Gene Symbol: PIC2
Description: Cu/Pi carrier
Alias: Cu/Pi carrier
Species: Saccharomyces cerevisiae S288c
Hamel P, Saint Georges Y, de Pinto B, Lachacinski N, Altamura N, Dujardin G. Redundancy in the function of mitochondrial phosphate transport in Saccharomyces cerevisiae and Arabidopsis thaliana. Mol Microbiol. 2004;51:307-17 pubmed
..We have called this gene PIC2 for Pi carrier isoform 2...
Yamano K, Ishikawa D, Esaki M, Endo T. The phosphate carrier has an ability to be sorted to either the TIM22 pathway or the TIM23 pathway for its import into yeast mitochondria. J Biol Chem. 2005;280:10011-7 pubmed
..PiC thus appears to have a latent signal for sorting to the TIM23 pathway, which is exposed by reduced interactions with the Tim9-Tim10 complex and maintenance of the import competence. ..
Zotova L, Aleschko M, Sponder G, Baumgartner R, Reipert S, Prinz M, et al
. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010;285:14399-414 pubmed publisher
..on nonfermentable substrate) phenotype of mdm38Delta mutants, we now characterized the mitochondrial carriers PIC2 and MRS3 as moderate suppressors and MRS7 and YDL183c as strong suppressors...
Okamoto H, Miyagawa A, Shiota T, Tamura Y, Endo T. Intramolecular disulfide bond of Tim22 protein maintains integrity of the TIM22 complex in the mitochondrial inner membrane. J Biol Chem. 2014;289:4827-38 pubmed publisher
..Our findings provide a new insight into the mechanism of the maintenance of the structural and functional integrity of the TIM22 complex. ..
Ghosh A, Pratt A, Soma S, Theriault S, Griffin A, Trivedi P, et al
. Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis. Hum Mol Genet. 2016;25:660-71 pubmed publisher
..Taken together, these results place COA6 in the copper delivery pathway to CcO and, surprisingly, link it to a previously unidentified function of CcO subunit Cox12 in Cox2 biogenesis. ..
Vest K, Leary S, Winge D, Cobine P. Copper import into the mitochondrial matrix in Saccharomyces cerevisiae is mediated by Pic2, a mitochondrial carrier family protein. J Biol Chem. 2013;288:23884-92 pubmed publisher
..Strains with a deletion of PIC2 grew poorly on copper-deficient non-fermentable medium supplemented with silver and under respiratory conditions ..
Vest K, Wang J, Gammon M, Maynard M, White O, Cobine J, et al
. Overlap of copper and iron uptake systems in mitochondria in Saccharomyces cerevisiae. Open Biol. 2016;6:150223 pubmed publisher
In Saccharomyces cerevisiae, the mitochondrial carrier family protein Pic2 imports copper into the matrix...