Gene Symbol: PSD2
Description: phosphatidylserine decarboxylase 2
Alias: phosphatidylserine decarboxylase 2
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Trotter P, Voelker D. Identification of a non-mitochondrial phosphatidylserine decarboxylase activity (PSD2) in the yeast Saccharomyces cerevisiae. J Biol Chem. 1995;270:6062-70 pubmed
    ..The present studies demonstrate the presence of a second enzyme activity (denoted PSD2), which, depending on the method of evaluation, accounts for 4-12% of the total cellular phosphatidylserine ..
  2. Storey M, Clay K, Kutateladze T, Murphy R, Overduin M, Voelker D. Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem. 2001;276:48539-48 pubmed
    ..The essential function of the PtdEtn in the presence of propanolamine does not appear to be the formation of hexagonal phase lipid, insofar as PtdPrn readily forms hexagonal phase structures detectable by (31)P NMR. ..
  3. Schumacher M, Choi J, Voelker D. Phosphatidylserine transport to the mitochondria is regulated by ubiquitination. J Biol Chem. 2002;277:51033-42 pubmed
    ..These data provide compelling evidence that interorganelle PtdSer traffic is regulated by ubiquitination. ..
  4. Gulshan K, Shahi P, Moye Rowley W. Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance. Mol Biol Cell. 2010;21:443-55 pubmed publisher
    ..Saccharomyces cerevisiae has two different phosphatidylserine decarboxylase enzymes (Psd1 and Psd2) that catalyze formation of phosphatidylethanolamine...
  5. Rosenberger S, Connerth M, Zellnig G, Daum G. Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2009;1791:379-87 pubmed publisher
    ..The fact that peroxisomes were always found in close vicinity to mitochondria, ER and lipid particles supported the view that membrane contact may play a role in lipid traffic between these organelles. ..
  6. Schuiki I, Schnabl M, Czabany T, Hrastnik C, Daum G. Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2010;1801:480-6 pubmed publisher
    ..phosphatidylserine (PS) by (i) phosphatidylserine decarboxylase 1 (Psd1p) in mitochondria and (ii) phosphatidylserine decarboxylase 2 (Psd2p) in a Golgi/vacuolar compartment, (iii) incorporation of exogenous ethanolamine and ..
  7. Nguyen T, Lewandowska A, Choi J, Markgraf D, Junker M, Bilgin M, et al. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012;13:880-90 pubmed publisher
    ..Finally, we show that ERMES complexes are long-lived, and do not depend on the presence of Gem1. Our findings suggest that the ERMES complex may have primarily a structural role in maintaining mitochondrial morphology. ..
  8. Gohil V, Thompson M, Greenberg M. Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae. J Biol Chem. 2005;280:35410-6 pubmed
    ..lethal with the crd1delta mutant, whereas deletion of the Golgi and endoplasmic reticulum pathway genes PSD2 and DPL1 did not result in synthetic lethality...
  9. Deng L, Kakihara T, Fukuda R, Ohta A. Isolation and characterization of a mutant defective in utilization of exogenous phosphatidylethanolamine in Saccharomyces cerevisiae. J Gen Appl Microbiol. 2007;53:255-8 pubmed

More Information


  1. Nebauer R, Schuiki I, Kulterer B, Trajanoski Z, Daum G. The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. FEBS J. 2007;274:6180-90 pubmed
    ..In summary, our results demonstrate a link between the mitochondrial protein import machinery, assembly and stability of Psd1p, and phosphatidylethanolamine homeostasis in yeast mitochondria. ..
  2. Horvath S, Wagner A, Steyrer E, Daum G. Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2011;1811:1030-7 pubmed publisher
    ..Moreover, it is very likely that local availability of PE in microsomes is crucial for TAG synthesis through the Lro1p reaction. ..
  3. Takeda M, Yamagami K, Tanaka K. Role of phosphatidylserine in phospholipid flippase-mediated vesicle transport in Saccharomyces cerevisiae. Eukaryot Cell. 2014;13:363-75 pubmed publisher
    ..These results suggest that flippase-dependent vesicle formation is mediated by phospholipid flipping, not by flipped phospholipids. ..
  4. Wu W, Voelker D. Reconstitution of phosphatidylserine transport from chemically defined donor membranes to phosphatidylserine decarboxylase 2 implicates specific lipid domains in the process. J Biol Chem. 2004;279:6635-42 pubmed
    ..These data support a model for PtdSer transport from planar domains highly enriched in PtdSer or in PtdSer plus PtdOH. ..
  5. Toh e A, Oguchi T. Genetic characterization of genes encoding enzymes catalyzing addition of phospho-ethanolamine to the glycosylphosphatidylinositol anchor in Saccharomyces cerevisiae. Genes Genet Syst. 2002;77:309-22 pubmed
    ..b>PSD2, encoding another phosphatidylserine decarboxylase that is localized in Golgi/vacuole, was found to be able to ..
  6. Carson M, Emala M, Hogsten P, Waechter C. Coordinate regulation of phosphatidylserine decarboxylase activity and phospholipid N-methylation in yeast. J Biol Chem. 1984;259:6267-73 pubmed
    ..cerevisiae and provide evidence that its activity is regulated in coordination with other enzymes in the pathway for phosphatidylcholine biosynthesis involving N-methylation. ..
  7. Padilla Lopez S, Langager D, Chan C, Pearce D. BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution. Dis Model Mech. 2012;5:191-9 pubmed publisher
    ..In summary, lack of Btn1p alters phospholipid levels and might play a role in regulating their subcellular distribution. ..
  8. Tamura Y, Onguka O, Hobbs A, Jensen R, Iijima M, Claypool S, et al. Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. J Biol Chem. 2012;287:15205-18 pubmed publisher
    ..Our results suggest that Ups proteins and Mdm31p play important roles in phospholipid biosynthesis in mitochondria. Ups proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes. ..
  9. Riekhof W, Wu W, Jones J, Nikrad M, Chan M, Loewen C, et al. An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae. J Biol Chem. 2014;289:5809-19 pubmed publisher
    ..PstB2p, Psd2, and Pbi1p were shown to be lipid-binding proteins specific for phosphatidic acid...
  10. Wilson Zbinden C, Dos Santos A, Stoffel Studer I, van der Vaart A, Hofmann K, Reggiori F, et al. Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae. Genetics. 2015;199:475-85 pubmed publisher
  11. Miyata N, Miyoshi T, Yamaguchi T, Nakazono T, Tani M, Kuge O. VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae. Biochem J. 2015;472:319-28 pubmed publisher
    ..PSD1 null (psd1Δ) and PSD2 null (psd2Δ) mutants are viable in a synthetic minimal medium, but a psd1Δ psd2Δ double mutant exhibits ..
  12. Wu Y, Takar M, Cuentas Condori A, Graham T. Neo1 and phosphatidylethanolamine contribute to vacuole membrane fusion in Saccharomyces cerevisiae. Cell Logist. 2016;6:e1228791 pubmed
    ..Strains deficient in PE synthesis (psd1? psd2?) displayed fragmented vacuoles and the neo1-2 fragmented vacuole phenotype was also suppressed by ..
  13. Ogunbona O, Onguka O, Calzada E, Claypool S. Multitiered and Cooperative Surveillance of Mitochondrial Phosphatidylserine Decarboxylase 1. Mol Cell Biol. 2017;37: pubmed publisher