PHO87

Summary

Gene Symbol: PHO87
Description: SPX domain-containing inorganic phosphate transporter
Alias: SPX domain-containing inorganic phosphate transporter
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Wykoff D, O Shea E. Phosphate transport and sensing in Saccharomyces cerevisiae. Genetics. 2001;159:1491-9 pubmed
    ..Finally, a PHO84-dependent compensation response was identified; the abundance of Pho84p at the plasma membrane increases in cells that are defective in other phosphate transporters. ..
  2. Auesukaree C, Homma T, Kaneko Y, Harashima S. Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2003;306:843-50 pubmed
    ..In contrast to that of PHO5, PHO84, and PHO89, the transcription of PHO87, PHO90, and PHO91 genes is independent of P(i) concentration and Pho4p activity, and the increased expression ..
  3. Hürlimann H, Stadler Waibel M, Werner T, Freimoser F. Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2007;18:4438-45 pubmed
    ..poly P content as a read-out, it was possible to define novel functions of the five phosphate transporters: Pho84, Pho87, Pho89, Pho90, and Pho91, in budding yeast...
  4. Auesukaree C, Fuchigami I, Homma T, Kaneko Y, Harashima S. Ddi1p and Rad23p play a cooperative role as negative regulators in the PHO pathway in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2008;365:821-5 pubmed
    ..4mM, suggesting that Ddi1p and Rad23p play a cooperative role as negative regulators in the PHO pathway. ..
  5. Ghillebert R, Swinnen E, De Snijder P, Smets B, Winderickx J. Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae. Biochem J. 2011;434:243-51 pubmed publisher
    ..In contrast, transcription of PHO87 and PHO90, encoding the low-affinity H(+)/P(i) transport system, is independent of phosphate status...
  6. Yompakdee C, Bun Ya M, Shikata K, Ogawa N, Harashima S, Oshima Y. A putative new membrane protein, Pho86p, in the inorganic phosphate uptake system of Saccharomyces cerevisiae. Gene. 1996;171:41-7 pubmed
    ..The other three genes, GTR1, PHO86 and PHO87, are also suggested to be involved in the P(i) uptake system...
  7. Hürlimann H, Pinson B, Stadler Waibel M, Zeeman S, Freimoser F. The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity. EMBO Rep. 2009;10:1003-8 pubmed publisher
    ..each other: the high-affinity transporters (Pho84 and Pho89) are active under phosphate starvation, whereas Pho87 and Pho90 are low-affinity transporters that function when phosphate is abundant...
  8. Bun Ya M, Shikata K, Nakade S, Yompakdee C, Harashima S, Oshima Y. Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae. Curr Genet. 1996;29:344-51 pubmed
    ..5 mM arsenate. This mutant has double mutations designated as pho86 and pho87. The mutant transcribes PHO84 even in the repressible condition but has a severe defect in Pi uptake...
  9. Yompakdee C, Ogawa N, Harashima S, Oshima Y. A putative membrane protein, Pho88p, involved in inorganic phosphate transport in Saccharomyces cerevisiae. Mol Gen Genet. 1996;251:580-90 pubmed
    ..Both disruption and high dosage of PHO88 or PHO86 resulted in reduced Pi uptake. These findings suggest that Pho88p is also involved in Pi transport and modulates Pho81p function together with Pho86p. ..

More Information

Publications11

  1. Estrella L, Krishnamurthy S, Timme C, Hampsey M. The Rsp5 E3 ligase mediates turnover of low affinity phosphate transporters in Saccharomyces cerevisiae. J Biol Chem. 2008;283:5327-34 pubmed publisher
    ..Western blot analyses revealed that the cellular levels of the Pho87 and Pho91 low affinity P i are markedly increased in the spa1-1 mutant, yet Pho84 high affinity P i transporter ..
  2. Lazard M, Blanquet S, Fisicaro P, Labarraque G, Plateau P. Uptake of selenite by Saccharomyces cerevisiae involves the high and low affinity orthophosphate transporters. J Biol Chem. 2010;285:32029-37 pubmed publisher
    ..The properties of phosphate and selenite transport enable us to propose an explanation to the paradoxical increase of selenite toxicity when phosphate concentration in the growth medium is raised above 1 mm. ..