PEX11

Summary

Gene Symbol: PEX11
Description: Pex11p
Alias: PMP24, PMP27
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. pmc Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p
    R Erdmann
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York 10021
    J Cell Biol 128:509-23. 1995
  2. pmc Pmp27 promotes peroxisomal proliferation
    P A Marshall
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
    J Cell Biol 129:345-55. 1995
  3. pmc Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division
    P A Marshall
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
    J Cell Biol 135:123-37. 1996
  4. pmc Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae
    Yuen Yi C Tam
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Mol Biol Cell 14:4089-102. 2003
  5. pmc The PEROXIN11 protein family controls peroxisome proliferation in Arabidopsis
    Travis Orth
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 19:333-50. 2007
  6. pmc Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis
    Hanspeter Rottensteiner
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Mol Biol Cell 14:4316-28. 2003
  7. pmc Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
    W Girzalsky
    Freie Universitat Berlin, Institut fur Biochemie, 12203 Berlin, Germany
    J Cell Biol 144:1151-62. 1999
  8. doi Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis
    Silke Oeljeklaus
    Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany
    J Proteome Res 11:2567-80. 2012
  9. doi Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes
    Adabella van der Zand
    Cellular Protein Chemistry, Faculty of Science, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Cell 149:397-409. 2012
  10. pmc Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis
    Robert Rucktäschel
    Department for Systems Biochemistry, Institute for Physiological Chemistry, University of Bochum, Universitatsstrasse 150, 44780 Bochum
    J Biol Chem 284:20885-96. 2009

Scientific Experts

  • Adabella van der Zand
  • Richard A Rachubinski
  • Ralf Erdmann
  • John D Aitchison
  • Franco J Vizeacoumar
  • Hanspeter Rottensteiner
  • Xiaoling Li
  • Silke Oeljeklaus
  • Anja Huber
  • Adabella van der Zand
  • Cecile Brocard
  • Robert J Tower
  • Marcello Marelli
  • Yuen Yi C Tam
  • Barbara Knoblach
  • Robert Rucktäschel
  • Andrei Fagarasanu
  • Travis Orth
  • Wanda N Vreden
  • Harald W Platta
  • Jennifer J Smith
  • Katharina Stein
  • Jörg H Eckert
  • Stephen J Gould
  • Helmut E Meyer
  • Jürgen Gent
  • Ineke Braakman
  • Johannes Koch
  • P A Marshall
  • Andreas Hartig
  • Benedikt S Reinartz
  • Janina Wolf
  • Bettina Warscheid
  • Katharina Podwojski
  • Sebastian Wiese
  • Jason Tonillo
  • Friedrich Kragler
  • Christian Stephan
  • Henk F Tabak
  • Wolfgang Schliebs
  • Katja Kuhlmann
  • C W van Roermund
  • Andre Halbach
  • Markos Pechlivanis
  • Sven Thoms
  • Jurgen Kuhlmann
  • R Erdmann
  • Kirill Alexandrov
  • Rudolf Volkmer
  • Vadim Sidorovitch
  • W Girzalsky
  • Xinchun Zhang
  • Sigrun Reumann
  • Jianping Hu
  • Dirk Wenzel
  • Sheng Quan
  • Jilian Fan
  • Gary A Eitzen
  • Monica Fagarasanu
  • Silke Grunau
  • Katja Rosenkranz
  • Wolfgang Girzalsky
  • Rudolf Volkmer-Engert
  • Ramsey A Saleem
  • Eugene Yi
  • Stephan Lorenzen
  • Alexey I Nesvizhskii
  • Achim Kramer
  • Ruedi Aebersold
  • David R Goodlett
  • Christiane Landgraf
  • Sunhee Jung
  • Rowan H Christmas
  • Juan C Torres-Guzman
  • Eike Sonnenhol
  • Nils Johnsson
  • James C Morrell
  • Gerardo Jimenez-Sanchez
  • Eveline Baumgart
  • Kirby D Smith
  • David Valle
  • Gao Xiang Dong
  • J M Goodman
  • J M Dyer
  • M Van den Berg
  • E H Hettema
  • H F Tabak
  • R J Wanders
  • P Rehling
  • J Kipper

