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Genomes and Genes | PEX11SummaryGene Symbol: PEX11 Description: Pex11p Alias: PMP24, PMP27 Species: Saccharomyces cerevisiae S288c Top Publications
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Publications
Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27pR Erdmann
Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York 10021
J Cell Biol 128:509-23. 1995..The most abundant of these, Pmp27p, was purified and the corresponding gene PMP27 was cloned and sequenced...- Pmp27 promotes peroxisomal proliferationP A Marshall
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
J Cell Biol 129:345-55. 1995..We have identified a protein, Pmp27, that promotes peroxisomal proliferation. This protein, previously termed Pmp24, was purified from peroxisomal membranes, and the corresponding gene, PMP27, was isolated and sequenced... - Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal divisionP A Marshall
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
J Cell Biol 135:123-37. 1996Pex11p (formerly Pmp27) has been implicated in peroxisomal proliferation (Erdmann, R., and G. Blobel. 1995. J. Cell Biol. 128; 509-523; Marshall, P.A., Y.I. Krimkevich, R.H. Lark, J.M. Dyer, M. Veenhuis, and J.M. Goodman, 1995. J... - Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiaeYuen Yi C Tam
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
Mol Biol Cell 14:4089-102. 2003..are greatly enlarged in cells harboring double deletions of the YOR193w and PEX25 genes, the YOR193w and PEX11 genes, and the PEX25 and PEX11 genes... - The PEROXIN11 protein family controls peroxisome proliferation in ArabidopsisTravis Orth
Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
Plant Cell 19:333-50. 2007PEROXIN11 (PEX11) is a peroxisomal membrane protein in fungi and mammals and was proposed to play a major role in peroxisome proliferation... - Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesisHanspeter Rottensteiner
Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
Mol Biol Cell 14:4316-28. 2003..on fatty acids of a pex25delta mutant was not exacerbated by the additional deletion of PEX27; however, when PEX11 was deleted on top of that, growth was abolished on all fatty acids... - Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomesW Girzalsky
Freie Universitat Berlin, Institut fur Biochemie, 12203 Berlin, Germany
J Cell Biol 144:1151-62. 1999..We also found Pex13p to be required for peroxisomal association of Pex14p, yet the SH3 domain of Pex13p may not provide the only binding site for Pex14p at the peroxisomal membrane... 
Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysisSilke Oeljeklaus
Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany
J Proteome Res 11:2567-80. 2012....- Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomesAdabella van der Zand
Cellular Protein Chemistry, Faculty of Science, Utrecht University, NL 3584 CH Utrecht, The Netherlands
Cell 149:397-409. 2012..Our findings demonstrate a remarkable mechanism to maintain biochemical identity of organelles by transporting crucial components via different routes to their final destination... - Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesisRobert Rucktäschel
Department for Systems Biochemistry, Institute for Physiological Chemistry, University of Bochum, Universitatsstrasse 150, 44780 Bochum
J Biol Chem 284:20885-96. 2009..Thus, isoprenylation of Pex19p contributes to substrate membrane protein recognition for the topogenesis of PMPs, and our results highlight the importance of lipid modifications in protein-protein interactions... - Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signalsHanspeter Rottensteiner
Institut fur Physiologische Chemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
Mol Biol Cell 15:3406-17. 2004..By adding the heterologous binding site of Pex11p, peroxisomal targeting of the Pex13p fragment was restored. We conclude that Pex19p-binding sites are well-defined entities that represent an essential part of the mPTS... - Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiaeC W van Roermund
Department of Clinical Chemistry, Emma Children s Hospital, University of Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
J Cell Biol 150:489-98. 2000..protein Pex11p has previously been implicated in peroxisome proliferation based on morphological observations of PEX11 mutant cells... - A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomesAnja Huber
University of Vienna, Max F Perutz Laboratories, Center for Molecular Biology, Department of Biochemistry and Cell Biology, Dr Bohr Gasse 9, Vienna, Austria
Traffic 13:157-67. 2012..Among the proteins involved in the biogenesis of peroxisomes, peroxins, members of the Pex11 protein family participate in peroxisomal membrane alterations... - The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeastRobert J Tower
Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada Institute for Systems Biology, Seattle, WA 98103, USA
Mol Biol Cell 22:1727-38. 2011..proteins and a specialized divisional machinery that includes peroxisome-specific factors, such as members of the Pex11 protein family, and general organelle divisional factors, such as the dynamin-related protein Vps1p... - Phosphorylation-dependent activation of peroxisome proliferator protein PEX11 controls peroxisome abundanceBarbara Knoblach
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 285:6670-80. 2010..the production of Pex11p in yeast is tightly linked to peroxisome biogenesis by transcriptional regulation of the PEX11 gene, it remains unclear if and how Pex11p activity could be modulated by rapid signaling... - Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membraneMarcello Marelli
Institute for Systems Biology, Seattle, WA 98103, USA
J Cell Biol 167:1099-112. 2004..Rho1p regulates the assembly state of actin on the peroxisome membrane, thereby controlling peroxisome membrane dynamics and biogenesis... 
Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signalsFranco J Vizeacoumar
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 281:14805-12. 2006....- The dynamin-like protein Vps1p of the yeast Saccharomyces cerevisiae associates with peroxisomes in a Pex19p-dependent mannerFranco J Vizeacoumar
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 281:12817-23. 2006..Our results are consistent with Pex19p acting as a chaperone to stabilize the association of Vps1p with peroxisomes and not as a receptor involved in targeting Vps1p to peroxisomes... - Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosolHarald W Platta
Institut fur Physiologische Chemie, Abt Systembiochemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
Nat Cell Biol 7:817-22. 2005..Here we demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol... - Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisomeJörg H Eckert
Ruhr Universitat Bochum, Institut fur Physiologische Chemie, Medizinische Fakultat, 44780 Bochum, Germany
J Cell Sci 116:3623-34. 2003..A yeast strain harboring a deletion of PEX3 enabled us to estimate the influence of the peroxisomal membrane on the formation of a subset of the investigated protein-protein interactions... - PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferationXiaoling Li
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Cell Biol 22:8226-40. 2002The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes. As part of our effort to understand the molecular and physiological functions of PEX11 proteins, we disrupted the mouse PEX11alpha gene... - PEX11 promotes peroxisome division independently of peroxisome metabolismXiaoling Li
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Cell Biol 156:643-51. 2002The PEX11 peroxisomal membrane proteins are the only factors known to promote peroxisome division in multiple species...