemain
  • Bryan M O'Neill
  • James E Haber
  • Peter C Stirling
  • Marie-Claude Marsolier-Kergoat
  • Atsunori Shitamukai
  • Ivan Munoz
  • Christophe Leroy
  • Kentaro Ohkuni
  • Naoko Sakumoto
  • Christian Young
  • J Warmka
  • Jairo Rodriguez
  • Wade M Hicks
  • Sue Yen Tay
  • Jin Li
  • Toshio Tsukiyama
  • Jack A Vincent
  • Camilla Trovesi
  • M C Marsolier
  • Maria Pia Longhese
  • Emmanuelle Becker
  • Davide Mantiero
  • Giovanna Lucchini
  • Arnaud Martel
  • Alba Duch
  • Simon Knott
  • Simon Tavare
  • Jennifer G Aparicio
  • David G Quintana
  • Christopher J Viggiani
  • Weihong Xu
  • A Cheng
  • John R Yates
  • Anthony A Hyman
  • Karam S Takhar
  • Robert Thai
  • Ewa T Lis
  • Aaron O Bailey
  • Andrei Pozniakovsky
  • Martin Srayko
  • Floyd E Romesberg
  • Sarah Mauger
  • Michel R Leroux
  • A A Welihinda
  • Tokichi Miyakawa
  • Shinya Sonobe
  • Dai Hirata
  • Moreshwar B Vaze
  • Joaquin Arino
  • Josep Clotet
  • Françoise Ochsenbien
  • Asuko Okuda
  • Sang Eun Lee
  • Ernesto Simon
  • Nuria Casals
  • Akihiko Kikuchi
  • Nobuo Ogawa
  • Itsumi Matsuoka
  • Yukio Mukai
  • Jennifer Hanneman
  • Irene Ota
  • Sheikha Al-Zarban
  • Satoshi Harashima
  • Yoshinobu Kaneko
  • James Mapes
  • D Amin
  • J Lee
  • J Hanneman
  • I Ota
  • P Roussel
  • C Mann
  • C Leroy
  • M J Solomon
  • P Kaldis
  • K E Ross
  • W Tirasophon
  • R J Kaufman

