Gene Symbol: PPZ2
Description: salt homeostasis regulator
Alias: salt homeostasis regulator
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Yenush L, Mulet J, Arino J, Serrano R. The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J. 2002;21:920-9 pubmed
    ..In addition to providing a coherent explanation for all Ppz-dependent phenotypes, our results provide evidence for a causal relationship between intracellular cation homeostasis and a potential cell cycle checkpoint. ..
  2. Marquina M, González A, Barreto L, Gelis S, Munoz I, Ruiz A, et al. Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin. Genetics. 2012;190:1355-64 pubmed publisher
    ..These results point to a complex role of Ypi1 on the regulation of cation homeostasis, largely mediated by the calcineurin phosphatase. ..
  3. Aksenova A, Munoz I, Volkov K, Arino J, Mironova L. The HAL3-PPZ1 dependent regulation of nonsense suppression efficiency in yeast and its influence on manifestation of the yeast prion-like determinant [ISP(+)]. Genes Cells. 2007;12:435-45 pubmed
    ..A model considering epigenetic (possibly prion) regulation of Hal3p amount as a mechanism underlying [ISP(+)] status of yeast cell is suggested. ..
  4. Ruiz A, del Carmen Ruiz M, Sánchez Garrido M, Arino J, Ramos J. The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast. FEBS Lett. 2004;578:58-62 pubmed
    ..This can be explained by the observation that trk1 trk2 ppz1 or trk1 trk2 ppz1 ppz2 strains display a very poor rubidium uptake, with markedly increased Km values...
  5. Posas F, Casamayor A, Arino J. The PPZ protein phosphatases are involved in the maintenance of osmotic stability of yeast cells. FEBS Lett. 1993;318:282-6 pubmed
    ..by polymerase chain reaction techniques a genomic fragment of about 600 bp corresponding to this second gene (PPZ2)...
  6. Aghamohammadzadeh S, Ayscough K. Differential requirements for actin during yeast and mammalian endocytosis. Nat Cell Biol. 2009;11:1039-42 pubmed publisher
    ..Conversely, increased turgor pressure in specific yeast mutants correlated with a decreased rate of endocytic patch invagination. ..
  7. Ruiz A, Yenush L, Arino J. Regulation of ENA1 Na(+)-ATPase gene expression by the Ppz1 protein phosphatase is mediated by the calcineurin pathway. Eukaryot Cell. 2003;2:937-48 pubmed
    ..of the ENA1 Na(+)-ATPase gene, a major determinant for sodium extrusion, while cells devoid of the similar Ppz2 protein do not show these phenotypes...
  8. Munoz I, Simon E, Casals N, Clotet J, Arino J. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast. 2003;20:157-69 pubmed
    ..The possible relationship between the known functions of these suppressor genes and the progress through the G(1)-S transition is discussed. ..
  9. Sakumoto N, Matsuoka I, Mukai Y, Ogawa N, Kaneko Y, Harashima S. A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast. 2002;19:587-99 pubmed
    ..In addition to the ptc1, ynr022c and ycr079w single disruptants, the ppz1 ppz2 double disruptant showed temperature-sensitive slow growth...

More Information


  1. Merchan S, Bernal D, Serrano R, Yenush L. Response of the Saccharomyces cerevisiae Mpk1 mitogen-activated protein kinase pathway to increases in internal turgor pressure caused by loss of Ppz protein phosphatases. Eukaryot Cell. 2004;3:100-7 pubmed
    ..Finally, despite its role in G1/S transition, increased levels of activated Mpk1 do not appear to be responsible for the cell cycle phenotype observed in Ppz-deficient strains. ..
  2. Venturi G, Bloecher A, Williams Hart T, Tatchell K. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Genetics. 2000;155:69-83 pubmed
    ..ppz1 ppz2 null mutants have no apparent growth defect on rich media...
  3. Lee K, Hines L, Levin D. A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway. Mol Cell Biol. 1993;13:5843-53 pubmed
    ..One of these genes is identical to the previously identified PPZ2 gene...
  4. Merchan S, Pedelini L, Hueso G, Calzada A, Serrano R, Yenush L. Genetic alterations leading to increases in internal potassium concentrations are detrimental for DNA integrity in Saccharomyces cerevisiae. Genes Cells. 2011;16:152-65 pubmed publisher
    ..Yeast strains lacking the PPZ1 and PPZ2 phosphatase genes, which aberrantly accumulate potassium, are sensitive to agents causing replicative stress or DNA ..
  5. Posas F, Camps M, Arino J. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells. J Biol Chem. 1995;270:13036-41 pubmed
    Protein phosphatases PPZ1 and PPZ2 represent a novel form of Ser/Thr phosphatases structurally related to type 1 phosphatases and characterized by an unusual amino-terminal region...
  6. Makanae K, Kintaka R, Makino T, Kitano H, Moriya H. Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method. Genome Res. 2013;23:300-11 pubmed publisher
    ..The results obtained in this study will provide basic knowledge about the physiology of chromosomal abnormalities and the evolution of chromosomal composition. ..
  7. Cheng Y, Chen R. Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone. J Cell Sci. 2015;128:1180-92 pubmed publisher
    ..Furthermore, Cdc48-Shp1 binds and prevents misfolding of PP1-like phosphatases Ppz2 and Ppq1, but not other types of phosphatases...
  8. Hughes V, Muller A, Stark M, Cohen P. Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress. Eur J Biochem. 1993;216:269-79 pubmed
    The sequences of two genes encoding the protein-serine/threonine-phosphatases PPZ1 and PPZ2 from Saccharomyces cerevisiae have been determined. The molecular masses of PPZ1 and PPZ2 are 77.5 and 78...