Gene Symbol: PGI1
Description: glucose-6-phosphate isomerase
Alias: CDC30, glucose-6-phosphate isomerase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Aguilera A, Zimmermann F. Isolation and molecular analysis of the phosphoglucose isomerase structural gene of Saccharomyces cerevisiae. Mol Gen Genet. 1986;202:83-9 pubmed
    The PGI1 gene of Saccharomyces cerevisiae coding for the glycolytic enzyme phosphoglucose isomerase has been cloned by complementation of a mutant strain (pgi1) with a strongly reduced phosphoglucose isomerase activity...
  2. Bhat P, Oh D, Hopper J. Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae. Genetics. 1990;125:281-91 pubmed
    ..We constructed isogenic haploid strains bearing the gal3 mutation in combination with either gal15 or pgi1 mutations: the gal15 and pgi1 blocks are not specific for the galactose pathway in contrast to the gal1, gal7 and ..
  3. Boles E, Lehnert W, Zimmermann F. The role of the NAD-dependent glutamate dehydrogenase in restoring growth on glucose of a Saccharomyces cerevisiae phosphoglucose isomerase mutant. Eur J Biochem. 1993;217:469-77 pubmed
    Phosphoglucose isomerase pgi1-deletion mutants of Saccharomyces cerevisiae cannot grow on glucose as the sole carbon source and are even inhibited by glucose...
  4. Brandina I, Graham J, Lemaitre Guillier C, Entelis N, Krasheninnikov I, Sweetlove L, et al. Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim Biophys Acta. 2006;1757:1217-28 pubmed
    ..This suggests an unsuspected novel function for this complex in tRNA mitochondrial import. ..
  5. Heux S, Cadiere A, Dequin S. Glucose utilization of strains lacking PGI1 and expressing a transhydrogenase suggests differences in the pentose phosphate capacity among Saccharomyces cerevisiae strains. FEMS Yeast Res. 2008;8:217-24 pubmed
    Saccharomyces cerevisiae strains lacking phosphoglucose isomerase (pgi1) cannot use the pentose phosphate (PP) pathway to oxidize glucose, which has been explained by the lack of mechanism for reoxidation of the NADPH surplus...
  6. Araiza Olivera D, Chiquete Felix N, Rosas Lemus M, Sampedro J, Pena A, Mújica A, et al. A glycolytic metabolon in Saccharomyces cerevisiae is stabilized by F-actin. FEBS J. 2013;280:3887-905 pubmed publisher
    ..In S. cerevisiae, a glycolytic metabolon appear to assemble in association with F-actin. In this complex, fermentation activity is enhanced and enzymes are partially protected against inhibition by trehalose or by antibodies. ..
  7. Aguilera A. Deletion of the phosphoglucose isomerase structural gene makes growth and sporulation glucose dependent in Saccharomyces cerevisiae. Mol Gen Genet. 1986;204:310-6 pubmed
    The structural gene PGI1 coding for phosphoglucose isomerase was replaced by the LEU2 gene in the genome of Saccharomyces cerevisiae...
  8. Boles E, Heinisch J, Zimmermann F. Different signals control the activation of glycolysis in the yeast Saccharomyces cerevisiae. Yeast. 1993;9:761-70 pubmed
    ..On the other hand, induction of pyruvate decarboxylase depends mainly on a signal in the lower part of glycolysis. ..
  9. Kus B, Gajadhar A, Stanger K, Cho R, Sun W, Rouleau N, et al. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. J Biol Chem. 2005;280:29470-8 pubmed
    ..The combination of this sensitive assay and the availability of purified substrates will enable the identification of substrates for any purified E3 enzyme. ..

More Information


  1. van Roermund C, IJlst L, Majczak W, Waterham H, Folkerts H, Wanders R, et al. Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae. J Biol Chem. 2012;287:20144-53 pubmed publisher
    ..Importantly, the Pxa1p-Pxa2p complex shares this molecular mechanism with HsABCD1 and HsABCD2...