Detail Information

Publications22

  1. pmc Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p
    R Erdmann
    Laboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York 10021
    J Cell Biol 128:509-23. 1995
    ..The most abundant of these, Pmp27p, was purified and the corresponding gene PMP27 was cloned and sequenced...
  2. pmc Pmp27 promotes peroxisomal proliferation
    P A Marshall
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
    J Cell Biol 129:345-55. 1995
    ..We have identified a protein, Pmp27, that promotes peroxisomal proliferation. This protein, previously termed Pmp24, was purified from peroxisomal membranes, and the corresponding gene, PMP27, was isolated and sequenced...
  3. pmc Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division
    P A Marshall
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235 9041, USA
    J Cell Biol 135:123-37. 1996
    Pex11p (formerly Pmp27) has been implicated in peroxisomal proliferation (Erdmann, R., and G. Blobel. 1995. J. Cell Biol. 128; 509-523; Marshall, P.A., Y.I. Krimkevich, R.H. Lark, J.M. Dyer, M. Veenhuis, and J.M. Goodman, 1995. J...
  4. pmc Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae
    Yuen Yi C Tam
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Mol Biol Cell 14:4089-102. 2003
    ..are greatly enlarged in cells harboring double deletions of the YOR193w and PEX25 genes, the YOR193w and PEX11 genes, and the PEX25 and PEX11 genes...
  5. pmc The PEROXIN11 protein family controls peroxisome proliferation in Arabidopsis
    Travis Orth
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 19:333-50. 2007
    PEROXIN11 (PEX11) is a peroxisomal membrane protein in fungi and mammals and was proposed to play a major role in peroxisome proliferation...
  6. pmc Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis
    Hanspeter Rottensteiner
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Mol Biol Cell 14:4316-28. 2003
    ..on fatty acids of a pex25delta mutant was not exacerbated by the additional deletion of PEX27; however, when PEX11 was deleted on top of that, growth was abolished on all fatty acids...
  7. pmc Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes
    W Girzalsky
    Freie Universitat Berlin, Institut fur Biochemie, 12203 Berlin, Germany
    J Cell Biol 144:1151-62. 1999
    ..We also found Pex13p to be required for peroxisomal association of Pex14p, yet the SH3 domain of Pex13p may not provide the only binding site for Pex14p at the peroxisomal membrane...
  8. doi Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis
    Silke Oeljeklaus
    Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany
    J Proteome Res 11:2567-80. 2012
    ....
  9. doi Biochemically distinct vesicles from the endoplasmic reticulum fuse to form peroxisomes
    Adabella van der Zand
    Cellular Protein Chemistry, Faculty of Science, Utrecht University, NL 3584 CH Utrecht, The Netherlands
    Cell 149:397-409. 2012
    ..Our findings demonstrate a remarkable mechanism to maintain biochemical identity of organelles by transporting crucial components via different routes to their final destination...
  10. pmc Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis
    Robert Rucktäschel
    Department for Systems Biochemistry, Institute for Physiological Chemistry, University of Bochum, Universitatsstrasse 150, 44780 Bochum
    J Biol Chem 284:20885-96. 2009
    ..Thus, isoprenylation of Pex19p contributes to substrate membrane protein recognition for the topogenesis of PMPs, and our results highlight the importance of lipid modifications in protein-protein interactions...
  11. pmc Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals
    Hanspeter Rottensteiner
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Mol Biol Cell 15:3406-17. 2004
    ..By adding the heterologous binding site of Pex11p, peroxisomal targeting of the Pex13p fragment was restored. We conclude that Pex19p-binding sites are well-defined entities that represent an essential part of the mPTS...
  12. pmc Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae
    C W van Roermund
    Department of Clinical Chemistry, Emma Children s Hospital, University of Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    J Cell Biol 150:489-98. 2000
    ..protein Pex11p has previously been implicated in peroxisome proliferation based on morphological observations of PEX11 mutant cells...
  13. pmc A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes
    Anja Huber
    University of Vienna, Max F Perutz Laboratories, Center for Molecular Biology, Department of Biochemistry and Cell Biology, Dr Bohr Gasse 9, Vienna, Austria
    Traffic 13:157-67. 2012
    ..Among the proteins involved in the biogenesis of peroxisomes, peroxins, members of the Pex11 protein family participate in peroxisomal membrane alterations...
  14. pmc The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast
    Robert J Tower
    Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada Institute for Systems Biology, Seattle, WA 98103, USA
    Mol Biol Cell 22:1727-38. 2011
    ..proteins and a specialized divisional machinery that includes peroxisome-specific factors, such as members of the Pex11 protein family, and general organelle divisional factors, such as the dynamin-related protein Vps1p...
  15. pmc Phosphorylation-dependent activation of peroxisome proliferator protein PEX11 controls peroxisome abundance
    Barbara Knoblach
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 285:6670-80. 2010
    ..the production of Pex11p in yeast is tightly linked to peroxisome biogenesis by transcriptional regulation of the PEX11 gene, it remains unclear if and how Pex11p activity could be modulated by rapid signaling...
  16. pmc Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane
    Marcello Marelli
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Cell Biol 167:1099-112. 2004
    ..Rho1p regulates the assembly state of actin on the peroxisome membrane, thereby controlling peroxisome membrane dynamics and biogenesis...
  17. ncbi Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signals
    Franco J Vizeacoumar
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 281:14805-12. 2006
    ....
  18. ncbi The dynamin-like protein Vps1p of the yeast Saccharomyces cerevisiae associates with peroxisomes in a Pex19p-dependent manner
    Franco J Vizeacoumar
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 281:12817-23. 2006
    ..Our results are consistent with Pex19p acting as a chaperone to stabilize the association of Vps1p with peroxisomes and not as a receptor involved in targeting Vps1p to peroxisomes...
  19. ncbi Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol
    Harald W Platta
    Institut fur Physiologische Chemie, Abt Systembiochemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Nat Cell Biol 7:817-22. 2005
    ..Here we demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol...
  20. ncbi Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome
    Jörg H Eckert
    Ruhr Universitat Bochum, Institut fur Physiologische Chemie, Medizinische Fakultat, 44780 Bochum, Germany
    J Cell Sci 116:3623-34. 2003
    ..A yeast strain harboring a deletion of PEX3 enabled us to estimate the influence of the peroxisomal membrane on the formation of a subset of the investigated protein-protein interactions...
  21. pmc PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation
    Xiaoling Li
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 22:8226-40. 2002
    The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes. As part of our effort to understand the molecular and physiological functions of PEX11 proteins, we disrupted the mouse PEX11alpha gene...
  22. pmc PEX11 promotes peroxisome division independently of peroxisome metabolism
    Xiaoling Li
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 156:643-51. 2002
    The PEX11 peroxisomal membrane proteins are the only factors known to promote peroxisome division in multiple species...