Genomes and Genes
Gene Symbol: PEP1
Description: type I sorting receptor
Alias: VPS10, VPT1, type I sorting receptor
Species: Saccharomyces cerevisiae S288c
- Westphal V, Marcusson E, Winther J, Emr S, van den Hazel H. Multiple pathways for vacuolar sorting of yeast proteinase A. J Biol Chem. 1996;271:11865-70 pubmed..This was unexpected, as strains disrupted for VPS10 sort more than 85% of the proteinase A to the vacuole...
- Nothwehr S, Ha S, Bruinsma P. Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p. J Cell Biol. 2000;151:297-310 pubmed..These data strongly support a model in which Vps35p acts as a "receptor" protein for recognition of the retrieval signal domains of cargo proteins during their recruitment into retrograde vesicles. ..
- Möckli N, Deplazes A, Hassa P, Zhang Z, Peter M, Hottiger M, et al. Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins. Biotechniques. 2007;42:725-30 pubmed..The cytoY2H system extends existing methods for the detection of protein interactions by providing a convenient solution for screening a wide range of transcriptionally active proteins. ..
- Deloche O, Schekman R. Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants. Mol Biol Cell. 2002;13:4296-307 pubmed..Once relieved of cargo protein, Vps10p would be recycled to the trans-Golgi and then to the cell surface for further rounds of sorting. ..