Gene Symbol: PHB1
Description: prohibitin subunit PHB1
Alias: prohibitin subunit PHB1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Back J, Sanz M, De Jong L, de Koning L, Nijtmans L, de Koster C, et al. A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry. Protein Sci. 2002;11:2471-8 pubmed
    The mitochondrial prohibitin complex consists of two subunits (PHB1 of 32 kD and PHB2 of 34 kD), assembled into a membrane-associated supercomplex of approximately 1 MD...
  2. Bayot A, Gareil M, Rogowska Wrzesinska A, Roepstorff P, Friguet B, Bulteau A. Identification of novel oxidized protein substrates and physiological partners of the mitochondrial ATP-dependent Lon-like protease Pim1. J Biol Chem. 2010;285:11445-57 pubmed publisher
    ..The results presented here supply evidence that Pim1-mediated proteolysis is required for elimination of oxidatively damaged proteins in mitochondria...
  3. Harner M, Korner C, Walther D, Mokranjac D, Kaesmacher J, Welsch U, et al. The mitochondrial contact site complex, a determinant of mitochondrial architecture. EMBO J. 2011;30:4356-70 pubmed publisher
    ..Loss of MICOS subunits results in loss of respiratory competence and altered inheritance of mitochondrial DNA. ..
  4. Birner R, Nebauer R, Schneiter R, Daum G. Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine biosynthetic machinery with the prohibitin complex of Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:370-83 pubmed
    ..This screen unveiled mutations in PHB1 and PHB2 encoding the two subunits of the prohibitin complex, which is located to the IMM and required for the ..
  5. Nolden M, Ehses S, Koppen M, Bernacchia A, Rugarli E, Langer T. The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria. Cell. 2005;123:277-89 pubmed
    ..Our findings therefore rationalize mitochondrial defects associated with m-AAA protease mutants in yeast and shed new light on the mechanism of axonal degeneration in HSP. ..
  6. Steglich G, Neupert W, Langer T. Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondria. Mol Cell Biol. 1999;19:3435-42 pubmed
    ..The m-AAA protease is composed of the homologous subunits Yta10p (Afg3p) and Yta12p (Rca1p). Deletion of PHB1 or PHB2 impairs growth of Deltayta10 or Deltayta12 cells but does not affect cell growth in the presence of the m-..
  7. Nijtmans L, de Jong L, Artal Sanz M, Coates P, Berden J, Back J, et al. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J. 2000;19:2444-51 pubmed
    ..Pulse-chase experiments with mitochondria isolated from phb1/phb2-null and PHB1/2 overexpressing cells show that the Phb1/2 complex is able to stabilize newly synthesized ..
  8. Potting C, Wilmes C, Engmann T, Osman C, Langer T. Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. 2010;29:2888-98 pubmed publisher
    ..Homologues to all components of this pathway are present in higher eukaryotes, suggesting that the regulation of mitochondrial CL and PE levels is conserved in evolution. ..
  9. Tatsuta T, Model K, Langer T. Formation of membrane-bound ring complexes by prohibitins in mitochondria. Mol Biol Cell. 2005;16:248-59 pubmed
    ..Two prohibitin homologues, Phb1 and Phb2, assemble into a high molecular weight complex of approximately 1...

More Information


  1. Osman C, Wilmes C, Tatsuta T, Langer T. Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase. Mol Biol Cell. 2007;18:627-35 pubmed
    ..Our results therefore characterize not only a novel processing peptidase with chaperone activity in the mitochondrial intermembrane space but also link the function of prohibitins to the F(1)F(O)-ATP synthase complex. ..
  2. Wang X, Zuo X, Kucejova B, Chen X. Reduced cytosolic protein synthesis suppresses mitochondrial degeneration. Nat Cell Biol. 2008;10:1090-7 pubmed
    ..Our finding thus establishes a link between protein homeostasis (proteostasis), cellular bioenergetics and mitochondrial maintenance during ageing. ..
  3. Berger K, Yaffe M. Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol. 1998;18:4043-52 pubmed
    ..In otherwise wild-type genetic backgrounds, null mutations in PHB1 and PHB2 did not confer any obvious phenotypes...
  4. Phan V, Ding V, Li F, Chalkley R, Burlingame A, McCormick F. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol. 2010;30:2264-79 pubmed publisher
    ..These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans). ..
  5. Kornmann B, Currie E, Collins S, Schuldiner M, Nunnari J, Weissman J, et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009;325:477-81 pubmed publisher
    ..The tethering complex localized to discrete foci, suggesting that discrete sites of close apposition between ER and mitochondria facilitate interorganelle calcium and phospholipid exchange. ..
  6. Kirchman P, Miceli M, West R, Jiang J, Kim S, Jazwinski S. Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging. Acta Biochim Pol. 2003;50:1039-56 pubmed
    ..This deleterious effect was suppressed by the deletion of the RAS2 gene. The expression of PHB1 and PHB2 declined gradually up to 5-fold during the life span...
  7. Coates P, Jamieson D, Smart K, Prescott A, Hall P. The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr Biol. 1997;7:607-10 pubmed
    ..Another gene postulated to effect senescence is PHB1, the yeast homologue of prohibitin [3], a rodent gene initially identified as a potential regulator of growth ..
  8. Piper P, Jones G, Bringloe D, Harris N, MacLean M, Mollapour M. The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells. Aging Cell. 2002;1:149-57 pubmed
    ..The prohibitins of Saccharomyces cerevisiae, Phb1 and Phb2, have strong sequence similarity with their human counterparts prohibitin and BAP37, making yeast a good ..
  9. Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher