Gene Symbol: PSD1
Description: phosphatidylserine decarboxylase 1
Alias: phosphatidylserine decarboxylase 1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Trotter P, Voelker D. Identification of a non-mitochondrial phosphatidylserine decarboxylase activity (PSD2) in the yeast Saccharomyces cerevisiae. J Biol Chem. 1995;270:6062-70 pubmed
    Phosphatidylserine decarboxylase (PSD1) plays a central role in the biosynthesis of aminophospholipids in both prokaryotes and eukaryotes by catalyzing the synthesis of phosphatidylethanolamine. Recent reports (Trotter, P. J., Pedretti, J...
  2. Trotter P, Pedretti J, Voelker D. Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. J Biol Chem. 1993;268:21416-24 pubmed
    ..Analysis of lipid synthesis and enzyme activity in null mutants indicates that there are two PSD genes. ..
  3. Storey M, Clay K, Kutateladze T, Murphy R, Overduin M, Voelker D. Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem. 2001;276:48539-48 pubmed
    ..When the PSD1 gene is deleted, the resultant strain (psd1Delta) grows normally at 30 degrees C in glucose and in the absence of ..
  4. Schuiki I, Schnabl M, Czabany T, Hrastnik C, Daum G. Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2010;1801:480-6 pubmed publisher
    ..These pathways of PE formation are decarboxylation of phosphatidylserine (PS) by (i) phosphatidylserine decarboxylase 1 (Psd1p) in mitochondria and (ii) phosphatidylserine decarboxylase 2 (Psd2p) in a Golgi/vacuolar ..
  5. Birner R, Nebauer R, Schneiter R, Daum G. Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine biosynthetic machinery with the prohibitin complex of Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:370-83 pubmed
    ..PtdEtn), a phospholipid essential for aerobic growth of yeast cells, is synthesized by phosphatidylserine decarboxylase 1 (Psd1p) in the inner mitochondrial membrane (IMM)...
  6. Rosenberger S, Connerth M, Zellnig G, Daum G. Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2009;1791:379-87 pubmed publisher
    ..that defects in PE synthesis still allowed formation of peroxisomes, although these organelles from strains lacking PSD1 were significantly smaller than wild type...
  7. Gulshan K, Schmidt J, Shahi P, Moye Rowley W. Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression. Mol Cell Biol. 2008;28:5851-64 pubmed publisher
    ..Since the mitochondrially localized Psd1 enzyme provides a major route of PE biosynthesis, we evaluated the potential linkage between Psd1 function and PDR5 ..
  8. Shahi P, Gulshan K, Naar A, Moye Rowley W. Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae. Mol Biol Cell. 2010;21:2469-82 pubmed publisher
    ..Coimmunoprecipitation experiments revealed that association of Pdr3 with Med12 can only be detected in rho(0) cells. These experiments uncover the unique importance of Med12 in activated transcription of PDR5 seen in rho(0) cells. ..
  9. Toh e A, Oguchi T. Genetic characterization of genes encoding enzymes catalyzing addition of phospho-ethanolamine to the glycosylphosphatidylinositol anchor in Saccharomyces cerevisiae. Genes Genet Syst. 2002;77:309-22 pubmed
    ..Suppressors commonly effective to mpc1-4 and mpc1-5 mutations are PSD1, encoding phosphatidylserine decarboxylase, and ECM33, which were found to suppress the temperature-sensitive ..

More Information


  1. Deng L, Kakihara T, Fukuda R, Ohta A. Isolation and characterization of a mutant defective in utilization of exogenous phosphatidylethanolamine in Saccharomyces cerevisiae. J Gen Appl Microbiol. 2007;53:255-8 pubmed
  2. Wagner A, Di Bartolomeo F, Klein I, Hrastnik C, Doan K, Becker T, et al. Identification and characterization of the mitochondrial membrane sorting signals in phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:117-125 pubmed publisher
    b>Phosphatidylserine decarboxylase 1 (Psd1p) catalyzes the formation of the majority of phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae...
  3. Federovitch C, Jones Y, Tong A, Boone C, Prinz W, Hampton R. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:4506-20 pubmed publisher
    ..One of the HER genes identified was PSD1, which encodes the phospholipid biosynthetic enzyme phosphatidylserine decarboxylase...
  4. Horvath S, Wagner A, Steyrer E, Daum G. Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 2011;1811:1030-7 pubmed publisher
    ..Moreover, it is very likely that local availability of PE in microsomes is crucial for TAG synthesis through the Lro1p reaction. ..
  5. Tamura Y, Onguka O, Itoh K, Endo T, Iijima M, Claypool S, et al. Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. J Biol Chem. 2012;287:43961-71 pubmed publisher
    ..Restoration of Psd1p levels rescued PE production defects in ups1? mitochondria. Our data provide novel mechanistic insight into PE biogenesis in mitochondria. ..
  6. Kumanovics A, Poruk K, Osborn K, Ward D, Kaplan J. YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. J Biol Chem. 2006;281:22566-74 pubmed
  7. Onguka O, Calzada E, Ogunbona O, Claypool S. Phosphatidylserine decarboxylase 1 autocatalysis and function does not require a mitochondrial-specific factor. J Biol Chem. 2015;290:12744-52 pubmed publisher
    ..The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p)...
