PSK2

Summary

Gene Symbol: PSK2
Description: serine/threonine protein kinase PSK2
Alias: serine/threonine protein kinase PSK2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ouyang Y, Xu Q, Mitsui K, Motizuki M, Xu Z. PSK2 coordinates glucose metabolism and utilization to maintain ultradian clock-coupled respiratory oscillation in Saccharomyces cerevisiae yeast. Arch Biochem Biophys. 2011;509:52-8 pubmed publisher
    ..The purpose of the present study was to determine the role of PSK2 kinase in UCRO in yeast. S...
  2. Rutter J, Probst B, McKnight S. Coordinate regulation of sugar flux and translation by PAS kinase. Cell. 2002;111:17-28 pubmed
    ..These studies provide evidence of a cell-autonomous signaling system that both controls and connects the balance of fuel consumption/storage to protein synthesis. ..
  3. Smith T, Rutter J. Regulation of glucose partitioning by PAS kinase and Ugp1 phosphorylation. Mol Cell. 2007;26:491-9 pubmed
    ..The paralogous yeast PAS kinases Psk1 and Psk2 phosphorylate UDP-glucose pyrophosphorylase (Ugp1), the primary producer of UDP-glucose, the glucose donor for ..
  4. Demille D, Badal B, Evans J, Mathis A, Anderson J, Grose J. PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1. Mol Biol Cell. 2015;26:569-82 pubmed publisher
    ..This interplay between yeast SNF1, Psk1, and TORC1 allows for proper glucose allocation during nutrient depletion, reducing cell growth and proliferation when energy is low. ..
  5. Cardon C, Beck T, Hall M, Rutter J. PAS kinase promotes cell survival and growth through activation of Rho1. Sci Signal. 2012;5:ra9 pubmed publisher
    ..cerevisiae, phosphorylation of Ugp1 by either of the yeast PASK family protein kinases (yPASK), Psk1 or Psk2, directs this metabolic enzyme to deliver glucose to the periphery for synthesis of the cell wall...
  6. Grose J, Smith T, Sabic H, Rutter J. Yeast PAS kinase coordinates glucose partitioning in response to metabolic and cell integrity signaling. EMBO J. 2007;26:4824-30 pubmed
    ..These pathways differentially activate the two PAS kinase proteins in Saccharomyces cerevisiae, Psk1 and Psk2, with Psk1 alone responding to activation by nonfermentative carbon sources...
  7. Jeon S, Lim S, Ha J, Kim J. Identification of Psk2, Skp1, and Tub4 as trans-acting factors for uORF-containing ROK1 mRNA in Saccharomyces cerevisiae. J Microbiol. 2015;53:616-22 pubmed publisher
    ..We identified Psk2 (PAS kinase), Skp1 (kinetochore protein) and Tub4 (γ-tubulin protein) as ROK1 5'UTR-interacting proteins using ..