PLB1

Summary

Gene Symbol: PLB1
Description: lysophospholipase
Alias: lysophospholipase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Johnson D, Knoll L, Levin D, Gordon J. Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N-myristoylation and cellular lipid metabolism. J Cell Biol. 1994;127:751-62 pubmed
    ..pool appears to be derived in part from membrane phospholipids since overexpression of Plb1p, a nonessential lysophospholipase/phospholipase B, suppresses the temperature-sensitive growth arrest and C14:0 auxotrophy produced by nmt1-..
  2. De Smet C, Cox R, Brouwers J, de Kroon A. Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p. Biochim Biophys Acta. 2013;1831:1167-76 pubmed publisher
    ..The results indicate that PC serves as a buffer for excess cellular C16:0. ..
  3. Surlow B, Cooley B, Needham P, Brodsky J, Patton Vogt J. Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. J Biol Chem. 2014;289:31591-604 pubmed publisher
    ..Deletion of PLB1, a gene encoding a B-type phospholipase that hydrolyzes PC, in a ypk1Δ mutant curtails the increased PC ..
  4. Lee K, Patton J, Fido M, Hines L, Kohlwein S, Paltauf F, et al. The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity. J Biol Chem. 1994;269:19725-30 pubmed
    Several enzymes with lysophospholipase/phospholipase B activity have been described from the budding yeast Saccharomyces cerevisiae...
  5. Fyrst H, Oskouian B, Kuypers F, Saba J. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Biochemistry. 1999;38:5864-71 pubmed
    The PLB1 gene of Saccharomyces cerevisiae encodes a protein that demonstrates phospholipase B, lysophospholipase, and transacylase activities. Several genes with significant homology to PLB1 exist in the S...
  6. Roelants F, Torrance P, Bezman N, Thorner J. Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell. 2002;13:3005-28 pubmed
    ..Thus, Pkh1-Ypk1 and Pkh2-Ykr2 function in a novel pathway for cell wall integrity that acts in parallel with the Pkc1-dependent pathway. ..
  7. Shia W, Osada S, Florens L, Swanson S, Washburn M, Workman J. Characterization of the yeast trimeric-SAS acetyltransferase complex. J Biol Chem. 2005;280:11987-94 pubmed
    ..This specific lysine preference corresponds to the role of SAS complex in antagonizing the spreading of Sir proteins at silent loci in S. cerevisiae. ..
  8. Merkel O, Fido M, Mayr J, Prüger H, Raab F, Zandonella G, et al. Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae. J Biol Chem. 1999;274:28121-7 pubmed
    ..as PLB2 and PLB3, that are 67% and 62% identical, respectively, to PLB1, which codes for a phospholipase B/lysophospholipase in yeast (Lee, S. K., Patton, J. L., Fido, M., Hines, L. K., Kohlwein, S. D., Paltauf, F., Henry, S. A...
  9. Tamaki H, Shimada A, Ito Y, Ohya M, Takase J, Miyashita M, et al. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. J Biol Chem. 2007;282:34288-98 pubmed
    ..These results indicate that, in concert with Slc1, Lpt1 plays a central role in PA biosynthesis, which is essential for cell viability. ..