  8. Chan E, McQuibban G. Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1). J Biol Chem. 2012;287:40131-9 pubmed publisher
    ..b>Psd1 regulates the lipid and protein machineries of mitochondrial fusion...
  9. Joshi A, Thompson M, Fei N, Huttemann M, Greenberg M. Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae. J Biol Chem. 2012;287:17589-97 pubmed publisher
    ..To test this hypothesis, we constructed a conditional mutant crd1?psd1? containing null alleles of CRD1 (CL synthase) and PSD1 (mitochondrial phosphatidylserine decarboxylase), in which ..
  10. Horvath S, Böttinger L, Vögtle F, Wiedemann N, Meisinger C, Becker T, et al. Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. J Biol Chem. 2012;287:36744-55 pubmed publisher
    ..cerevisiae, the majority of cellular phosphatidylethanolamine is synthesized by the mitochondrial phosphatidylserine decarboxylase 1 (Psd1). The biogenesis of Psd1 involves several processing steps...
  11. Miyata N, Goda N, Matsuo K, Hoketsu T, Kuge O. Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae. Sci Rep. 2017;7:16447 pubmed publisher
    ..PS) transfer from the MOM to the MIM for phosphatidylethanolamine (PE) synthesis by a PS decarboxylase, Psd1. In this study, we found that the accumulation of CL in ups1? cells was enhanced by deletion of not only UPS2, but ..
  12. Ogunbona O, Onguka O, Calzada E, Claypool S. Multitiered and Cooperative Surveillance of Mitochondrial Phosphatidylserine Decarboxylase 1. Mol Cell Biol. 2017;37: pubmed publisher
    b>Phosphatidylserine decarboxylase 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane, must undergo an autocatalytic self-processing event to gain activity...
  13. Tamura Y, Harada Y, Nishikawa S, Yamano K, Kamiya M, Shiota T, et al. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab. 2013;17:709-18 pubmed publisher
    ..The present findings unveil the missing step of the cardiolipin synthesis pathway in mitochondria as well as the flexibile regulation of phospholipid biosynthesis to respond to compromised CDP-DAG synthesis in mitochondria. ..
  14. Nguyen T, Lewandowska A, Choi J, Markgraf D, Junker M, Bilgin M, et al. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012;13:880-90 pubmed publisher
    ..Finally, we show that ERMES complexes are long-lived, and do not depend on the presence of Gem1. Our findings suggest that the ERMES complex may have primarily a structural role in maintaining mitochondrial morphology. ..
  15. Carson M, Emala M, Hogsten P, Waechter C. Coordinate regulation of phosphatidylserine decarboxylase activity and phospholipid N-methylation in yeast. J Biol Chem. 1984;259:6267-73 pubmed
    ..cerevisiae and provide evidence that its activity is regulated in coordination with other enzymes in the pathway for phosphatidylcholine biosynthesis involving N-methylation. ..
  16. Imhof I, Flury I, Vionnet C, Roubaty C, Egger D, Conzelmann A. Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor. J Biol Chem. 2004;279:19614-27 pubmed
    ..Genetic manipulations to increase phosphatidylethanolamine levels in gpi7Delta cells by overexpression of PSD1 restore cell growth at 37 degrees C without restoring the addition of a substituent to Man2...
  17. Gohil V, Thompson M, Greenberg M. Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae. J Biol Chem. 2005;280:35410-6 pubmed
    ..Deletion of the mitochondrial PE pathway gene PSD1 was synthetically lethal with the crd1delta mutant, whereas deletion of the Golgi and endoplasmic reticulum pathway ..
  18. Han G, O Hara L, Carman G, Siniossoglou S. An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth. J Biol Chem. 2008;283:20433-42 pubmed publisher
    ..Mutations that decrease phosphatidate levels decrease nuclear membrane growth in pah1Delta cells. We propose that phosphatidate metabolism is a critical factor determining nuclear structure by regulating nuclear membrane biogenesis. ..
  19. Tabuchi M, Audhya A, Parsons A, Boone C, Emr S. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol. 2006;26:5861-75 pubmed
    ..Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization. ..
  20. Padilla Lopez S, Langager D, Chan C, Pearce D. BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution. Dis Model Mech. 2012;5:191-9 pubmed publisher
    ..Deletion of both BTN1 and PSD1 (btn1-? psd1-?) led to a further decrease in levels of PtdEtn in ER membranes associated to mitochondria (MAMs), ..
  21. Tavassoli S, Chao J, Young B, Cox R, Prinz W, de Kroon A, et al. Plasma membrane--endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis. EMBO Rep. 2013;14:434-40 pubmed publisher
    ..Opi3 activity requires Osh3, which localizes to PM-ER contacts where it might facilitate in trans catalysis by Opi3. Thus, membrane contact sites provide a structural mechanism to regulate lipid synthesis. ..
  22. Liu Y, Wang X, Chen X. Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases. Mol Biol Cell. 2015;26:1985-94 pubmed publisher
    ..This finding could have broad implications for understanding other dominant diseases (e.g., retinitis pigmentosa) caused by missense mutations in membrane proteins. ..
  23. Miyata N, Miyoshi T, Yamaguchi T, Nakazono T, Tani M, Kuge O. VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae. Biochem J. 2015;472:319-28 pubmed publisher
    ..b>PSD1 null (psd1Δ) and PSD2 null (psd2Δ) mutants are viable in a synthetic minimal medium, but a psd1Δ psd2Î..