PRX1

Summary

Gene Symbol: PRX1
Description: thioredoxin peroxidase PRX1
Alias: thioredoxin peroxidase PRX1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Moon J, Kim G, Kim E, Lee H, Ha B, Lee S, et al. Reversal of 2-Cys peroxiredoxin oligomerization by sulfiredoxin. Biochem Biophys Res Commun. 2013;432:291-5 pubmed publisher
    ..Here we investigated whether Srx1 directly facilitates the dissociation of yeast Prx1 (YPrx1) from a high-molecular-weight (HMW) complex to a low-molecular-weight (LMW) complex in vitro...
  2. Pedrajas J, McDonagh B, Hernández Torres F, Miranda Vizuete A, González Ojeda R, Martínez Galisteo E, et al. Glutathione Is the Resolving Thiol for Thioredoxin Peroxidase Activity of 1-Cys Peroxiredoxin Without Being Consumed During the Catalytic Cycle. Antioxid Redox Signal. 2016;24:115-28 pubmed publisher
    ..Prx1p is fairly well protected from overoxidation, questioning its role in a floodgate mechanism for H2O2 signaling. ..
  3. Lin J, Blackburn E. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev. 2004;18:387-96 pubmed
    ..Hence, we propose that yPinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. ..
  4. McDonagh B, Padilla C, Pedrajas J, Bárcena J. Biosynthetic and iron metabolism is regulated by thiol proteome changes dependent on glutaredoxin-2 and mitochondrial peroxiredoxin-1 in Saccharomyces cerevisiae. J Biol Chem. 2011;286:15565-76 pubmed publisher
    ..Strikingly, requirement of Grx2p for these events places dithiolic Grx2 in the framework of iron metabolism. ..
  5. Monteiro G, Netto L. Glucose repression of PRX1 expression is mediated by Tor1p and Ras2p through inhibition of Msn2/4p in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2004;241:221-8 pubmed
    ..We have previously shown that glucose represses the expression of mitochondrial thioredoxin peroxidase gene (PRX1) in a process mediated by cAMP/protein kinase A (PKA) and Msn2/4p...
  6. Greetham D, Grant C. Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo. Mol Cell Biol. 2009;29:3229-40 pubmed publisher
    ..Here, we show that the yeast mitochondrial 1-Cys Prx1 is reactivated by glutathionylation of the catalytic cysteine residue and subsequent reduction by thioredoxin ..
  7. Park S, Cha M, Jeong W, Kim I. Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae. J Biol Chem. 2000;275:5723-32 pubmed
  8. Roussel X, Béchade G, Kriznik A, Van Dorsselaer A, Sanglier Cianferani S, Branlant G, et al. Evidence for the formation of a covalent thiosulfinate intermediate with peroxiredoxin in the catalytic mechanism of sulfiredoxin. J Biol Chem. 2008;283:22371-82 pubmed publisher
    ..Taken altogether, our results strongly argue in favor of the formation of a covalent thiosulfinate peroxiredoxin-sulfiredoxin species as an intermediate on the catalytic pathway. ..
  9. Wong C, Siu K, Jin D. Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem. 2004;279:23207-13 pubmed
    ..Our findings suggest that the antioxidant function of peroxiredoxins is important for maintaining genome stability in eukaryotic cells. ..

More Information

Publications16

  1. Kaur J, Stuart R. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. EMBO Rep. 2011;12:950-5 pubmed publisher
    ..tunnel-exit-site proteins, an uncharacterized ribosomal protein, MrpL25, and the mitochondrial peroxiredoxin (Prx), Prx1, accumulates in an mrp20?C yeast mutant...
  2. Choi J, Choi S, Chon J, Choi J, Cha M, Kim I, et al. Crystal structure of the C107S/C112S mutant of yeast nuclear 2-Cys peroxiredoxin. Proteins. 2005;61:1146-9 pubmed
  3. Gomes F, Palma F, Barros M, Tsuchida E, Turano H, Alegria T, et al. Proteolytic cleavage by the inner membrane peptidase (IMP) complex or Oct1 peptidase controls the localization of the yeast peroxiredoxin Prx1 to distinct mitochondrial compartments. J Biol Chem. 2017;292:17011-17024 pubmed publisher
    Yeast Prx1 is a mitochondrial 1-Cys peroxiredoxin that catalyzes the reduction of endogenously generated H2O2 Prx1 is synthesized on cytosolic ribosomes as a preprotein with a cleavable N-terminal presequence that is ..
  4. Pedrajas J, Padilla C, McDonagh B, Bárcena J. Glutaredoxin participates in the reduction of peroxides by the mitochondrial 1-CYS peroxiredoxin in Saccharomyces cerevisiae. Antioxid Redox Signal. 2010;13:249-58 pubmed publisher
    ..Saccharomyces cerevisiae Prx1 is a mitochondrial enzyme belonging to the 1-Cys Prx, whereas Grx2 is involved in antioxidant defense and localizes ..
  5. Fomenko D, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, et al. Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A. 2011;108:2729-34 pubmed publisher
    ..The data suggest that thiol peroxidases sense and transfer oxidative signals to the signaling proteins and regulate transcription, whereas a direct interaction between H(2)O(2) and other cellular proteins plays a secondary role. ..
  6. Greetham D, Kritsiligkou P, Watkins R, Carter Z, Parkin J, Grant C. Oxidation of the yeast mitochondrial thioredoxin promotes cell death. Antioxid Redox Signal. 2013;18:376-85 pubmed publisher
    ..Our data also indicate a role for a mitochondrial 1-cysteine (Cys) peroxiredoxin (Prx1) in the oxidation of Trx3, since Trx3 does not become oxidized in glr1 trr2 mutants or in a wild-type strain ..
  7. Pedrajas J, Miranda Vizuete A, Javanmardy N, Gustafsson J, Spyrou G. Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. J Biol Chem. 2000;275:16296-301 pubmed
    ..Finally, exposure of null Prx1p mutant cells to oxidant conditions reveals an important role of the mitochondrial 1-Cys Prx in protection against oxidative stress. ..