Gene Symbol: PET122
Description: Pet122p
Alias: Pet122p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Brown N, Costanzo M, Fox T. Interactions among three proteins that specifically activate translation of the mitochondrial COX3 mRNA in Saccharomyces cerevisiae. Mol Cell Biol. 1994;14:1045-53 pubmed
    The PET54, PET122, and PET494 proteins, which are associated with the yeast inner mitochondrial membrane, specifically activate translation of the mitochondrially encoded COX3 mRNA...
  2. Folley L, Fox T. Site-directed mutagenesis of a Saccharomyces cerevisiae mitochondrial translation initiation codon. Genetics. 1991;129:659-68 pubmed
    ..of the cox3-1 mutant mRNA was dependent upon the three nuclearly coded mRNA-specific activators PET494, PET54 and PET122, known from previous studies to work through a site (or sites) upstream of the initiation codon to promote ..
  3. Mayorga J, Camacho Villasana Y, Shingú Vázquez M, García Villegas R, Zamudio Ochoa A, García Guerrero A, et al. A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria. J Biol Chem. 2016;291:9343-55 pubmed publisher
    ..Pet54 may play a role in Mss51 hemylation/conformational change necessary for translational activity. Moreover, Pet54 physically interacts with the COX1 mRNA, and this binding was independent of the presence of Mss51. ..
  4. Thompson D, Stahl F. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics. 1999;153:621-41 pubmed
    ..phenotype in diploid SPO13 meiosis in our strain background, and they identify alleles of UBR1, INP52, BUD3, PET122, ELA1, and MSC1-MSC3...
  5. Naithani S, Saracco S, Butler C, Fox T. Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:324-33 pubmed
    ..activated mRNA specifically by the nuclearly coded proteins Pet309p, Pet111p, and the concerted action of Pet54p, Pet122p, and Pet494p, respectively...
  6. Haffter P, Fox T. Suppression of carboxy-terminal truncations of the yeast mitochondrial mRNA-specific translational activator PET122 by mutations in two new genes, MRP17 and PET127. Mol Gen Genet. 1992;235:64-73 pubmed
    The PET122 protein is one of three Saccharomyces cerevisiae nuclear gene products required specifically to activate translation of the mitochondrially coded COX3 mRNA...
  7. Costanzo M, Fox T. Specific translational activation by nuclear gene products occurs in the 5' untranslated leader of a yeast mitochondrial mRNA. Proc Natl Acad Sci U S A. 1988;85:2677-81 pubmed
    ..subunit III (coxIII) is specifically activated by the products of at least three nuclear genes, PET494, PET54, and PET122. To investigate whether the target site for translational activation is within the 5' untranslated leader of the ..
  8. Green Willms N, Fox T, Costanzo M. Functional interactions between yeast mitochondrial ribosomes and mRNA 5' untranslated leaders. Mol Cell Biol. 1998;18:1826-34 pubmed
    ..We propose that mitochondrial ribosomes themselves recognize a common feature of mRNA 5'-UTLs which, in conjunction with mRNA-specific translational activation, is required for organellar translation initiation. ..
  9. McMullin T, Fox T. COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae. J Biol Chem. 1993;268:11737-41 pubmed
    Three yeast proteins coded by nuclear genes, PET54, PET122, and PET494, are specifically required to activate translation of the mitochondrially coded COX3 mRNA, and one of them, PET122, has been shown to interact functionally with both ..

More Information


  1. McMullin T, Haffter P, Fox T. A novel small-subunit ribosomal protein of yeast mitochondria that interacts functionally with an mRNA-specific translational activator. Mol Cell Biol. 1990;10:4590-5 pubmed
    ..Some mutations affecting one of these activators, PET122, can be suppressed by mutations in an unlinked nuclear gene termed PET123...
  2. Costanzo M, Fox T. Suppression of a defect in the 5' untranslated leader of mitochondrial COX3 mRNA by a mutation affecting an mRNA-specific translational activator protein. Mol Cell Biol. 1993;13:4806-13 pubmed
    ..encoding subunit III of cytochrome c oxidase, specifically requires the action of the nuclear gene products PET54, PET122, and PET494 at a site encoded in the 612-base 5' untranslated leader...
  3. Davie J, Kane C. Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex. Mol Cell Biol. 2000;20:5960-73 pubmed
    ..The detection of these genetic interactions provides another functional link between the Swi-Snf complex and the elongation machinery. ..
  4. Haffter P, McMullin T, Fox T. A genetic link between an mRNA-specific translational activator and the translation system in yeast mitochondria. Genetics. 1990;125:495-503 pubmed
    ..cytochrome c oxidase subunit III (coxIII) specifically requires the products of at least three nuclear genes, PET122, PET494 and PET54...
  5. Haffter P, McMullin T, Fox T. Functional interactions among two yeast mitochondrial ribosomal proteins and an mRNA-specific translational activator. Genetics. 1991;127:319-26 pubmed
    ..c oxidase subunit III is specifically activated at the level of translation by at least three nuclear genes, PET122, PET494 and PET54...