Gene Symbol: PEX25
Description: Pex25p
Alias: Pex25p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Smith J, Marelli M, Christmas R, Vizeacoumar F, Dilworth D, Ideker T, et al. Transcriptome profiling to identify genes involved in peroxisome assembly and function. J Cell Biol. 2002;158:259-71 pubmed
    ..Ypl112p, renamed Pex25p, is a novel peroxin required for the regulation of peroxisome size and maintenance...
  2. Marelli M, Smith J, Jung S, Yi E, Nesvizhskii A, Christmas R, et al. Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane. J Cell Biol. 2004;167:1099-112 pubmed peroxisomes upon their induction in a process dependent on its interaction with the peroxisome membrane protein Pex25p. Rho1p regulates the assembly state of actin on the peroxisome membrane, thereby controlling peroxisome membrane ..
  3. Vizeacoumar F, Torres Guzman J, Tam Y, Aitchison J, Rachubinski R. YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae. J Cell Biol. 2003;161:321-32 pubmed
    ..Together, our data suggest a role for Yhr150p and Ydr479p, together with Pex25p and Vps1p, in regulating peroxisome number, size, and distribution in S. cerevisiae...
  4. Tam Y, Torres Guzman J, Vizeacoumar F, Smith J, Marelli M, Aitchison J, et al. Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:4089-102 pubmed
    Transcriptome profiling identified the gene PEX25 encoding Pex25p, a peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance in Saccharomyces cerevisiae...
  5. Rottensteiner H, Stein K, Sonnenhol E, Erdmann R. Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis. Mol Biol Cell. 2003;14:4316-28 pubmed
    We describe the isolation and characterization of a homologous pair of proteins, Pex25p (YPL112c) and Pex27p (YOR193w), whose C-termini are similar to the entire Pex11p...
  6. Fagarasanu M, Fagarasanu A, Tam Y, Aitchison J, Rachubinski R. Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae. J Cell Biol. 2005;169:765-75 pubmed
    ..The levels of Inp1p vary with the cell cycle. Inp1p binds Pex25p, Pex30p, and Vps1p, which have been implicated in controlling peroxisome division...
  7. Orth T, Reumann S, Zhang X, Fan J, Wenzel D, Quan S, et al. The PEROXIN11 protein family controls peroxisome proliferation in Arabidopsis. Plant Cell. 2007;19:333-50 pubmed
  8. Koch J, Pranjic K, Huber A, Ellinger A, Hartig A, Kragler F, et al. PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance. J Cell Sci. 2010;123:3389-400 pubmed publisher
    ..Hence, we propose a model for a conserved role of PEX11 proteins in peroxisome maintenance through peroxisome polarization, membrane elongation and segregation. ..
  9. Rottensteiner H, Kramer A, Lorenzen S, Stein K, Landgraf C, Volkmer Engert R, et al. Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals. Mol Biol Cell. 2004;15:3406-17 pubmed
    ..By adding the heterologous binding site of Pex11p, peroxisomal targeting of the Pex13p fragment was restored. We conclude that Pex19p-binding sites are well-defined entities that represent an essential part of the mPTS. ..

More Information


  1. Rucktäschel R, Thoms S, Sidorovitch V, Halbach A, Pechlivanis M, Volkmer R, et al. Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis. J Biol Chem. 2009;284:20885-96 pubmed publisher
    ..Thus, isoprenylation of Pex19p contributes to substrate membrane protein recognition for the topogenesis of PMPs, and our results highlight the importance of lipid modifications in protein-protein interactions. ..
  2. Tower R, Fagarasanu A, Aitchison J, Rachubinski R. The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast. Mol Biol Cell. 2011;22:1727-38 pubmed publisher
    ..membrane protein that acts independently and also in concert with the Pex11 protein family members Pex11p, Pex25p, and Pex27p to control the peroxisome populations of cells under conditions of both peroxisome proliferation and ..
  3. Huber A, Koch J, Kragler F, Brocard C, Hartig A. A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes. Traffic. 2012;13:157-67 pubmed publisher
    ..In the yeast Saccharomyces cerevisiae, the Pex11 family consists of three proteins, Pex11p, Pex25p and Pex27p...
  4. Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher
    ..More importantly, we identified new transient interaction partners (Pex25p, Hrr25p, Esl2p, prohibitin) that provide a valuable resource for future investigations on the functionality, ..
  5. Wróblewska J, Cruz Zaragoza L, Yuan W, Schummer A, Chuartzman S, de Boer R, et al. Saccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins. Biochim Biophys Acta Mol Cell Res. 2017;1864:1656-1667 pubmed publisher
    ..organizing peroxin Pex8, the ubiquitin conjugating enzyme Pex4 with its recruiting PMP Pex22, as well as Pex15 and Pex25 co-localize with Pex14...