Gene Symbol: PRS4
Description: ribose phosphate diphosphokinase subunit PRS4
Alias: ribose phosphate diphosphokinase subunit PRS4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Kimata Y, Higashio H, Kohno K. Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP. J Biol Chem. 2000;275:10655-60 pubmed
    ..Genetic analysis revealed that one of the suppressors is allelic to PRE8 (PRS4), which encodes a 20 S proteasome subunit...
  2. Hernando Y, Carter A, Parr A, Hove Jensen B, Schweizer M. Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem. 1999;274:12480-7 pubmed
    ..into three groups: (i) a lethal phenotype that corresponds to strains containing a double disruption in PRS2 and PRS4 in combination with a disruption in either PRS1 or PRS3; simultaneous deletion of PRS1 and PRS5 or PRS3 and PRS5 ..
  3. Wang K, Vavassori S, Schweizer L, Schweizer M. Impaired PRPP-synthesizing capacity compromises cell integrity signalling in Saccharomyces cerevisiae. Microbiology. 2004;150:3327-39 pubmed
    ..has shown that Prs1, specifically the non-homologous region, NHR1-1 and Prs3, and to a lesser extent Prs2 and Prs4, interact with the MAPK (mitogen-activated protein kinase) of the cell integrity pathway, Slt2...
  4. Hove Jensen B. Heterooligomeric phosphoribosyl diphosphate synthase of Saccharomyces cerevisiae: combinatorial expression of the five PRS genes in Escherichia coli. J Biol Chem. 2004;279:40345-50 pubmed
    ..These combinations were PRS1 PRS2, PRS1 PRS3, and PRS1 PRS4, as well as PRS5 PRS2 and PRS5 PRS4...
  5. Ugbogu E, Wang K, Schweizer L, Schweizer M. Metabolic gene products have evolved to interact with the cell wall integrity pathway in Saccharomyces cerevisiae. FEMS Yeast Res. 2016;16: pubmed
    ..Therefore, the unexpected impairment of the CWI phenotype encountered in yeast strains either mutated or deleted for PRS1 or PRS5 can be explained by disruption of the communication between primary cell metabolism and CWI signalling. ..