Gene Symbol: PMP3
Alias: SNA1, Pmp3p
Species: Saccharomyces cerevisiae S288c
Navarre C, Goffeau A. Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane. EMBO J. 2000;19:2515-24 pubmed
Yeast plasma membranes contain a small 55 amino acid hydrophobic polypeptide, Pmp3p, which has high sequence similarity to a novel family of plant polypeptides that are overexpressed under high salt concentration or low temperature ..
Erez O, Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun. 2002;295:1142-9 pubmed
..We show that Sky1p and Pmp3p act in different pathways...
Huang Z, Chen K, Zhang J, Li Y, Wang H, Cui D, et al
. A functional variomics tool for discovering drug-resistance genes and drug targets. Cell Rep. 2013;3:577-85 pubmed publisher
..With amphotericin B, we discovered the highly conserved membrane protein Pmp3 as a potent resistance factor and a possible target...
Bari V, Sharma S, Alfatah M, Mondal A, Ganesan K. Plasma Membrane Proteolipid 3 Protein Modulates Amphotericin B Resistance through Sphingolipid Biosynthetic Pathway. Sci Rep. 2015;5:9685 pubmed publisher
..In contrast, depletion of sphingolipids sensitizes cells to AmB. Recently, overexpression of PMP3 gene, encoding plasma membrane proteolipid 3 protein, was shown to increase and its deletion to decrease, AmB ..
De Block J, Szopinska A, Guerriat B, Dodzian J, Villers J, Hochstenbach J, et al
. Yeast Pmp3p has an important role in plasma membrane organization. J Cell Sci. 2015;128:3646-59 pubmed publisher
b>Pmp3p-related proteins are highly conserved proteins that exist in bacteria, yeast, nematodes and plants, and its transcript is regulated in response to abiotic stresses, such as low temperature or high salinity...