Gene Symbol: PDR11
Description: ATP-binding cassette multidrug transporter PDR11
Alias: ATP-binding cassette multidrug transporter PDR11
Species: Saccharomyces cerevisiae S288c
Rogers B, Decottignies A, Kolaczkowski M, Carvajal E, Balzi E, Goffeau A. The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol. 2001;3:207-14 pubmed
..Multiple deletion of 7 ABC genes (YOR1, SNQ2, PDR5, YCF1, PDR10, PDR11 and PDR15) and of two transcription activation factors (PDR1 and PDR3) renders the cell from 2 to 200 times more ..
Marek M, Milles S, Schreiber G, Daleke D, Dittmar G, Herrmann A, et al
. The yeast plasma membrane ATP binding cassette (ABC) transporter Aus1: purification, characterization, and the effect of lipids on its activity. J Biol Chem. 2011;286:21835-43 pubmed publisher
..These results suggest a direct interaction between Aus1 and PS that is critical for the activity of the transporter...
Laub K, Marek M, Stanchev L, Herrera S, Kanashova T, Bourmaud A, et al
. Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p. PLoS ONE. 2017;12:e0184236 pubmed publisher
..Our results highlight distinct differences between Pdr11p and Aus1p and create an experimental basis for further biochemical studies of both ABC transporters to elucidate their function. ..
Wilcox L, Balderes D, Wharton B, Tinkelenberg A, Rao G, Sturley S. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem. 2002;277:32466-72 pubmed
..Deletion of the ATP-binding cassette transporters YOR011w (AUS1) or PDR11, or a putative cell wall protein encoded by DAN1, significantly reduced sterol influx...
Kohut P, Wüstner D, Hronska L, Kuchler K, Hapala I, Valachovic M. The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study. Biochem Biophys Res Commun. 2011;404:233-8 pubmed publisher
..amounts of exogenous ergosterol and DHE (but not cholesterol) associated with uptake-deficient hem1?aus1?pdr11? cells...
Gulati S, Balderes D, Kim C, Guo Z, Wilcox L, Area Gomez E, et al
. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. FASEB J. 2015;29:4682-94 pubmed publisher