Gene Symbol: PET191
Species: Saccharomyces cerevisiae S288c
Khalimonchuk O, Rigby K, Bestwick M, Pierrel F, Cobine P, Winge D. Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae. Eukaryot Cell. 2008;7:1427-31 pubmed publisher
The twin-Cx(9)C motif protein Pet191 is essential for cytochrome c oxidase maturation...
Vögtle F, Burkhart J, Rao S, Gerbeth C, Hinrichs J, Martinou J, et al
. Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics. 2012;11:1840-52 pubmed publisher
..We present here the first and comprehensive proteome of IMS proteins of yeast mitochondria with 51 proteins in total. The IMS proteome will serve as a valuable source for further studies on the role of the IMS in cell life and death. ..
Bragoszewski P, Gornicka A, Sztolsztener M, Chacinska A. The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins. Mol Cell Biol. 2013;33:2136-48 pubmed publisher
..Thus, the ubiquitin-proteasome system plays an important role in determining the levels of proteins targeted to the intermembrane space of mitochondria. ..
McEwen J, Hong K, Park S, Preciado G. Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiae. Curr Genet. 1993;23:9-14 pubmed
The nuclear genes PET117 and PET191 are required for the assembly of active cytochrome c oxidase in S. cerevisiae, yet their gene products are not subunits of the final assembled cytochrome c oxidase complex...
Gornicka A, Bragoszewski P, Chrościcki P, Wenz L, Schulz C, Rehling P, et al
. A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria. Mol Biol Cell. 2014;25:3999-4009 pubmed publisher
..Thus MIA-dependent proteins take another route across the outer mitochondrial membrane that involves Tom40 in a form that is different from the canonical TOM complex. ..
Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener M, Oeljeklaus S, et al
. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature. 2015;524:485-8 pubmed publisher
..UPRam provides a means for buffering the consequences of physiological slowdown in mitochondrial protein import and for counteracting pathologies that are caused or contributed by mitochondrial dysfunction. ..