Gene Symbol: PMI40
Description: mannose-6-phosphate isomerase PMI40
Alias: mannose-6-phosphate isomerase PMI40
Species: Saccharomyces cerevisiae S288c
Smith D, Proudfoot A, Friedli L, Klig L, Paravicini G, Payton M. PMI40, an intron-containing gene required for early steps in yeast mannosylation. Mol Cell Biol. 1992;12:2924-30 pubmed
We have previously described a temperature-sensitive pmi40-1 mutant of Saccharomyces cerevisiae which is defective in glycosylation and secretion because of a thermolabile phosphomannose isomerase (PMI) activity...
Wells T, Payton M, Proudfoot A. Inhibition of phosphomannose isomerase by mercury ions. Biochemistry. 1994;33:7641-6 pubmed
..In the Escherichia coli enzyme this cysteine is replaced by an asparagine, and the enzyme cannot be irreversibly inactivated by mercury ions.(ABSTRACT TRUNCATED AT 250 WORDS) ..
Cullen P, Schultz J, Horecka J, Stevenson B, Jigami Y, Sprague G. Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast. Genetics. 2000;155:1005-18 pubmed
..Partial loss-of-function alleles of PGI1, PMI40, PSA1, DPM1, ALG1, MNN10, SPT14, and OCH1, genes required for mannose utilization and protein glycosylation, ..
Pitkänen J, Törmä A, Alff S, Huopaniemi L, Mattila P, Renkonen R. Excess mannose limits the growth of phosphomannose isomerase PMI40 deletion strain of Saccharomyces cerevisiae. J Biol Chem. 2004;279:55737-43 pubmed
Phosphomannose isomerase (PMI40) catalyzes the conversion between fructose 6-phosphate and mannose 6-phosphate and thus connects glycolysis, i.e...
Adhikari H, Vadaie N, Chow J, Caccamise L, Chavel C, Li B, et al
. Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway. Mol Cell Biol. 2015;35:1414-32 pubmed publisher
..We speculate that the QC pathways broadly regulate signaling glycoproteins and their cognate pathways by recognizing altered glycosylation patterns that can occur in response to extrinsic cues. ..