Gene Symbol: PPT1
Description: protein serine/threonine phosphatase
Alias: protein serine/threonine phosphatase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Chen M, McPartlin A, Brown L, Chen Y, Barker H, Cohen P. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J. 1994;13:4278-90 pubmed
    ..protein serine/threonine phosphatase, PP5, and a structurally related phosphatase in Saccharomyces cerevisiae, PPT1, have been identified from their cDNA and gene respectively...
  2. Wandinger S, Suhre M, Wegele H, Buchner J. The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90. EMBO J. 2006;25:367-76 pubmed
    b>Ppt1 is the yeast member of a novel family of protein phosphatases, which is characterized by the presence of a tetratricopeptide repeat (TPR) domain...
  3. Jeong J, Johns J, Sinclair C, Park J, Rossie S. Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5. BMC Cell Biol. 2003;4:3 pubmed
    ..Ppt1p was localized throughout the cell including the nucleus. Levels of PPT1 mRNA and protein peaked in early log phase growth...
  4. Vaughan C, Mollapour M, Smith J, Truman A, Hu B, Good V, et al. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell. 2008;31:886-95 pubmed publisher
    ..nonspecific phosphatases, it is efficiently dephosphorylated by the chaperone-targeted protein phosphatase 5 (PP5/Ppt1), which does not affect isolated Cdc37...
  5. Cho B, Lee P, Hahn J. CK2-dependent inhibitory phosphorylation is relieved by Ppt1 phosphatase for the ethanol stress-specific activation of Hsf1 in Saccharomyces cerevisiae. Mol Microbiol. 2014;93:306-16 pubmed publisher
    ..This repression is relieved by dephosphorylation by Ppt1 which directly interacts with Hsf1 via its tetratricopeptide repeat (TPR) domain...
  6. Johnson J, Zuehlke A, Tenge V, Langworthy J. Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones. Curr Genet. 2014;60:265-76 pubmed publisher
    ..However, overexpression of SBA1, PPT1, AHA1 or HCH1 caused varying levels of growth defects in an sgt1-K360E strain...
  7. Mayordomo I, Sanz P. The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein. Biochem J. 2002;365:51-6 pubmed
    ..involved in transcriptional regulation such as Mbf1, Gcr2 and Reg2, and a variety of other different proteins (Ppt1, Lre1, Rps0A and Ylr177w)...
  8. Noguchi C, Watanabe D, Zhou Y, Akao T, Shimoi H. Association of constitutive hyperphosphorylation of Hsf1p with a defective ethanol stress response in Saccharomyces cerevisiae sake yeast strains. Appl Environ Microbiol. 2012;78:385-92 pubmed publisher
    ..Among the 29 mutants, a ?ppt1 mutant exhibited constitutive hyperphosphorylation of Hsf1p, similarly to the modern sake yeast strains, which lack ..
  9. Zuehlke A, Johnson J. Chaperoning the chaperone: a role for the co-chaperone Cpr7 in modulating Hsp90 function in Saccharomyces cerevisiae. Genetics. 2012;191:805-14 pubmed publisher