PRP31

Summary

Gene Symbol: PRP31
Description: U4/U6-U5 snRNP complex subunit PRP31
Alias: U4/U6-U5 snRNP complex subunit PRP31
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Bouveret E, Rigaut G, Shevchenko A, Wilm M, Seraphin B. A Sm-like protein complex that participates in mRNA degradation. EMBO J. 2000;19:1661-71 pubmed
    ..These results indicate the involvement of a new conserved Sm-like protein complex and a new factor, Pat1p, in mRNA degradation and suggest a physical connection between decapping and exonuclease trimming. ..
  2. Häcker I, Sander B, Golas M, Wolf E, Karagöz E, Kastner B, et al. Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol. 2008;15:1206-12 pubmed publisher
    ..The head and arm adopt variable relative positions. This molecular organization and dynamics suggest possible scenarios for structural events during catalytic activation. ..
  3. Weidenhammer E, Ruiz Noriega M, Woolford J. Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae. Mol Cell Biol. 1997;17:3580-8 pubmed
    The PRP31 gene encodes a factor essential for the splicing of pre-mRNA in Saccharomyces cerevisiae...
  4. Taoka M, Yamauchi Y, Nobe Y, Masaki S, Nakayama H, Ishikawa H, et al. An analytical platform for mass spectrometry-based identification and chemical analysis of RNA in ribonucleoprotein complexes. Nucleic Acids Res. 2009;37:e140 pubmed publisher
  5. Bizarro J, Dodré M, Huttin A, Charpentier B, Schlotter F, Branlant C, et al. NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins. Nucleic Acids Res. 2015;43:8973-89 pubmed publisher
    ..They both contain the 15.5K and proteins with NOP domains (PRP31 for U4, NOP56/58 for snoRNPs)...
  6. Boulon S, Marmier Gourrier N, Pradet Balade B, Wurth L, Verheggen C, Jady B, et al. The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol. 2008;180:579-95 pubmed publisher
    ..Thus, Hsp90 may control the folding of these proteins during the formation of new RNPs. This suggests that Hsp90 functions as a master regulator of cell proliferation by allowing simultaneous control of cell signaling and cell growth. ..