Gene Symbol: PET127
Species: Saccharomyces cerevisiae S288c
Wiesenberger G, Fox T. Pet127p, a membrane-associated protein involved in stability and processing of Saccharomyces cerevisiae mitochondrial RNAs. Mol Cell Biol. 1997;17:2816-24 pubmed
..blocked respiratory growth and caused cells to lose wild-type mitochondrial DNA, suggesting that too much Pet127p prevents mitochondrial gene expression...
Chen W, Islas Osuna M, Dieckmann C. Suppressor analysis of mutations in the 5'-untranslated region of COB mRNA identifies components of general pathways for mitochondrial mRNA processing and decay in Saccharomyces cerevisiae. Genetics. 1999;151:1315-25 pubmed
..One group of four mutations is in PET127, which is required for 5' end processing of several mitochondrial mRNAs...
Wegierski T, Dmochowska A, Jabłonowska A, Dziembowski A, Bartnik E, Stepien P. Yeast nuclear PET127 gene can suppress deletions of the SUV3 or DSS1 genes: an indication of a functional interaction between 3' and 5' ends of mitochondrial mRNAs. Acta Biochim Pol. 1998;45:935-40 pubmed
..We have found that the yeast nuclear gene PET127 present on a low or high copy number vector can effectively suppress the effects of the SUV3 or DSS1 gene ..
Fekete Z, Ellis T, Schonauer M, Dieckmann C. Pet127 governs a 5' -> 3'-exonuclease important in maturation of apocytochrome b mRNA in Saccharomyces cerevisiae. J Biol Chem. 2008;283:3767-72 pubmed
..Accumulation of precursor COB RNA in single and double element strains with a deletion of PET127 demonstrated that the encoded protein governs the 5'-exonuclease responsible for processing the precursor to the ..
Haffter P, Fox T. Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational activator PET122 by mutations in two new genes, MRP17 and PET127. Mol Gen Genet. 1992;235:64-73 pubmed
..The second new suppressor gene described here, PET127, encodes a protein too large (M(r) 95900) to be a ribosomal protein and appears to operate by a different ..
Turk E, Caprara M. Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP). J Biol Chem. 2010;285:8585-94 pubmed publisher
..We present a model whereby defects in Suv3p result in accumulation of stable, excised group I intron ribonucleoproteins, which result in sequestration of Mrs1p, and a concomitant reduction in splicing of aI5beta. ..
Markov D, Savkina M, Anikin M, Del Campo M, Ecker K, Lambowitz A, et al
. Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Yeast. 2009;26:423-40 pubmed publisher
..Among the proteins found in the pull-down were a DEAD-box protein (Mss116p) and an RNA-binding protein (Pet127p)...