Gene Symbol: PET54
Description: Pet54p
Alias: Pet54p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Brown N, Costanzo M, Fox T. Interactions among three proteins that specifically activate translation of the mitochondrial COX3 mRNA in Saccharomyces cerevisiae. Mol Cell Biol. 1994;14:1045-53 pubmed
    The PET54, PET122, and PET494 proteins, which are associated with the yeast inner mitochondrial membrane, specifically activate translation of the mitochondrially encoded COX3 mRNA...
  2. Costanzo M, Seaver E, Fox T. At least two nuclear gene products are specifically required for translation of a single yeast mitochondrial mRNA. EMBO J. 1986;5:3637-41 pubmed
    ..We show here that this specific translational activation involves at least one other newly identified gene termed PET54. Mutations in PET54 cause an absence of the coxIII protein despite the presence of normal levels of its mRNA...
  3. Wiesenberger G, Costanzo M, Fox T. Analysis of the Saccharomyces cerevisiae mitochondrial COX3 mRNA 5' untranslated leader: translational activation and mRNA processing. Mol Cell Biol. 1995;15:3291-300 pubmed
    ..5' untranslated leader (5'-UTL) required for translational activation by the protein products of the nuclear genes PET54, PET122, and PET494 in vivo...
  4. Johnson C, McEwen J. Mitochondrial protein synthesis is not required for efficient excision of intron aI5 beta from COX1 pre-mRNA in Saccharomyces cerevisiae. Mol Gen Genet. 1997;256:88-91 pubmed
    ..beta from the yeast mitochondrial COX1 transcript requires at least four proteins, encoded by the nuclear genes PET54, MRS1/PET157, SUV3 and MSS18...
  5. Naithani S, Saracco S, Butler C, Fox T. Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:324-33 pubmed
    ..mRNAs is activated mRNA specifically by the nuclearly coded proteins Pet309p, Pet111p, and the concerted action of Pet54p, Pet122p, and Pet494p, respectively...
  6. Turk E, Caprara M. Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP). J Biol Chem. 2010;285:8585-94 pubmed publisher
    ..We present a model whereby defects in Suv3p result in accumulation of stable, excised group I intron ribonucleoproteins, which result in sequestration of Mrs1p, and a concomitant reduction in splicing of aI5beta. ..
  7. Mayorga J, Camacho Villasana Y, Shingú Vázquez M, García Villegas R, Zamudio Ochoa A, García Guerrero A, et al. A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria. J Biol Chem. 2016;291:9343-55 pubmed publisher
    ..In yeast, Pet54 protein is required to activate translation of the COX3 mRNA and to process the aI5β intron on the COX1 ..
  8. Costanzo M, Seaver E, Fox T. The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics. 1989;122:297-305 pubmed
    The product of the nuclear Saccharomyces cerevisiae gene PET54 is specifically required, along with at least two other nuclear gene products, for translation of the mitochondrial mRNA encoding subunit III of cytochrome c oxidase (coxIII)...
  9. McMullin T, Fox T. COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae. J Biol Chem. 1993;268:11737-41 pubmed
    Three yeast proteins coded by nuclear genes, PET54, PET122, and PET494, are specifically required to activate translation of the mitochondrially coded COX3 mRNA, and one of them, PET122, has been shown to interact functionally with both ..

More Information


  1. Kaspar B, Bifano A, Caprara M. A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria. Nucleic Acids Res. 2008;36:2958-68 pubmed publisher
    The Pet54p protein is an archetypical example of a dual functioning ('moonlighting') protein: it is required for translational activation of the COX3 mRNA and splicing of the aI5beta group I intron in the COX1 pre-mRNA in Saccharomyces ..