Detail Information

Publications19

  1. ncbi Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase
    A A Welihinda
    Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Mol Cell Biol 18:1967-77. 1998
    ..Searching for proteins that interact with Ire1p in Saccharomyces cerevisiae, we isolated PTC2, which encodes a serine/threonine phosphatase of type 2C...
  2. ncbi Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination
    Jung Ae Kim
    Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454 9110, USA
    Mol Cell Biol 31:507-16. 2011
    ..Recovery involves two members of the protein phosphatase 2C (PP2C) family, Ptc2 and Ptc3, as well as the protein phosphatase 4 (PP4) enzyme, Pph3...
  3. ncbi A strategy for interaction site prediction between phospho-binding modules and their partners identified from proteomic data
    Willy Aucher
    Laboratoire du Métabolisme de l ADN et Réponses aux Génotoxiques, Gif Sur Yvette F 91191, France
    Mol Cell Proteomics 9:2745-59. 2010
    ..The STRIP method relies on a combination of conservation, phosphorylation likelihood, and binding specificity criteria and can be accessed via a web interface at http://biodev.extra.cea.fr/strip/...
  4. ncbi Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication
    Marco Bazzi
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Milan, Italy
    Mol Cell Biol 30:131-45. 2010
    ..inactivation during methylmethane sulfonate exposure, which instead requires the protein phosphatases Pph3, Ptc2, and Ptc3...
  5. ncbi Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae
    Shawn J Szyjka
    Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA
    Genes Dev 22:1906-20. 2008
    ..Furthermore, combined deletion of PPH3 and PTC2, a second, unrelated Rad53 phosphatase, results in complete replication fork arrest and lethality in MMS, ..
  6. ncbi Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53
    Anna Travesa
    Department of Biochemistry and Molecular Biology, School of Medicine, and the Center for Biophysical Studies, Universitat Autonoma de Barcelona, Bellaterra, Catalonia, Spain
    J Biol Chem 283:17123-30. 2008
    ..a persistent double strand break in G(2)/M has been shown to depend on the presence of the PP2C-type phosphatases Ptc2 and Ptc3...
  7. ncbi Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage
    Bryan M O'Neill
    Departments of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:9290-5. 2007
    ..These findings suggest that Rad53 regulates replication fork restart and initiation of late firing origins independently and that regulation of these processes is mediated by specific Rad53 phosphatases...
  8. ncbi Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression
    Peter C Stirling
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
    Mol Biol Cell 18:2336-45. 2007
    ..Our data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2...
  9. ncbi Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae
    Ghislaine Guillemain
    CEA, Direction des Sciences du Vivant, Institut de Biologie et de la Technologies de Saclay, 91191 Gif sur Yvette Cedex, France
    Mol Cell Biol 27:3378-89. 2007
    ..We have previously provided evidence that the phosphatases Ptc2 and Ptc3 of the protein phosphatase 2C type are required for DNA checkpoint inactivation after a DSB and probably ..
  10. ncbi Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae
    Atsunori Shitamukai
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8530, Japan
    J Biol Chem 279:3651-61. 2004
    ....
  11. ncbi Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity
    Kentaro Ohkuni
    Laboratory of Medical Mycology, Research Institute for Disease Mechanism and Control, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Genetics 165:517-29. 2003
    ....
  12. ncbi PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break
    Christophe Leroy
    Service de Biochimie et de Génétique Moléculaire, CEA Saclay, 91191 Gif sur Yvette, Cedex, France
    Mol Cell 11:827-35. 2003
    ..Cells lacking the PP2C-like phosphatases Ptc2 and Ptc3 are unable to adapt to a HO-induced DSB and are also defective in recovering from a repairable DSB...
  13. ncbi Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae
    Ivan Munoz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
    Yeast 20:157-69. 2003
    ..The possible relationship between the known functions of these suppressor genes and the progress through the G(1)-S transition is discussed...
  14. ncbi Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation
    Christian Young
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 0215, USA
    Eukaryot Cell 1:1032-40. 2002
    ..b>Ptc2 and Ptc3 are 75% identical to each other and differ from Ptc1 in having a noncatalytic domain...
  15. ncbi A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis
    Naoko Sakumoto
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Yeast 19:587-99. 2002
    ..3 M CaCl(2). The double msg5 ptc2 disruptant failed to grow on medium containing 1...
  16. ncbi Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1
    J Warmka
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 0215, USA
    Mol Cell Biol 21:51-60. 2001
    ..Three type 2C Ser/Thr phosphatases (PTCs), Ptc1, Ptc2, and Ptc3, have been isolated as negative regulators of this pathway...
  17. ncbi Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae
    M C Marsolier
    Service de Biochimie et de Génétique Moléculaire, CEA Saclay, 91191 Gif sur Yvette Cedex, France
    Genetics 154:1523-32. 2000
    ..searched for genes whose overexpression suppressed the toxicity of a dominant-lethal form of RAD53 and identified PTC2, which encodes a protein phosphatase of the PP2C family...
  18. ncbi Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases
    A Cheng
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520 8024, USA
    Genes Dev 13:2946-57. 1999
    ..Overexpression of PTC2 or PTC3 results in synthetic lethality in strains temperature-sensitive for yeast CAK1, and disruptions of PTC2 and ..
  19. ncbi ATP-dependent chromatin remodeling factors tune S phase checkpoint activity
    Tracey J Au
    Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 31:4454-63. 2011
    ..Based on these results, we propose that Isw2 and Ino80 are targeted to stalled replication forks via RPA and directly control the amplitude of S phase checkpoint activity and the subsequent deactivation process...